Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.5.1.108 extracted from

  • Mdluli, K.E.; Witte, P.R.; Kline, T.; Barb, A.W.; Erwin, A.L.; Mansfield, B.E.; McClerren, A.L.; Pirrung, M.C.; Tumey, L.N.; Warrener, P.; Raetz, C.R.; Stover, C.K.
    Molecular validation of LpxC as an antibacterial drug target in Pseudomonas aeruginosa (2006), Antimicrob. Agents Chemother., 50, 2178-2184.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.5.1.108

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Pseudomonas aeruginosa
expression in Pseudomonas aeruginosa Escherichia coli

Inhibitors

Inhibitors Comment Organism Structure
(4R)-2-(3,4-dimethoxy-5-propylphenyl)-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide the inhibitor is active against a Pseudomonas aeruginosa construct in which the endogenous lpxC gene is inactivated and in which LpxC activity is supplied by the lpxC gene from Escherichia coli. An Escherichia coli construct in which growth is dependent on the Pseudomonas aeruginosa lpxC gene is resistant to the compound Escherichia coli
additional information (4R)-2-(3,4-dimethoxy-5-propylphenyl)-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide is active against a Pseudomonas aeruginosa construct in which the endogenous lpxC gene is inactivated and in which LpxC activity is supplied by the lpxC gene from Escherichia coli. An Escherichia coli construct in which growth is dependent on the Pseudomonas aeruginosa lpxC gene is resistant to the compound Pseudomonas aeruginosa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-3-O-((R)-3-hydroxymyristoyl)-N-acetylglucosamine + H2O Escherichia coli
-
 UDP-3-O-((R)-3-hydroxymyristoyl)-D-glucosamine + acetate
-
 ?
UDP-3-O-((R)-3-hydroxymyristoyl)-N-acetylglucosamine + H2O Pseudomonas aeruginosa by placing the lpxC gene of Pseudomonas aeruginosa under tight control of an arabinose-inducible promoter, the essentiality of LpxC activity for Pseudomonas aeruginosa is demonstrated UDP-3-O-((R)-3-hydroxymyristoyl)-D-glucosamine + acetate
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-
Pseudomonas aeruginosa
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-3-O-((R)-3-hydroxymyristoyl)-N-acetylglucosamine + H2O
-
 Escherichia coli UDP-3-O-((R)-3-hydroxymyristoyl)-D-glucosamine + acetate
-
 ?
UDP-3-O-((R)-3-hydroxymyristoyl)-N-acetylglucosamine + H2O
-
 Pseudomonas aeruginosa UDP-3-O-((R)-3-hydroxymyristoyl)-D-glucosamine + acetate
-
 ?
UDP-3-O-((R)-3-hydroxymyristoyl)-N-acetylglucosamine + H2O by placing the lpxC gene of Pseudomonas aeruginosa under tight control of an arabinose-inducible promoter, the essentiality of LpxC activity for Pseudomonas aeruginosa is demonstrated Pseudomonas aeruginosa UDP-3-O-((R)-3-hydroxymyristoyl)-D-glucosamine + acetate
-
 ?

Synonyms

Synonyms Comment Organism
UDP-3-O-(R-3-hydroxymyristoyl)-GlcNAc deacetylase
-
 Escherichia coli
UDP-3-O-(R-3-hydroxymyristoyl)-GlcNAc deacetylase
-
 Pseudomonas aeruginosa