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Literature summary for 3.6.1.62 extracted from

  • Li, Y.; Dai, J.; Song, M.; Fitzgerald-Bocarsly, P.; Kiledjian, M.
    Dcp2 decapping protein modulates mRNA stability of the critical interferon regulatory factor (IRF) IRF-7 (2012), Mol. Cell. Biol., 32, 1164-1172.
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Mus musculus Q9CYC6
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-

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast embryonic fibroblast Mus musculus
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Synonyms

Synonyms Comment Organism
Dcp2
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus Dcp2 expression is induced upon viral infection up

General Information

General Information Comment Organism
physiological function embryonic fibroblast cells with reduced Dcp2 levels contain significantly elevated levels of mRNAs encoding proteins involved in the type I IFN response. Both IRF-7 mRNA and protein are increased in cells with reduced Dcp2 levels. The increase in IRF-7 mRNA within the background of reduced Dcp2 levels is attributed to a stabilization of the IRF-7 mRNA, suggesting that Dcp2 normally modulates IRF-7 mRNA stability Mus musculus