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3.6.1.45: UDP-sugar diphosphatase

This is an abbreviated version!
For detailed information about UDP-sugar diphosphatase, go to the full flat file.

Word Map on EC 3.6.1.45

Reaction

UDP-sugar
+
H2O
=
UMP
 +
alpha-D-aldose 1-phosphate

Synonyms

5'-nucleotidase/UDP-sugar hydrolase, hydrolase, uridine diphosphoglucose (Escherichia coli precursor reduced), hydrolase, uridine diphosphoglucose (Escherichia coli reduced), hydrolase, uridine diphosphoglucose (Salmonella typhimurium clone pAGS5 gene ushB isoenzyme reduced), hydrolase, uridine diphosphoglucose (Salmonella typhimurium gene ushA0 isoenzyme precursor reduced), hydrolase, uridine diphosphoglucose (Salmonella typhimurium gene ushA0 isoenzyme reduced), nucleosidediphosphate-sugar diphosphatase, nucleosidediphosphate-sugar pyrophosphatase, Nudix hydrolase-like nucleotide hydrolase, toxin A, toxin B, UDP-glucose pyrophosphatase, UDP-sugar diphosphatase, UDP-sugar hydrolase, UDP-sugar pyrophosphatase, UDPG pyrophosphatase, UGPPase, UshA, UshB protein

ECTree

     3 Hydrolases
         3.6 Acting on acid anhydrides
             3.6.1 In phosphorus-containing anhydrides
                3.6.1.45 UDP-sugar diphosphatase

Reference

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Reference on EC 3.6.1.45 - UDP-sugar diphosphatase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Garrett, A.R.; Johnson, L.A.; Beacham, I.R.
Isolation, molecular characterization and expression of the ushB gene of Salmonella typhimurium which encodes a membrane-bound UDP-sugar hydrolase
Mol. Microbiol.
3
177-186
1989
Escherichia coli, Salmonella enterica subsp. enterica serovar Typhimurium
Manually annotated by BRENDA team
Burns, D.M.; Beacham, I.R.
Nucleotide sequence and transcriptional analysis of the E. coli ushA gene, encoding periplasmic UDP-sugar hydrolase (5'-nucleotidase): regulation of the ushA gene, and the signal sequence of its encoded protein product
Nucleic Acids Res.
14
4325-4342
1986
Escherichia coli
Manually annotated by BRENDA team
Burns, D.M.; Abraham, L.J.; Beacham, I.R.
Characterization of the ush gene of Escherichia coli and its protein products
Gene
25
343-353
1983
Escherichia coli
Manually annotated by BRENDA team
Cowman, A.; Beacham, I.R.
Molecular cloning of the gene (ush) from Escherichia coli specifying periplasmic UDP-sugar hydrolase (5'-nucleotidase)
Gene
12
281-286
1980
Escherichia coli
Manually annotated by BRENDA team
Beacham, I.R.; Wilson, M.S.
Studies on the UDP-sugar hydrolases from Escherichia coli and Salmonella typhimurium
Arch. Biochem. Biophys.
218
603-608
1982
Escherichia coli, Salmonella enterica subsp. enterica serovar Typhimurium
Manually annotated by BRENDA team
Taylor, N.; Beacham, I.R.
Synthesis of Escherichia coli uridine diphosphate glucose hydrolase, and demonstration of an inhibitor, in Salmonella typhimurium cytoplasm
Biochem. Soc. Trans.
3
386-387
1975
Escherichia coli, Salmonella enterica subsp. enterica serovar Typhimurium
Manually annotated by BRENDA team
Taylor, N.S.; Beacham, I.R.
Synthesis and localization of Escherichia coli UDP-glucose hydrolase (5'-nucleotidase), and demonstration of a cytoplasmic inhibitor of this enzyme in Salmonella typhimurium
Biochim. Biophys. Acta
411
216-221
1975
Escherichia coli, Salmonella enterica subsp. enterica serovar Typhimurium
Manually annotated by BRENDA team
Jones, R.A.; Burns, D.M.; Carruthers, D.J.; Beacham, I.R.
Membrane localization of a UDP-sugar hydrolase, in Salmonella, is by an uncleaved N-terminal signal peptide
FEMS Microbiol. Lett.
114
299-304
1993
Salmonella sp.
Manually annotated by BRENDA team
Ciesla, W.P.; Bobak, D.A.
Clostridium difficile toxins A and B are cation-dependent UDP-glucose hydrolases with differing catalytic activities
J. Biol. Chem.
273
16021-16026
1998
Clostridioides difficile
Manually annotated by BRENDA team
Edwards, C.J.; Innes, D.J.; Burns, D.M.; Beacham, I.R.
UDP-sugar hydrolase isozymes in Salmonella enterica and Escherichia coli: silent alleles of ushA in related strains of group I Salmonella isolates, and of ushB in wild-type and K12 strains of E. coli, indicate recent and early silencing events, respectively
FEMS Microbiol. Lett.
114
293-298
1993
Escherichia coli, Salmonella enterica subsp. enterica serovar Typhimurium
Manually annotated by BRENDA team
Glaser, L.; Melo, A.; Paul, R.
Uridine diphosphate sugar hydrolase. Purification of enzyme and protein inhibitor
J. Biol. Chem.
242
1944-1954
1967
Escherichia coli
Manually annotated by BRENDA team
Decottignies, A.; Kolaczkowski, M.; Balzi, E.; Goffeau, A.
Solubilization and characterization of the overexpressed PDR5 multidrug resistance nucleotide triphosphatase of yeast
J. Biol. Chem.
269
12797-12803
1994
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Innes, D.; Beacham, I.R.; Burns, D.M.
The role of the intracellular inhibitor of periplasmic UDP-sugar hydrolase (5'-nucleotidase) in Escherichia coli: cytoplasmic localisation of 5'-nucleotidase is conditionally lethal
J. Basic Microbiol.
41
329-337
2001
Escherichia coli
Manually annotated by BRENDA team
Lee, K.S.; Song, S.B.; Kim, K.E.; Kim, Y.H.; Kim, S.K.; Kho, B.H.; Ko, D.K.; Choi, Y.K.; Lee, Y.K.; Kim, C.K.; Kim, Y.C.; Lim, J.Y.; Kim, Y.; Min, K.H.; Wanner, B.L.
Cloning and characterization of the UDP-sugar hydrolase gene (ushA) of Enterobacter aerogenes IFO 12010
Biochem. Biophys. Res. Commun.
269
526-531
2000
Klebsiella aerogenes (Q9RQT7), Klebsiella aerogenes, Klebsiella aerogenes IFO 12010 (Q9RQT7)
Manually annotated by BRENDA team
Rittmann, D.; Sorger-Herrmann, U.; Wendisch, V.F.
Phosphate starvation-inducible gene ushA encodes a 5 nucleotidase required for growth of Corynebacterium glutamicum on media with nucleotides as the phosphorus source
Appl. Environ. Microbiol.
71
4339-4344
2005
Corynebacterium glutamicum
Manually annotated by BRENDA team
Innes, D.; Beacham, I.R.; Beven, C.A.; Douglas, M.; Laird, M.W.; Joly, J.C.; Burns, D.M.
The cryptic ushA gene (ushA(c)) in natural isolates of Salmonella enterica (serotype Typhimurium) has been inactivated by a single missense mutation
Microbiology
147
1887-1896
2001
Salmonella enterica
Manually annotated by BRENDA team
Yagi, T.; Baroja-Fernandez, E.; Yamamoto, R.; Munnoz, F.-J.; Akazawa, A.; Hong, K.S.; Pozueta-Romero, J.
Cloning, expression and characterization of a mammalian Nudix hydrolase-like enzyme that cleaves the pyrophosphate bond of UDP-glucose
Biochem. J.
370
409-415
2003
Sus scrofa, Homo sapiens (O95848), Homo sapiens
Manually annotated by BRENDA team
Alves-Pereira, I.; Canales, J.; Cabezas, A.; Cordero, P.M.; Costas, M.J.; Cameselle, J.C.
CDP-alcohol hydrolase, a very efficient activity of the 5-nucleotidase/UDP-sugar hydrolase encoded by the ushA gene of Yersinia intermedia and Escherichia coli
J. Bacteriol.
190
6153-6161
2008
Escherichia coli, Yersinia intermedia (A4URQ8), Yersinia intermedia, Yersinia intermedia CECT 7230 (A4URQ8)
Manually annotated by BRENDA team
Heyen, C.A.; Tagliabracci, V.S.; Zhai, L.; Roach, P.J.
Characterization of mouse UDP-glucose pyrophosphatase, a Nudix hydrolase encoded by the Nudt14 gene
Biochem. Biophys. Res. Commun.
390
1414-1418
2009
Mus musculus (Q9D142), Mus musculus
Manually annotated by BRENDA team
Wang, L.; Zhou, Y.J.; Ji, D.; Lin, X.; Liu, Y.; Zhang, Y.; Liu, W.; Zhao, Z.K.
Identification of UshA as a major enzyme for NAD degradation in Escherichia coli
Enzyme Microb. Technol.
58-59
75-79
2014
Escherichia coli (B1XCS0), Escherichia coli DH10B (B1XCS0)
Manually annotated by BRENDA team