3.5.1.108: UDP-3-O-acyl-N-acetylglucosamine deacetylase

This is an abbreviated version!
For detailed information about UDP-3-O-acyl-N-acetylglucosamine deacetylase, go to the full flat file.

Reaction

Synonyms

deacetylase, deacetylase LpxC, DHTase, EnvA protein, LpxC, LpxC deacetylase, LpxC enzyme, LpxC protein, UDP-(3-O-(R-3-hydroxymyristoyl))-N-acetylglucosamine deacetylase, UDP-(3-O-acyl)-N-acetylglucosamine deacetylase, UDP-3-O-((R)-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase, UDP-3-O-(acyl)-N-acetylglucosamine deacetylase, UDP-3-O-(R-3-hydroxyacyl)-N-acetylglucosamine deacetylase, UDP-3-O-(R-3-hydroxymyristoyl)-GlcNAc deacetylase, UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase, UDP-3-O-(R-3-hydroxymyristoyl)-Nacetylglucosamine deacetylase, UDP-3-O-acyl-GlcNAc deacetylase, UDP-3-O-acyl-N-acetylglucosamine deacetylase, UDP-3-O-[(3R)-3-hydroxymyristoyl]-N-acetylglucosamine amidohydrolase, UDP-3-O-[(R)-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase, UDP-3-O-[R-3-hydroxymyristoyl]-GlcNAc deacetylase, UDP-3-O-[R-3-hydroxymyristoyl]-GlcNAc deacetylase enzyme, uridine diphosphate-(3-O-(R-3-hydroxymyristoyl))-N-acetylglucosamine deacetylase, zinc deacetylase LpxC

ECTree

     3 Hydrolases

         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds

             3.5.1 In linear amides

                3.5.1.108 UDP-3-O-acyl-N-acetylglucosamine deacetylase

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Results	in table
1	Activating Compound
23088	AA Sequence
19	Application
1	CAS Registry Number
16	Cloned(Commentary)
11	Crystallization (Commentary)
20	General Information
2	General Stability
501	IC50 Value
808	Inhibitors
24	kcat/KM [mM/s]
57	Ki Value [mM]
21	KM Value [mM]
1	Localization
37	Metals/Ions
5	Molecular Weight [Da]
36	Natural Substrates/ Products (Substrates)
96	Organism
11	Pathway
65	PDB ID
18	pH Optimum
2	pH Range
77	Protein Variants
25	Purification (Commentary)
1	Reaction
71	Reference
4	Specific Activity [micromol/min/mg]
86	Substrates and Products (Substrate)
4	Subunits
123	Synonyms
1	Systematic Name
16	Temperature Optimum [°C]
2	Temperature Stability [°C]
22	Turnover Number [1/s]

Application

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Application on EC 3.5.1.108 - UDP-3-O-acyl-N-acetylglucosamine deacetylase

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APPLICATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

drug development

9 entries

medicine

8 entries

pharmacology

Pseudomonas aeruginosa

P47205

the enzyme is a target for antibiotic therapy and structure-based drug design

735205

synthesis

Escherichia coli

-

construction of immobilized metal affinity membrane via coupling of epichlorohydrin, iminodiacetic acid, and nickel ion on a regenerated cellulose membrane. The D-hydantoin-hydrolyzing enzyme harboring a poly-His tagged residue is immobilized on the prepared membrane. By employing a membrane with nickel ion of 155.5 micromol/disc immersed in 0.1 M Tris-HCl buffer pH 8, with 0.8 M sodium chloride, an enzyme activity of 4.2 U/disc is obtained. The immobilized DHTase membrane can achieve a larger pH and thermaltolerance range than the free enzyme. 99% of enzyme activity can be retained after 15 repeated uses

718765

drug development

Pseudomonas aeruginosa

-

enzyme is an attractive target against Pseudomonas infection

696606

drug development

Escherichia coli

-

lipid A is an essential component of the outer membranes of most Gram-negative bacteria, making LpxC an attractive target for antibiotic design

696206

drug development

Aquifex aeolicus

-

lipid A is an essential component of the outer membranes of most Gram-negative bacteria, making LpxC an attractive target for antibiotic design

696206

drug development

Escherichia coli

-

LpxC is a target for the development of antimicrobial agents in the treatment of Gram negative infections

696210

drug development

Pseudomonas aeruginosa

-

LpxC represents a highly attractive target for a novel antibacterial drug

699420

drug development

Pseudomonas aeruginosa

-

target for development of anti-infective drugs against gram-negative bacteria

697251

drug development

Escherichia coli

-

the enzyme is a promising target for antibacterial drug development, structure-guided drug discovery of broad spectrum Gram-negative antibiotics

734239

drug development

Pseudomonas aeruginosa

P47205

the enzyme is a target for antibiotic therapy and structure-based drug design

735205

drug development

Escherichia coli R477

-

lipid A is an essential component of the outer membranes of most Gram-negative bacteria, making LpxC an attractive target for antibiotic design

-

medicine

Escherichia coli

-

LpxC is one of the key enzymes of bacterial lipid A biosynthesis, catalyzing the removal of the N-acetyl group of UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine. The lpxC gene is essential in Gram-negative bacteria but absent from mammalian genomes, making it an attractive target for antibacterial drug discovery

695538

medicine

Escherichia coli

-

this enzyme catalyzes a committed step in the biosynthesis of lipid A, and for this reason, LpxC is a target for the development of antibiotics in the treatment of Gram-negative bacterial infections

696209

medicine

Aquifex aeolicus

O67648

as it is essential for the survival of many pathogens, the enzyme is an attractive target for antibacterial therapeutics

755346

medicine

Aquifex aeolicus

O67648

promising target in the development of novel antibiotics against Gram-negative bacteria

753359

medicine

Pseudomonas aeruginosa

P47205

promising target in the development of novel antibiotics against Gram-negative bacteria

753359

medicine

Escherichia coli

P0A727

promising target in the development of novel antibiotics against Gram-negative bacteria

753359

medicine

Escherichia coli

-

the enzyme is an antibacterial drug target

752972

medicine

Pseudomonas aeruginosa ATCC 15692

-

promising target in the development of novel antibiotics against Gram-negative bacteria

-