3.5.1.48: acetylspermidine deacetylase

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For detailed information about acetylspermidine deacetylase, go to the full flat file.

Word Map on EC 3.5.1.48

3.5.1.48

deacetylases

deacetylation

hdac11

mycoplana

ramosa

pharmacology

drug development

Reaction

Synonyms

acetylpolyamine amidohydrolase, APAH, HDAC10, histone deacetylase 10, N1-acetylspermidine amidohydrolase, N1-acetylspermidine deacetylase, N8-acetyl-monoacetylspermidine deacetylase, N8-acetylspermidine deacetylase, polyamine deacetylase, zHDAC10

ECTree

3 Hydrolases

3.5 Acting on carbon-nitrogen bonds, other than peptide bonds

3.5.1 In linear amides

3.5.1.48 acetylspermidine deacetylase

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Results	in table
2	Activating Compound
102	AA Sequence
2	Application
1	CAS Registry Number
3	Cloned(Commentary)
1	Crystallization (Commentary)
220	Disease/ Diagnostics
8	General Information
86	Inhibitors
35	kcat/KM [mM/s]
23	Ki Value [mM]
44	KM Value [mM]
8	Localization
5	Metals/Ions
6	Natural Substrates/ Products (Substrates)
15	Organism
26	PDB ID
6	pH Optimum
1	pH Stability
6	Protein Variants
4	Purification (Commentary)
1	Reaction
1	Reaction Type
15	Reference
24	Source Tissue
2	Specific Activity [micromol/min/mg]
1	Storage Stability
54	Substrates and Products (Substrate)
1	Subunits
21	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
2	Temperature Stability [°C]
37	Turnover Number [1/s]

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Natural Substrates Products on EC 3.5.1.48 - acetylspermidine deacetylase

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N1-acetylspermidine + H2O

acetate + spermidine

Mycoplana ramosa

733494

N8-acetylspermidine + H2O

acetate + spermidine

4 entries

additional information

Mycoplana ramosa

the bacterial enzyme from Mycoplana ramosa has broader substrate specificity in comparison with mammalian enzyme. Its substrates include both small and large acetylpolyamines such as acetylputrescine, acetylcadaverine, N1- and N8-acetylspermidine, and N1-acetylspermine

733494