3.5.1.48: acetylspermidine deacetylase

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For detailed information about acetylspermidine deacetylase, go to the full flat file.

Word Map on EC 3.5.1.48

3.5.1.48

deacetylases

deacetylation

hdac11

mycoplana

ramosa

pharmacology

drug development

Reaction

N8-Acetylspermidine

+

H2O

=

acetate

+

spermidine

Synonyms

acetylpolyamine amidohydrolase, APAH, HDAC10, histone deacetylase 10, N1-acetylspermidine amidohydrolase, N1-acetylspermidine deacetylase, N8-acetyl-monoacetylspermidine deacetylase, N8-acetylspermidine deacetylase, polyamine deacetylase, zHDAC10

ECTree

3.5 Acting on carbon-nitrogen bonds, other than peptide bonds

3.5.1 In linear amides

3.5.1.48 acetylspermidine deacetylase

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Results	in table
2	Activating Compound
102	AA Sequence
2	Application
1	CAS Registry Number
3	Cloned(Commentary)
1	Crystallization (Commentary)
220	Disease/ Diagnostics
8	General Information
86	Inhibitors
35	kcat/KM [mM/s]
23	Ki Value [mM]
44	KM Value [mM]
8	Localization
5	Metals/Ions
6	Natural Substrates/ Products (Substrates)
15	Organism
26	PDB ID
6	pH Optimum
1	pH Stability
6	Protein Variants
4	Purification (Commentary)
1	Reaction
1	Reaction Type
15	Reference
24	Source Tissue
2	Specific Activity [micromol/min/mg]
1	Storage Stability
54	Substrates and Products (Substrate)
1	Subunits
21	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
2	Temperature Stability [°C]
37	Turnover Number [1/s]

KI Value

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KI Value on EC 3.5.1.48 - acetylspermidine deacetylase

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1.3

1,10-phenanthroline

-

-

1.45

1,4-diaminobutane

-

-

1.5

1,5-Diaminopentane

-

-

1.5

1,6-diaminohexane

-

-

1.9

2,2'-dipyridyl

-

-

0.000001

3-[(3-aminopropyl)amino]-N-hydroxyhexanamide

-

non-competitive inhibition

4.1

5-Aminovaleric acid

-

-

0.05

6-aminohexanoic acid

-

-

0.011

6-[(3-aminopropyl)amino]hexanoic acid

-

-

0.0007

7-[(3-aminopropyl)amino]-1,1,1-trifluoroheptan-2-one

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1.9

acetylprocainamide

-

-

8

Diethylmalonate

-

-

33

diisopropyl fluorophosphate

-

weak inhibition

0.4

echothiopate

-

non-competitive inhibition, i.e.ammonium, (2-mercaptoethyl)trimethyl-, S-ester with O,O-diethyl phosphorothioate

3.5 - 5

EDTA

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0.8

N-acetylputrescine

-

-

1.37

N1-acetylspermidine

-

-

0.15

p-chloromercuribenzoic acid

-

-

38.5

sodium butyrate

-

weak inhibition

0.31

spermidine

-

-

1.15

spermine

-

-

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Release 2023.1 (January 2023)