3.5.1.108: UDP-3-O-acyl-N-acetylglucosamine deacetylase

This is an abbreviated version!
For detailed information about UDP-3-O-acyl-N-acetylglucosamine deacetylase, go to the full flat file.

Reaction

Synonyms

deacetylase, deacetylase LpxC, DHTase, EnvA protein, LpxC, LpxC deacetylase, LpxC enzyme, LpxC protein, UDP-(3-O-(R-3-hydroxymyristoyl))-N-acetylglucosamine deacetylase, UDP-(3-O-acyl)-N-acetylglucosamine deacetylase, UDP-3-O-((R)-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase, UDP-3-O-(acyl)-N-acetylglucosamine deacetylase, UDP-3-O-(R-3-hydroxyacyl)-N-acetylglucosamine deacetylase, UDP-3-O-(R-3-hydroxymyristoyl)-GlcNAc deacetylase, UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase, UDP-3-O-(R-3-hydroxymyristoyl)-Nacetylglucosamine deacetylase, UDP-3-O-acyl-GlcNAc deacetylase, UDP-3-O-acyl-N-acetylglucosamine deacetylase, UDP-3-O-[(3R)-3-hydroxymyristoyl]-N-acetylglucosamine amidohydrolase, UDP-3-O-[(R)-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase, UDP-3-O-[R-3-hydroxymyristoyl]-GlcNAc deacetylase, UDP-3-O-[R-3-hydroxymyristoyl]-GlcNAc deacetylase enzyme, uridine diphosphate-(3-O-(R-3-hydroxymyristoyl))-N-acetylglucosamine deacetylase, zinc deacetylase LpxC

ECTree

     3 Hydrolases

         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds

             3.5.1 In linear amides

                3.5.1.108 UDP-3-O-acyl-N-acetylglucosamine deacetylase

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Results	in table
1	Activating Compound
23088	AA Sequence
19	Application
1	CAS Registry Number
16	Cloned(Commentary)
11	Crystallization (Commentary)
20	General Information
2	General Stability
501	IC50 Value
808	Inhibitors
24	kcat/KM [mM/s]
57	Ki Value [mM]
21	KM Value [mM]
1	Localization
37	Metals/Ions
5	Molecular Weight [Da]
36	Natural Substrates/ Products (Substrates)
96	Organism
11	Pathway
65	PDB ID
18	pH Optimum
2	pH Range
77	Protein Variants
25	Purification (Commentary)
1	Reaction
71	Reference
4	Specific Activity [micromol/min/mg]
86	Substrates and Products (Substrate)
4	Subunits
123	Synonyms
1	Systematic Name
16	Temperature Optimum [°C]
2	Temperature Stability [°C]
22	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 3.5.1.108 - UDP-3-O-acyl-N-acetylglucosamine deacetylase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

UDP-3-O-((R)-3-hydroxymyristoyl)-N-acetylglucosamine + H2O

UDP-3-O-((R)-3-hydroxymyristoyl)-D-glucosamine + acetate

20 entries

UDP-3-O-[(3R)-3-hydroxymyristoyl]-N-acetyl-alpha-D-glucosamine + H2O

UDP-3-O-[(3R)-3-hydroxymyristoyl]-alpha-D-glucosamine + acetate

7 entries

additional information

?

-

5 entries

UDP-3-O-((R)-3-hydroxymyristoyl)-N-acetylglucosamine + H2O

UDP-3-O-((R)-3-hydroxymyristoyl)-D-glucosamine + acetate

Aquifex aeolicus

-

LpxC catalyzes a step in the biosynthesis of lipid A in Gram-negative bacteria

696198

-

-

?

UDP-3-O-((R)-3-hydroxymyristoyl)-N-acetylglucosamine + H2O

UDP-3-O-((R)-3-hydroxymyristoyl)-D-glucosamine + acetate

Aquifex aeolicus

-

LpxC catalyzes the first committed step in the biosynthesis of lipid A, the hydrophobic anchor of lipopolysaccharide (LPS) that constitutes the outermost monolayer of Gram-negative bacteria. As LpxC is crucial for the survival of Gram-negative organisms and has no sequence homology to known mammalian deacetylases or amidases

700371

-

-

?

UDP-3-O-((R)-3-hydroxymyristoyl)-N-acetylglucosamine + H2O

UDP-3-O-((R)-3-hydroxymyristoyl)-D-glucosamine + acetate

Aquifex aeolicus

O67648

LpxC catalyzes the first committed step in the biosynthesis of lipid A, the hydrophobic anchor of lipopolysaccharide (LPS) that constitutes the outermost monolayer of Gram-negative bacteria. As LpxC is crucial for the survival of Gram-negative organisms and has no sequence homology to known mammalian deacetylases or amidases

696204

-

-

?

UDP-3-O-((R)-3-hydroxymyristoyl)-N-acetylglucosamine + H2O

UDP-3-O-((R)-3-hydroxymyristoyl)-D-glucosamine + acetate

Aquifex aeolicus

-

LpxC is a key enzyme in the biochemical synthesis of Lipid A

699767

-

-

?

UDP-3-O-((R)-3-hydroxymyristoyl)-N-acetylglucosamine + H2O

UDP-3-O-((R)-3-hydroxymyristoyl)-D-glucosamine + acetate

Escherichia coli

-

-

695629, 696193

-

-

?

UDP-3-O-((R)-3-hydroxymyristoyl)-N-acetylglucosamine + H2O

UDP-3-O-((R)-3-hydroxymyristoyl)-D-glucosamine + acetate

Escherichia coli

-

natural substrate

695628

-

-

?

UDP-3-O-((R)-3-hydroxymyristoyl)-N-acetylglucosamine + H2O

UDP-3-O-((R)-3-hydroxymyristoyl)-D-glucosamine + acetate

Escherichia coli

-

biosynthesis of lipid A in Gram negarive bacteria

696180

-

-

?

UDP-3-O-((R)-3-hydroxymyristoyl)-N-acetylglucosamine + H2O

UDP-3-O-((R)-3-hydroxymyristoyl)-D-glucosamine + acetate

Escherichia coli

-

committed step in the biosynthesis of lipid A

696209

-

-

?

UDP-3-O-((R)-3-hydroxymyristoyl)-N-acetylglucosamine + H2O

UDP-3-O-((R)-3-hydroxymyristoyl)-D-glucosamine + acetate

Escherichia coli

-

committed step of lipopolysaccharide biosynthesis

698550

-

-

?

UDP-3-O-((R)-3-hydroxymyristoyl)-N-acetylglucosamine + H2O

UDP-3-O-((R)-3-hydroxymyristoyl)-D-glucosamine + acetate

Escherichia coli

-

first committed step of lipid A biosynthesis, regulation of enzyme activity, overview

486257

-

-

?

UDP-3-O-((R)-3-hydroxymyristoyl)-N-acetylglucosamine + H2O

UDP-3-O-((R)-3-hydroxymyristoyl)-D-glucosamine + acetate

Escherichia coli

-

LpxC catalyzes a step in the biosynthesis of lipid A in Gram-negative bacteria

696198

-

-

?

UDP-3-O-((R)-3-hydroxymyristoyl)-N-acetylglucosamine + H2O

UDP-3-O-((R)-3-hydroxymyristoyl)-D-glucosamine + acetate

Escherichia coli

-

LpxC is one of the key enzymes of bacterial lipid A biosynthesis, catalyzing the removal of the N-acetyl group of UD-3-O-((R)-3-hydroxymyristoyl)-N-acetylglucosamine. The lpxC gene is essential in Gram-negative bacteria but absent from mammalian genomes, making it an attractive target for antibacterial drug discovery

695538

-

-

?

UDP-3-O-((R)-3-hydroxymyristoyl)-N-acetylglucosamine + H2O

UDP-3-O-((R)-3-hydroxymyristoyl)-D-glucosamine + acetate

Escherichia coli

-

second enzymatic step of lipid A biosynthesis

698700

-

-

?

UDP-3-O-((R)-3-hydroxymyristoyl)-N-acetylglucosamine + H2O

UDP-3-O-((R)-3-hydroxymyristoyl)-D-glucosamine + acetate

Escherichia coli

-

the enzyme is involved in lipid A biosynthesis

681983

-

-

?

UDP-3-O-((R)-3-hydroxymyristoyl)-N-acetylglucosamine + H2O

UDP-3-O-((R)-3-hydroxymyristoyl)-D-glucosamine + acetate

Escherichia coli

-

this reaction is essential in the biosynthesis of lipopolysaccharide (LPS) of Gram-negative bacteria and is an attractive target for the development of new antibacterial agents

699038

-

-

?

UDP-3-O-((R)-3-hydroxymyristoyl)-N-acetylglucosamine + H2O

UDP-3-O-((R)-3-hydroxymyristoyl)-D-glucosamine + acetate

Escherichia coli D22

-

natural substrate

695628

-

-

?

UDP-3-O-((R)-3-hydroxymyristoyl)-N-acetylglucosamine + H2O

UDP-3-O-((R)-3-hydroxymyristoyl)-D-glucosamine + acetate

Escherichia coli SM105

-

first committed step of lipid A biosynthesis, regulation of enzyme activity, overview

486257

-

-

?

UDP-3-O-((R)-3-hydroxymyristoyl)-N-acetylglucosamine + H2O

UDP-3-O-((R)-3-hydroxymyristoyl)-D-glucosamine + acetate

Escherichia coli W3110 / ATCC 27325

-

the enzyme is involved in lipid A biosynthesis

681983

-

-

?

UDP-3-O-((R)-3-hydroxymyristoyl)-N-acetylglucosamine + H2O

UDP-3-O-((R)-3-hydroxymyristoyl)-D-glucosamine + acetate

Pseudomonas aeruginosa

P47205

a committed step of lipopolysaccharide biosynthesis

698550

-

-

?

UDP-3-O-((R)-3-hydroxymyristoyl)-N-acetylglucosamine + H2O

UDP-3-O-((R)-3-hydroxymyristoyl)-D-glucosamine + acetate

Pseudomonas aeruginosa

-

by placing the lpxC gene of Pseudomonas aeruginosa under tight control of an arabinose-inducible promoter, the essentiality of LpxC activity for Pseudomonas aeruginosa is demonstrated

695629

-

-

?

UDP-3-O-[(3R)-3-hydroxymyristoyl]-N-acetyl-alpha-D-glucosamine + H2O

UDP-3-O-[(3R)-3-hydroxymyristoyl]-alpha-D-glucosamine + acetate

Aquifex aeolicus

O67648

-

732992

-

-

r

UDP-3-O-[(3R)-3-hydroxymyristoyl]-N-acetyl-alpha-D-glucosamine + H2O

UDP-3-O-[(3R)-3-hydroxymyristoyl]-alpha-D-glucosamine + acetate

Aquifex aeolicus

O67648

the enzyme catalyzes the first committed step in the biosynthesis of lipid A, an essential component of the outer membrane of Gram-negative bacteria

755346

-

-

?

UDP-3-O-[(3R)-3-hydroxymyristoyl]-N-acetyl-alpha-D-glucosamine + H2O

UDP-3-O-[(3R)-3-hydroxymyristoyl]-alpha-D-glucosamine + acetate

Escherichia coli

-

-

735297, 735298, 735299

-

-

?

UDP-3-O-[(3R)-3-hydroxymyristoyl]-N-acetyl-alpha-D-glucosamine + H2O

UDP-3-O-[(3R)-3-hydroxymyristoyl]-alpha-D-glucosamine + acetate

Escherichia coli

-

-

732992, 734239

-

-

r

UDP-3-O-[(3R)-3-hydroxymyristoyl]-N-acetyl-alpha-D-glucosamine + H2O

UDP-3-O-[(3R)-3-hydroxymyristoyl]-alpha-D-glucosamine + acetate

Escherichia coli W3110 / ATCC 27325

-

-

732992

-

-

r

UDP-3-O-[(3R)-3-hydroxymyristoyl]-N-acetyl-alpha-D-glucosamine + H2O

UDP-3-O-[(3R)-3-hydroxymyristoyl]-alpha-D-glucosamine + acetate

Pseudomonas aeruginosa

-

-

732992

-

-

r

UDP-3-O-[(3R)-3-hydroxymyristoyl]-N-acetyl-alpha-D-glucosamine + H2O

UDP-3-O-[(3R)-3-hydroxymyristoyl]-alpha-D-glucosamine + acetate

Pseudomonas aeruginosa

-

first committed step in the biosynthesis of lipid A

754390

-

-

?

additional information

?

-

Escherichia coli

-

catalyses the second step of lipid A biosynthesis in Gram-negative bacteria

698451

-

-

?

additional information

?

-

Escherichia coli

-

catalyzes the second step in the biosynthesis of lipid A

695628

-

-

?

additional information

?

-

Escherichia coli

-

catalyzes the second step in the biosynthesis of lipid A

696210

-

-

?

additional information

?

-

Escherichia coli

-

catalyzes the second step of lipid A biosynthesis in Gram negative bacteria

699421

-

-

?

additional information

?

-

Escherichia coli D22

-

catalyzes the second step in the biosynthesis of lipid A

695628

-

-

?