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Literature summary for 3.4.24.83 extracted from

  • Kuzmic, P.; Cregar, L.; Millis, S.Z.; Goldman, M.
    Mixed-type noncompetitive inhibition of anthrax lethal factor protease by aminoglycosides (2006), FEBS J., 273, 3054-3062.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
neamine mixed-type, noncompetitive inhibition Bacillus anthracis
neomycin B mixed-type, noncompetitive inhibition Bacillus anthracis

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0086
-
fluorescence resonance energy transfer peptide MAPKKide in 20 mM HEPES, pH 7.4, at 25°C Bacillus anthracis

Organism

Organism UniProt Comment Textmining
Bacillus anthracis
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
fluorescence resonance energy transfer peptide MAPKKide + H2O
-
Bacillus anthracis ?
-
?
mitogen-activated protein kinase + H2O
-
Bacillus anthracis ?
-
?

Synonyms

Synonyms Comment Organism
anthrax lethal factor protease
-
Bacillus anthracis

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00028
-
neomycin B in 20 mM HEPES, pH 7.4, at 25°C Bacillus anthracis
0.013
-
neamine in 20 mM HEPES, pH 7.4, at 25°C Bacillus anthracis