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3.5.1.48: acetylspermidine deacetylase

This is an abbreviated version!
For detailed information about acetylspermidine deacetylase, go to the full flat file.

Word Map on EC 3.5.1.48

Reaction

N8-Acetylspermidine
+
H2O
=
acetate
 +
spermidine

Synonyms

acetylpolyamine amidohydrolase, APAH, HDAC10, histone deacetylase 10, N1-acetylspermidine amidohydrolase, N1-acetylspermidine deacetylase, N8-acetyl-monoacetylspermidine deacetylase, N8-acetylspermidine deacetylase, polyamine deacetylase, zHDAC10

ECTree

     3 Hydrolases
         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
             3.5.1 In linear amides
                3.5.1.48 acetylspermidine deacetylase

Inhibitors

Inhibitors on EC 3.5.1.48 - acetylspermidine deacetylase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1,10-phenanthroline
-
Ki: 1.3 mM
1,4-diaminobutane
1,5-Diaminopentane
-
cadaverine; Ki: 1.5 mM
1,6-diaminohexane
-
Ki: 1.5 mM
2,2'-dipyridyl
-
Ki: 1.9 mM
2-mercaptoethanol
-
slight inhibition at 1 mM
3-[(3-aminopropyl)amino]-N-hydroxyhexanamide
-
non-competitive inhibition, Ki: 1 nM
5-Aminovaleric acid
-
Ki: 4.1 mM
5-[(3-aminopropyl)amino]pentane-1-thiol
-
-
5-[(3-aminopropyl)amino]pentylboronic acid
-
-
6-aminohexanoic acid
-
Ki: 0.05 mM
6-[(3-aminopropyl)amino]-N-hydroxyhexanamide
-
-
6-[(3-aminopropyl)amino]hexanoic acid
7-[(3-aminopropyl)amino]-1,1,1-trifluoroheptan-2-one
7-[(3-aminopropyl)amino]-1-methoxyheptan-2-one
-
-
7-[(3-aminopropyl)amino]heptan-2-one
-
-
7-[N-(3-aminopropyl)amino]heptan-2-one
8-hydroxyquinoline
-
slight inhibition at 1 mM
acetylprocainamide
-
Ki: 1.9 mM
Acriflavin
-
strong inhibition at 1 mM
Cu2+
-
nearly complete inhibition at 1 mM
Diethylmalonate
-
Ki: 8 mM
diisopropyl fluorophosphate
-
weak inhibition, Ki: 33 mM
dithiothreitol
echothiopate
-
non-competitive inhibition, Ki: 0.4 mM, i.e.ammonium, (2-mercaptoethyl)trimethyl-, S-ester with O,O-diethyl phosphorothioate
Fe2+
-
strong inhibition at 1 mM
iodoacetamide
-
slight inhibition at 1 mM
N',N''-bis(tert-butoxycarbonyl)-6-[(3-aminopropyl)amino]-N-hydroxyhexanamide
-
-
N',N''-bis(tert-butoxycarbonyl)-6-[(3-aminopropyl)amino]-N-methoxy-N-methylhexanamide
-
-
N,N'-bis(tert-butoxycarbonyl)-5-[(3-aminopropyl)amino]pentan-1-ol
-
-
N,N'-bis(tert-butoxycarbonyl)-5-[(3-aminopropyl)amino]pentane-1-thiol
-
-
N,N'-bis(tert-butoxycarbonyl)-6-[(3-aminopropyl)amino]hexanal
-
-
N,N'-bis(tert-butoxycarbonyl)-6-[(3-aminopropyl)amino]hexanoic acid
-
-
N,N'-bis(tert-butoxycarbonyl)-7-[(3-aminopropyl)amino]-1,1,1-trifluoroheptan-2-ol
-
-
N,N'-bis(tert-butoxycarbonyl)-7-[(3-aminopropyl)amino]-1,1,1-trifluoroheptan-2-one
-
-
N,N'-bis(tert-butoxycarbonyl)-7-[(3-aminopropyl)amino]-1-bromoheptan-2-ol
-
-
N,N'-bis(tert-butoxycarbonyl)-7-[(3-aminopropyl)amino]-1-bromoheptan-2-one
-
-
N,N'-bis(tert-butoxycarbonyl)-7-[(3-aminopropyl)amino]-1-methoxyheptan-2-ol
-
-
N,N'-bis(tert-butoxycarbonyl)-7-[(3-aminopropyl)amino]-1-methoxyheptan-2-one
-
-
N,N'-bis(tert-butoxycarbonyl)-7-[(3-aminopropyl)amino]heptan-2-one
-
-
N-acetylputrescine
-
Ki: 0.8 mM
N-ethylmaleimide
-
Ki: 0.86 mM
N1,N3-bis(tert-butoxycarbonyl)-N1-(5-bromopentyl)propane-1,3-diamine
-
-
N1,N3-bis(tert-butoxycarbonyl)-N1-(hept-6-enyl)propane-1,3-diamine
-
-
N1,N3-bis(tert-butoxycarbonyl)-N1-(pent-4-enyl)propane-1,3-diamine
-
-
N1,N3-bis(tert-butoxycarbonyl)-N1-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pentyl]propane-1,3-diamine
-
-
N1,N3-bis(tert-butoxycarbonyl)-N1-[5-(methylsulfonyl)pentyl]propane-1,3-diamine
-
-
N1,N3-bis(tert-butoxycarbonyl)-N1-[5-(methylthio)pentyl]propane-1,3-diamine
-
-
N1,N3-bis(tert-butoxycarbonyl)-N1-[5-(oxiran-2-yl)pentyl]propane-1,3-diamine
-
-
N1-(hept-6-enyl)propane-1,3-diamine
-
-
N1-(pent-4-enyl)propane-1,3-diamine
-
-
N1-acetylspermidine
N1-[5-(methylsulfonyl)pentyl]propane-1,3-diamine
-
-
N8-Acetylspermidine
-
stimulation of cell growth due to inhibition of N8-acetylspremidine deacetylase, maximum cell growth stimulation above 1 mM
NaN3
-
slight inhibition at 1 mM
p-chloromercuribenzoic acid
Pargyline
-
slight inhibition at 1 mM
Quinacrine
-
strong inhibition at 1 mM
S-{5-[(3-aminopropyl)amino]pentyl} thioacetate
-
-
S-{7-[(3-aminopropyl)amino]-2-oxoheptyl} ethanethioate
-
-
S-{N,N'-bis(tert-butoxycarbonyl)-5-[(3-aminopropyl)amino]pentyl} thioacetate
-
-
S-{N,N'-bis(tert-butoxycarbonyl)-7-[(3-aminopropyl)amino]-2-oxoheptyl}thioacetate
-
-
Semicarbazide
-
slight inhibition at 1 mM
sodium butyrate
-
weak inhibition, Ki: 38.5 mM
spermidine
spermine
additional information
-
design, synthesis, and evaluation of N8-acetylspermidine analogues bearing different zinc binding groups as potential inhibitors of the enzyme, overview. Most of the synthesized compounds exhibit modest potency, with IC50 values in the mid-micromolar range, but compounds bearing hydroxamate or trifluoromethylketone zinc binding groups exhibit enhanced inhibitory potency in the mid-nanomolar range. Three compounds exhibit very poor inhibitory potency against th enzyme, 6-[(3-aminopropyl)amino]hexanoic acid, S-{5-[(3-aminopropyl)amino]pentyl} thioacetate, and N1-[5-(methylsulfonyl)pentyl]propane-1,3-diamine dihydrochloride
-