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3.4.24.83: anthrax lethal factor endopeptidase

This is an abbreviated version!
For detailed information about anthrax lethal factor endopeptidase, go to the full flat file.

Word Map on EC 3.4.24.83

Reaction

Preferred amino acids around the cleavage site can be denoted BBBBxHx-/-H, in which B denotes Arg or Lys, H denotes a hydrophobic amino acid, and x is any amino acid. The only known protein substrates are mitogen-activated protein (MAP) kinase kinases =

Synonyms

anthrax lethal factor, anthrax lethal factor protease, anthrax lethal toxin, anthrax LF, anthrax toxin lethal factor, Bacillus anthracis lethal toxin, lethal factor, lethal factor of anthrax toxin, lethal toxin, LeTx, LF, LTx

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.24 Metalloendopeptidases
                3.4.24.83 anthrax lethal factor endopeptidase

KI Value

KI Value on EC 3.4.24.83 - anthrax lethal factor endopeptidase

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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0027
(1E,6E)-4-(1,3-dithian-2-ylidene)-1,7-difuran-2-ylhepta-1,6-diene-3,5-dione
-
-
0.0027
(1Z,6E)-4-(1,3-dithian-2-ylidene)-1,7-difuran-2-ylhepta-1,6-diene-3,5-dione
-
-
0.000000042
(2S)-6-[(1R)-N-1-(4-fluorophenyl)propan]aminoamino-2-(4-fluoro-3,5-dimethylbenzyl)-N-hydroxyhexanamide
pH not specified in the publication, temperature not specified in the publication
0.00000033
(2S)-6-[N-1-(4-fluorophenyl)propan]amino-2-[(2R)-2-(4-fluorophenyl)-2-methoxyethyl]-N-hydroxyhexanamide
pH not specified in the publication, temperature not specified in the publication
0.0011
(4E)-4-[(2,4-dihydroxyphenyl)methylidene]-1,2,5-thiadiazolidin-3-one
-
-
0.0042
(5E)-5-(1,3-benzothiazol-2-ylimino)-1-(4-sulfophenyl)-4,5-dihydro-1H-pyrazole-3-carboxylic acid
-
-
0.0011
(5Z)-5-[(2,4-dihydroxyphenyl)methylidene]-2-thioxoimidazolidin-4-one
-
-
0.0017
(9E)-N-[2-(3,4,5-trihydroxyphenyl)ethyl]octadec-9-enamide
-
-
0.0022
(9Z)-N-(3,4-dihydroxybenzyl)octadec-9-enamide
-
-
0.003
(9Z)-N-[2-(3,4-dihydroxyphenyl)ethyl]octadec-9-enamide
-
-
0.0000003
(D-Arg)9-Trp-Leu-Met-CONHOH
pH and temperature not specified in the publication
0.00000732
(D-R)9LPY-CO-NHOH
-
in 0.1 M HEPES, pH 7.4 at 37°C
0.00000145
(D-R)9VLR-CO-NHOH
-
in 0.1 M HEPES, pH 7.4 at 37°C
0.00000028
(D-R)9WLM-CO-NHOH
-
in 0.1 M HEPES, pH 7.4 at 37°C
0.0024
2-chloro-4-(5-[(Z)-[(3-cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)imino]methyl]furan-2-yl)benzoic acid
-
-
0.0025
2-chloro-4-[[(4Z)-4-[[4-(methylsulfanyl)phenyl]methylidene]-5-oxo-2-phenyl-4,5-dihydro-1H-imidazol-1-yl]sulfamoyl]benzoic acid
-
-
0.0056
2-chloro-5-(2,5-dimethyl-1H-pyrrol-1-yl)benzoic acid
-
-
0.0009
2-chloro-5-[(4Z)-3-methyl-4-[[4-(1-methylethyl)phenyl]methylidene]-5-oxo-4,5-dihydro-1H-pyrazol-1-yl]benzoic acid
-
-
0.0021 - 0.0107
2-chloro-5-[(4Z)-4-[[5-(4-chlorophenyl)furan-2-yl]methylidene]-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl]benzoic acid
0.0036
2-chloro-5-[[(4Z)-4-[[4-(methylsulfanyl)phenyl]methylidene]-5-oxo-2-phenylimidazolidin-1-yl]sulfamoyl]benzoic acid
-
-
0.0031
2-hydroxy-5-(5-[(Z)-[2-imino-4-oxo-3-(1,3-thiazol-2-yl)-1,3-thiazolidin-5-ylidene]methyl]furan-2-yl)benzoic acid
-
-
0.0031
2-hydroxy-5-[5-[(Z)-[2-imino-3-[imino(methylsulfanyl)methyl]-4-oxo-1,3-thiazolidin-5-ylidene]methyl]furan-2-yl]benzoic acid
-
-
0.011
2-thiolacetyl-YPM-amide
-
-
0.0029
2-[[(2-amino-2-carboxyethyl)sulfanyl]methyl]-5-phenylfuran-3-carboxylic acid
-
-
0.0024
3,3'-methanediylbis(6-hydroxybenzoic acid)
-
-
0.0054 - 0.0072
3-(5-[(Z)-[1-(3-chlorophenyl)-3,5-dioxopyrazolidin-4-ylidene]methyl]furan-2-yl)benzoic acid
0.0033
3-[(5E)-5-[(3-bromo-4-methoxyphenyl)methylidene]-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]propanoic acid
-
-
0.0033
3-[(5Z)-5-[(3-bromo-4-methoxyphenyl)methylidene]-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]propanoic acid
-
-
0.0015
4-(2,5-dimethyl-1H-pyrrol-1-yl)-2-hydroxybenzoic acid
-
-
0.0092
4-methyl-N-[(1R)-1-[5-(naphthalen-1-yl)-2-(prop-2-en-1-yl)tetrahydrofuran-3-yl]ethyl]benzenesulfonamide
pH and temperature not specified in the publication
-
0.0054
4-[5-[(E)-(5-cyano-2-hydroxy-4-methyl-6-oxopyridin-3(6H)-ylidene)methyl]furan-2-yl]benzenesulfonamide
-
-
0.0009
4-[[(4-chlorophenyl)carbamoyl]amino]-N-(5-ethyl-1,3,4-thiadiazol-2-yl)benzenesulfonamide
-
-
0.0024
5-(4-carboxy-3-chlorophenyl)-2-[(Z)-[(3-cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)imino]methyl]furan-3-carboxylic acid
-
-
0.0016
5-bromo-2-(5-[(Z)-[1-(3-carboxyphenyl)-5-oxo-3-(trifluoromethyl)-1,5-dihydro-4H-pyrazol-4-ylidene]methyl]furan-2-yl)benzoic acid
-
-
0.0016
5-bromo-2-(5-[(Z)-[1-(3-carboxyphenyl)-5-oxo-3-(trifluoromethyl)-1,5-dihydro-4H-pyrazol-4-ylidene]methyl]uran-2-yl)benzoic acid
-
-
0.0008 - 0.0011
5-chloro-2-[5-[(E)-(1,5-dioxo-6,7,8,9-tetrahydro-5H-[1]benzothieno[3,2-e][1,3]thiazolo[3,2-a]pyrimidin-2(1H)-ylidene)methyl]furan-2-yl]benzoic acid
0.0018
8-[(E)-[[4-(2,3-dihydro-1,3-thiazol-2-ylsulfamoyl)phenyl]imino]methyl]-4H-1,3-benzodioxine-6-carboxylic acid
-
-
0.000001
acetyl-GYbetaARRRRRRRRVLR-hydroxamate
-
-
0.036
AcG-Y-betaA-R-R-R-A-R-R-R-R-V-L-R-4-nitroanilide
-
-
0.6
AcM-L-A-R-R-R-P-V-L-P-4-nitroanilide
-
-
0.17
AcR-R-R-R-V-L-R-4-methylcoumarin-7-amide
-
-
0.19
AcR-R-R-R-V-L-R-4-nitroanilide
-
-
0.002
GM6001
-
-
140
guanidine hydrochloride
at pH 7.4 and 25°C
140
guanidine isothiocyanate
at pH 7.4 and 25°C
2 - 5
MgSO4
at pH 7.4 and 25°C
0.000001
MKARRKKVYP-NHOH
-
-
0.06
N-hydroxy-4-[2-[(9E)-octadec-9-enoylamino]ethyl]benzamide
-
-
0.0062
N-hydroxy-4-[[(9Z)-octadec-9-enoylamino]methyl]benzamide
-
-
0.003
N-oleoyldopamine
-
-
0.001
N-[3-(1,3-benzothiazol-2-yl)thiophen-2-yl]-4'-methoxy[1,1'-biphenyl]-4-sulfonamide
pH and temperature not specified in the publication
50
Na2SO4
at pH 7.4 and 25°C
150
NaCl
at pH 7.4 and 25°C
150
NaSCN
at pH 7.4 and 25°C
0.013
neamine
-
in 20 mM HEPES, pH 7.4, at 25°C
0.000007 - 0.00028
neomycin B
1050
Urea
at pH 7.4 and 25°C
0.000032
[(5Z)-5-([5-[2-chloro-5-(trifluoromethyl)phenyl]furan-2-yl]methylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]acetic acid
-
-
0.0009
[4-(2,5-dimethyl-1H-pyrrol-1-yl)phenyl]acetic acid
-
-
0.0016
[[4-(2,5-dimethyl-1H-pyrrol-1-yl)phenyl]sulfanyl]acetic acid
-
-