3.5.1.48: acetylspermidine deacetylase

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For detailed information about acetylspermidine deacetylase, go to the full flat file.

Reaction

Synonyms

acetylpolyamine amidohydrolase, APAH, HDAC10, histone deacetylase 10, N1-acetylspermidine amidohydrolase, N1-acetylspermidine deacetylase, N8-acetyl-monoacetylspermidine deacetylase, N8-acetylspermidine deacetylase, polyamine deacetylase, zHDAC10

ECTree

     3 Hydrolases

         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds

             3.5.1 In linear amides

                3.5.1.48 acetylspermidine deacetylase

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Results	in table
2	Activating Compound
102	AA Sequence
2	Application
1	CAS Registry Number
3	Cloned(Commentary)
1	Crystallization (Commentary)
220	Disease/ Diagnostics
8	General Information
86	Inhibitors
35	kcat/KM [mM/s]
23	Ki Value [mM]
44	KM Value [mM]
8	Localization
5	Metals/Ions
6	Natural Substrates/ Products (Substrates)
15	Organism
26	PDB ID
6	pH Optimum
1	pH Stability
6	Protein Variants
4	Purification (Commentary)
1	Reaction
1	Reaction Type
15	Reference
24	Source Tissue
2	Specific Activity [micromol/min/mg]
1	Storage Stability
54	Substrates and Products (Substrate)
1	Subunits
21	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
2	Temperature Stability [°C]
37	Turnover Number [1/s]

Crystallization

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Crystallization on EC 3.5.1.48 - acetylspermidine deacetylase

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CRYSTALLIZATION (Commentary)

ORGANISM

UNIPROT

LITERATURE

purified enzyme zHDAC10 mutant Y307F complexed with a polyamine transition state analogue inhibitor AAT, sitting drop vapour diffusion method, mixing of 400 nl of 30 mg/ml Y307F zHDAC10DELTA-AAT complex and 5 mM AAT with 400 nl of precipitant solution containing 0.2 M KH2PO4, and 20% PEG 3350, and equilibration against 0.08 ml precipitant solution, 24 h, 4°C, X-ray diffraction structure determination and analysis at 2.85 A resolution, molecular replacement using structure of the zHDAC6 CD1-TSA complex (PDB ID 5EEF)

Danio rerio

F1QCV2

754843