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3.6.1.62: 5'-(N7-methylguanosine 5'-triphospho)-[mRNA] hydrolase

This is an abbreviated version!
For detailed information about 5'-(N7-methylguanosine 5'-triphospho)-[mRNA] hydrolase, go to the full flat file.

Word Map on EC 3.6.1.62

Reaction

a 5'-(N7-methylguanosine 5'-triphospho)-[mRNA]
+
H2O
=
N7-methylguanosine 5'-diphosphate
+
a 5'-phospho-[mRNA]

Synonyms

D10 decapping enzyme, D10 protein, D9 protein, Dcp1p, Dcp2, Dcp2p, decapping nudix hydrolase, EC 3.6.1.30, H29K, hDcp2, hNUDT16, mRNA decapping enzyme, mRNA decapping enzyme D10, mRNA decapping enzyme D9, Nudt16, Nudt17, Nudt19, Nudt20, NUDT3, U8 snoRNA binding protein, X29, X29 protein

ECTree

     3 Hydrolases
         3.6 Acting on acid anhydrides
             3.6.1 In phosphorus-containing anhydrides
                3.6.1.62 5'-(N7-methylguanosine 5'-triphospho)-[mRNA] hydrolase

Disease

Disease on EC 3.6.1.62 - 5'-(N7-methylguanosine 5'-triphospho)-[mRNA] hydrolase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
5'-(n7-methylguanosine 5'-triphospho)-[mrna] hydrolase deficiency
CAG RNAs induce DNA damage and apoptosis by silencing NUDT16 expression in polyglutamine degeneration.
Infections
Virus-induced translational arrest through 4EBP1/2-dependent decay of 5'-TOP mRNAs restricts viral infection.
Mental Retardation, X-Linked
Identification of an mRNA-decapping regulator implicated in X-linked mental retardation.
Muscular Atrophy, Spinal
A library approach to rapidly discover photoaffinity probes of the mRNA decapping scavenger enzyme DcpS.
Poxviridae Infections
The D10 decapping enzyme of vaccinia virus contributes to decay of cellular and viral mRNAs and to virulence in mice.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Epigenetic loss of the RNA decapping enzyme NUDT16 mediates C-MYC activation in T-cell acute lymphoblastic leukemia.
Thyroid Neoplasms
Comprehensive Analysis of the Functions and Prognostic Value of RNA-Binding Proteins in Thyroid Cancer.
Vaccinia
Characterization of a vaccinia virus mutant with a deletion of the D10R gene encoding a putative negative regulator of gene expression.
Characterization of the vaccinia virus D10 decapping enzyme provides evidence for a two-metal-ion mechanism.
Down regulation of gene expression by the vaccinia virus D10 protein.
Insights into the molecular determinants involved in cap recognition by the vaccinia virus D10 decapping enzyme.
Investigation of IRES Insertion into the Genome of Recombinant MVA as a Translation Enhancer in the Context of Transcript Decapping.
The D10 decapping enzyme of vaccinia virus contributes to decay of cellular and viral mRNAs and to virulence in mice.
Vaccinia virus D10 protein has mRNA decapping activity, providing a mechanism for control of host and viral gene expression.
Virus Diseases
Characterization of a vaccinia virus mutant with a deletion of the D10R gene encoding a putative negative regulator of gene expression.