3.5.1.108: UDP-3-O-acyl-N-acetylglucosamine deacetylase

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For detailed information about UDP-3-O-acyl-N-acetylglucosamine deacetylase, go to the full flat file.

Word Map on EC 3.5.1.108

3.5.1.108

histone

sirt1

deacetylation

sirtuins

nad+-dependent

chromatin

hdacs

nicotinamide

acetyltransferase

resveratrol

nad+

nucleosome

trichostatin

repressor

longevity

lifespan

hyperacetylation

corepressors

calorie

coactivator

sirt1-mediated

tubulin

forkhead

non-histone

proliferator-activated

hydroxamic

panobinostat

microtubule

heterochromatin

pgc-1alpha

foxos

phenacetin

mef2

deacylase

suberoylanilide

romidepsin

aggresome

sirtinol

sirt1-dependent

synthesis

pan-hdac

cortactin

pharmacology

medicine

drug development

chromodomain

chromatin-remodeling

ubiquitin-binding

saha

nampt

vorinostat

paraoxon

dinucleotide-dependent

chromatin-modifying

Reaction

a UDP-3-O-[(3R)-3-hydroxyacyl]-N-acetyl-alpha-D-glucosamine

a UDP-3-O-[(3R)-3-hydroxyacyl]-alpha-D-glucosamine

Synonyms

deacetylase, deacetylase LpxC, DHTase, EnvA protein, LpxC, LpxC deacetylase, LpxC enzyme, LpxC protein, UDP-(3-O-(R-3-hydroxymyristoyl))-N-acetylglucosamine deacetylase, UDP-(3-O-acyl)-N-acetylglucosamine deacetylase, UDP-3-O-((R)-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase, UDP-3-O-(acyl)-N-acetylglucosamine deacetylase, UDP-3-O-(R-3-hydroxyacyl)-N-acetylglucosamine deacetylase, UDP-3-O-(R-3-hydroxymyristoyl)-GlcNAc deacetylase, UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase, UDP-3-O-(R-3-hydroxymyristoyl)-Nacetylglucosamine deacetylase, UDP-3-O-acyl-GlcNAc deacetylase, UDP-3-O-acyl-N-acetylglucosamine deacetylase, UDP-3-O-[(3R)-3-hydroxymyristoyl]-N-acetylglucosamine amidohydrolase, UDP-3-O-[(R)-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase, UDP-3-O-[R-3-hydroxymyristoyl]-GlcNAc deacetylase, UDP-3-O-[R-3-hydroxymyristoyl]-GlcNAc deacetylase enzyme, uridine diphosphate-(3-O-(R-3-hydroxymyristoyl))-N-acetylglucosamine deacetylase, zinc deacetylase LpxC

ECTree

3 Hydrolases

3.5 Acting on carbon-nitrogen bonds, other than peptide bonds

3.5.1 In linear amides

3.5.1.108 UDP-3-O-acyl-N-acetylglucosamine deacetylase

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Results	in table
1	Activating Compound
23088	AA Sequence
19	Application
1	CAS Registry Number
16	Cloned(Commentary)
11	Crystallization (Commentary)
20	General Information
2	General Stability
501	IC50 Value
808	Inhibitors
24	kcat/KM [mM/s]
57	Ki Value [mM]
21	KM Value [mM]
1	Localization
37	Metals/Ions
5	Molecular Weight [Da]
36	Natural Substrates/ Products (Substrates)
96	Organism
11	Pathway
65	PDB ID
18	pH Optimum
2	pH Range
77	Protein Variants
25	Purification (Commentary)
1	Reaction
71	Reference
4	Specific Activity [micromol/min/mg]
86	Substrates and Products (Substrate)
4	Subunits
123	Synonyms
1	Systematic Name
16	Temperature Optimum [°C]
2	Temperature Stability [°C]
22	Turnover Number [1/s]

pH Optimum

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pH Optimum on EC 3.5.1.108 - UDP-3-O-acyl-N-acetylglucosamine deacetylase

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5.5

assay at

5.9

assay at

assay at

7.4

7.5

8.5

Pseudomonas aeruginosa

P47205

698550

additional information

Escherichia coli

affinity of EcLpxC for the product (myrUDP-GlcNH2) is determined as a function of pH to ascertain whether there are ionizations important for binding affinity. For wild-type LpxC, the KD product value increases at both low and high pH in a log-linear fashion, indicating that two ionizations affect binding affinity

696210