3.6.1.45: UDP-sugar diphosphatase
This is an abbreviated version!
For detailed information about UDP-sugar diphosphatase, go to the full flat file.
Word Map on EC 3.6.1.45
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3.6.1.45
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cholera
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clostridium
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difficile
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retrograde
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mucosal
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diarrhea
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iga
-
rho
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gm1
-
tracer
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tcda
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ganglioside
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stool
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toxigenic
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colitis
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innervation
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afferent
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gtpases
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anterograde
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intranasal
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tracing
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difficile-associated
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nosocomial
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cdc42
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cytotoxin
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botulinum
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pseudomembranous
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antibiotic-associated
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rostral
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enterotoxin
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sordellii
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cytolethal
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toxoid
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intermediolateral
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clostridioides
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parabrachial
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parvicellular
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leucoagglutinin
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antibody-secreting
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ventrolateral
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enterotoxigenic
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transganglionic
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antitoxin
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ribotype
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pentameric
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tract-tracing
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fluoro-gold
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holotoxin
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non-toxigenic
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preganglionic
- 3.6.1.45
- cholera
- clostridium
- difficile
-
retrograde
- mucosal
-
diarrhea
- iga
- rho
- gm1
-
tracer
- tcda
- ganglioside
-
stool
-
toxigenic
- colitis
-
innervation
-
afferent
- gtpases
-
anterograde
-
intranasal
-
tracing
-
difficile-associated
-
nosocomial
- cdc42
-
cytotoxin
- botulinum
-
pseudomembranous
-
antibiotic-associated
-
rostral
- enterotoxin
- sordellii
-
cytolethal
- toxoid
-
intermediolateral
- clostridioides
-
parabrachial
-
parvicellular
-
leucoagglutinin
-
antibody-secreting
-
ventrolateral
-
enterotoxigenic
-
transganglionic
- antitoxin
-
ribotype
-
pentameric
-
tract-tracing
-
fluoro-gold
-
holotoxin
-
non-toxigenic
-
preganglionic
Reaction
Synonyms
5'-nucleotidase/UDP-sugar hydrolase, hydrolase, uridine diphosphoglucose (Escherichia coli precursor reduced), hydrolase, uridine diphosphoglucose (Escherichia coli reduced), hydrolase, uridine diphosphoglucose (Salmonella typhimurium clone pAGS5 gene ushB isoenzyme reduced), hydrolase, uridine diphosphoglucose (Salmonella typhimurium gene ushA0 isoenzyme precursor reduced), hydrolase, uridine diphosphoglucose (Salmonella typhimurium gene ushA0 isoenzyme reduced), nucleosidediphosphate-sugar diphosphatase, nucleosidediphosphate-sugar pyrophosphatase, Nudix hydrolase-like nucleotide hydrolase, toxin A, toxin B, UDP-glucose pyrophosphatase, UDP-sugar diphosphatase, UDP-sugar hydrolase, UDP-sugar pyrophosphatase, UDPG pyrophosphatase, UGPPase, UshA, UshB protein
ECTree
3.6.1.45 UDP-sugar diphosphataseAdvanced search results
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results (Engineering
Engineering on EC 3.6.1.45 - UDP-sugar diphosphatase
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PROTEIN VARIANTS 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
F463L
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enhanced 5' nucleotidase activity, UDP-sugar hydrolase activity not determined
S139Y
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occurs naturally, loss of 5' nucleotidase activity, UDP-sugar hydrolase activity not determined
S139Y/F463Y
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loss of 5' nucleotidase activity, UDP-sugar hydrolase activity not determined
additional information
additional information
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carboxyterminal deletion which abolishes the 5' nucleotidase activity and deletion of the signal peptide
additional information
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deletion of the signal peptide, identical to the mature periplasmic enzyme, except for the presence of an N-terminal methionine residue, expressed in Escherichia coli 5A-1
additional information
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ushA knockouts are unable to grow on AMP as the only carbon source and are significantly delayed or impaired in their growth on other purine nucleotides. Growth on nonadenine purine nucleotides is made possible by an acid phosphatase encoded by the aphA gene, which at neutral pH acts as an efficient 5'-nucleotidase of purine nucleotides, except AMP. Double knockouts in ushA and aphA do not grow on nucleotides AMP
