3.6.1.62: 5'-(N7-methylguanosine 5'-triphospho)-[mRNA] hydrolase
This is an abbreviated version!
For detailed information about 5'-(N7-methylguanosine 5'-triphospho)-[mRNA] hydrolase, go to the full flat file.
Reaction
Synonyms
D10 decapping enzyme, D10 protein, D9 protein, Dcp1p, Dcp2, Dcp2p, decapping nudix hydrolase, EC 3.6.1.30, H29K, hDcp2, hNUDT16, mRNA decapping enzyme, mRNA decapping enzyme D10, mRNA decapping enzyme D9, Nudt16, Nudt17, Nudt19, Nudt20, NUDT3, U8 snoRNA binding protein, X29, X29 protein
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Natural Substrates Products
Natural Substrates Products on EC 3.6.1.62 - 5'-(N7-methylguanosine 5'-triphospho)-[mRNA] hydrolase
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REACTION DIAGRAM
a 5'-(N7-methylguanosine 5'-triphospho)-[mRNA] + H2O
N7-methylguanosine 5'-diphosphate + a 5'-phospho-[mRNA]
N7-methylguanosine 5'-diphosphate + a 5'-phospho-[mRNA]
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a 5'-(N7-methylguanosine 5'-triphospho)-[mRNA] + H2O
N7-methylguanosine 5'-diphosphate + a 5'-phospho-[mRNA]
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a 5'-(N7-methylguanosine 5'-triphospho)-[mRNA] + H2O
N7-methylguanosine 5'-diphosphate + a 5'-phospho-[mRNA]
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m7GDP + 5'-phospho-mRNA
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DCP2 and the interacting proteins DCP1, and VCS form a decapping complex in vivo. mRNA turnover mediated by the decapping complex is required for postembryonic development in Arabidopsis
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m7G5'ppp5'-mRNA + H2O
m7GDP + 5'-phospho-mRNA
Dcp2 is involved in mRNA decay
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m7G5'ppp5'-mRNA + H2O
m7GDP + 5'-phospho-mRNA
decapping of mRNA is a critical step in eukaryotic mRNA turnover
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m7G5'ppp5'-mRNA + H2O
m7GDP + 5'-phospho-mRNA
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hNUDT16 relies on divalent cations for its cap-hydrolysis activity to remove m7GDP and m227GDP from RNAs
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m7G5'ppp5'-mRNA + H2O
m7GDP + 5'-phospho-mRNA
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mRNA decapping is a critical step in the control of mRNA stability and gene expression
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m7G5'ppp5'-mRNA + H2O
m7GDP + 5'-phospho-mRNA
regulation of RNA degradation plays an important role in the control of gene expression. Mammalian cells possess multiple mRNA decapping enzymes to regulate mRNA turnover. Nudt16, like Dcp2, is involved in mRNA stability. Each decapping enzyme can selectively affect the stability of at least a subset of mRNAs
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m7G5'ppp5'-mRNA + H2O
m7GDP + 5'-phospho-mRNA
regulation of RNA degradation plays an important role in the control of gene expression. Mammalian cells possess multiple mRNA decapping enzymes to regulate mRNA turnover. Nudt16, like Dcp2, is involved in mRNA stability. Each decapping enzyme can selectively affect the stability of at least a subset of mRNAs
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m7G5'ppp5'-mRNA + H2O
m7GDP + 5'-phospho-mRNA
Dcp2 has role in mRNA decay
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m7G5'ppp5'-mRNA + H2O
m7GDP + 5'-phospho-mRNA
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D9 is expressed early in infection and D10 late. It is suggested that the two proteins enhance mRNA turnover and manipulate gene expression in a complementary and overlapping manner
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m7G5'ppp5'-mRNA + H2O
m7GDP + 5'-phospho-mRNA
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the mRNA decapping activity of D10 allows vaccinia virus to accelerate degradation of viral and host messages. By degrading host mRNAs, VACV D10 may have an immunomodulatory role
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m7GDP + 5'-phospho-U8 snoRNA
removes m7G and m227G caps from RNAs, rendering them substrates for 5'-3' exonucleases for degradation in vivo
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m7G5'ppp5'-U8 snoRNA + H2O
m7GDP + 5'-phospho-U8 snoRNA
removes m7G and m227G caps from RNAs, rendering them substrates for 5'-3' exonucleases for degradation in vivo
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