3.5.1.48: acetylspermidine deacetylase
This is an abbreviated version!
For detailed information about acetylspermidine deacetylase, go to the full flat file.
Word Map on EC 3.5.1.48
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3.5.1.48
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deacetylases
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deacetylation
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hdac11
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mycoplana
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ramosa
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pharmacology
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drug development
- 3.5.1.48
- deacetylases
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deacetylation
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hdac11
- mycoplana
- ramosa
- pharmacology
- drug development
Reaction
Synonyms
acetylpolyamine amidohydrolase, APAH, HDAC10, histone deacetylase 10, N1-acetylspermidine amidohydrolase, N1-acetylspermidine deacetylase, N8-acetyl-monoacetylspermidine deacetylase, N8-acetylspermidine deacetylase, polyamine deacetylase, zHDAC10
ECTree
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Engineering
Engineering on EC 3.5.1.48 - acetylspermidine deacetylase
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E274L
site-directed mutagenesis, steady-state kinetics, mutation of the glutamate gatekeeper residue
Y307F
site-directed mutagenesis, introduction of the deactivating Y307F mutation facilitates crystallization
additional information
construction of deletion mutant DELTAnuA2, steady-state kinetics. The universal 310 helix nuA2 insertion in loop L1 further constricts the HDAC10 active site. Generation of mutant zHDAC10DELTA by treatement with trypsin
additional information
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construction of deletion mutant DELTAnuA2, steady-state kinetics. The universal 310 helix nuA2 insertion in loop L1 further constricts the HDAC10 active site. Generation of mutant zHDAC10DELTA by treatement with trypsin