Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(1Z,6E)-4-(1,3-dithian-2-ylidene)-1,7-difuran-2-ylhepta-1,6-diene-3,5-dione | - |
Bacillus anthracis | |
(5E)-5-(1,3-benzothiazol-2-ylimino)-1-(4-sulfophenyl)-4,5-dihydro-1H-pyrazole-3-carboxylic acid | - |
Bacillus anthracis | |
(5Z)-5-[(2,4-dihydroxyphenyl)methylidene]-2-thioxoimidazolidin-4-one | - |
Bacillus anthracis | |
2-chloro-4-(5-[(Z)-[(3-cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)imino]methyl]furan-2-yl)benzoic acid | - |
Bacillus anthracis | |
2-chloro-4-[[(4Z)-4-[[4-(methylsulfanyl)phenyl]methylidene]-5-oxo-2-phenyl-4,5-dihydro-1H-imidazol-1-yl]sulfamoyl]benzoic acid | - |
Bacillus anthracis | |
2-chloro-5-(2,5-dimethyl-1H-pyrrol-1-yl)benzoic acid | - |
Bacillus anthracis | |
2-chloro-5-[(4Z)-3-methyl-4-[[4-(1-methylethyl)phenyl]methylidene]-5-oxo-4,5-dihydro-1H-pyrazol-1-yl]benzoic acid | - |
Bacillus anthracis | |
2-chloro-5-[(4Z)-4-[[5-(4-chlorophenyl)furan-2-yl]methylidene]-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl]benzoic acid | - |
Bacillus anthracis | |
2-hydroxy-5-(5-[(Z)-[2-imino-4-oxo-3-(1,3-thiazol-2-yl)-1,3-thiazolidin-5-ylidene]methyl]furan-2-yl)benzoic acid | - |
Bacillus anthracis | |
2-[[(2-amino-2-carboxyethyl)sulfanyl]methyl]-5-phenylfuran-3-carboxylic acid | - |
Bacillus anthracis | |
3,3'-methanediylbis(6-hydroxybenzoic acid) | - |
Bacillus anthracis | |
3-(5-[(Z)-[1-(3-chlorophenyl)-3,5-dioxopyrazolidin-4-ylidene]methyl]furan-2-yl)benzoic acid | - |
Bacillus anthracis | |
3-[(5E)-5-[(3-bromo-4-methoxyphenyl)methylidene]-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]propanoic acid | - |
Bacillus anthracis | |
4-(2,5-dimethyl-1H-pyrrol-1-yl)-2-hydroxybenzoic acid | - |
Bacillus anthracis | |
4-[5-[(E)-(5-cyano-2-hydroxy-4-methyl-6-oxopyridin-3(6H)-ylidene)methyl]furan-2-yl]benzenesulfonamide | - |
Bacillus anthracis | |
4-[[(4-chlorophenyl)carbamoyl]amino]-N-(5-ethyl-1,3,4-thiadiazol-2-yl)benzenesulfonamide | - |
Bacillus anthracis | |
5-bromo-2-(5-[(Z)-[1-(3-carboxyphenyl)-5-oxo-3-(trifluoromethyl)-1,5-dihydro-4H-pyrazol-4-ylidene]methyl]furan-2-yl)benzoic acid | - |
Bacillus anthracis | |
5-chloro-2-[5-[(E)-(1,5-dioxo-6,7,8,9-tetrahydro-5H-[1]benzothieno[3,2-e][1,3]thiazolo[3,2-a]pyrimidin-2(1H)-ylidene)methyl]furan-2-yl]benzoic acid | - |
Bacillus anthracis | |
8-[(E)-[[4-(2,3-dihydro-1,3-thiazol-2-ylsulfamoyl)phenyl]imino]methyl]-4H-1,3-benzodioxine-6-carboxylic acid | - |
Bacillus anthracis | |
[4-(2,5-dimethyl-1H-pyrrol-1-yl)phenyl]acetic acid | - |
Bacillus anthracis | |
[[4-(2,5-dimethyl-1H-pyrrol-1-yl)phenyl]sulfanyl]acetic acid | - |
Bacillus anthracis |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | dependent | Bacillus anthracis |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bacillus anthracis | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
mitogen-activated protein kinase kinase + H2O | - |
Bacillus anthracis | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
anthrax lethal factor | - |
Bacillus anthracis |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0008 | - |
5-chloro-2-[5-[(E)-(1,5-dioxo-6,7,8,9-tetrahydro-5H-[1]benzothieno[3,2-e][1,3]thiazolo[3,2-a]pyrimidin-2(1H)-ylidene)methyl]furan-2-yl]benzoic acid | - |
Bacillus anthracis | |
0.0009 | - |
2-chloro-5-[(4Z)-3-methyl-4-[[4-(1-methylethyl)phenyl]methylidene]-5-oxo-4,5-dihydro-1H-pyrazol-1-yl]benzoic acid | - |
Bacillus anthracis | |
0.0009 | - |
4-[[(4-chlorophenyl)carbamoyl]amino]-N-(5-ethyl-1,3,4-thiadiazol-2-yl)benzenesulfonamide | - |
Bacillus anthracis | |
0.0009 | - |
[4-(2,5-dimethyl-1H-pyrrol-1-yl)phenyl]acetic acid | - |
Bacillus anthracis | |
0.0011 | - |
(5Z)-5-[(2,4-dihydroxyphenyl)methylidene]-2-thioxoimidazolidin-4-one | - |
Bacillus anthracis | |
0.0015 | - |
4-(2,5-dimethyl-1H-pyrrol-1-yl)-2-hydroxybenzoic acid | - |
Bacillus anthracis | |
0.0016 | - |
[[4-(2,5-dimethyl-1H-pyrrol-1-yl)phenyl]sulfanyl]acetic acid | - |
Bacillus anthracis | |
0.0016 | - |
5-bromo-2-(5-[(Z)-[1-(3-carboxyphenyl)-5-oxo-3-(trifluoromethyl)-1,5-dihydro-4H-pyrazol-4-ylidene]methyl]furan-2-yl)benzoic acid | - |
Bacillus anthracis | |
0.0018 | - |
8-[(E)-[[4-(2,3-dihydro-1,3-thiazol-2-ylsulfamoyl)phenyl]imino]methyl]-4H-1,3-benzodioxine-6-carboxylic acid | - |
Bacillus anthracis | |
0.0021 | - |
2-chloro-5-[(4Z)-4-[[5-(4-chlorophenyl)furan-2-yl]methylidene]-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl]benzoic acid | - |
Bacillus anthracis | |
0.0024 | - |
3,3'-methanediylbis(6-hydroxybenzoic acid) | - |
Bacillus anthracis | |
0.0024 | - |
2-chloro-4-(5-[(Z)-[(3-cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)imino]methyl]furan-2-yl)benzoic acid | - |
Bacillus anthracis | |
0.0025 | - |
2-chloro-4-[[(4Z)-4-[[4-(methylsulfanyl)phenyl]methylidene]-5-oxo-2-phenyl-4,5-dihydro-1H-imidazol-1-yl]sulfamoyl]benzoic acid | - |
Bacillus anthracis | |
0.0027 | - |
(1Z,6E)-4-(1,3-dithian-2-ylidene)-1,7-difuran-2-ylhepta-1,6-diene-3,5-dione | - |
Bacillus anthracis | |
0.0029 | - |
2-[[(2-amino-2-carboxyethyl)sulfanyl]methyl]-5-phenylfuran-3-carboxylic acid | - |
Bacillus anthracis | |
0.0031 | - |
2-hydroxy-5-(5-[(Z)-[2-imino-4-oxo-3-(1,3-thiazol-2-yl)-1,3-thiazolidin-5-ylidene]methyl]furan-2-yl)benzoic acid | - |
Bacillus anthracis | |
0.0033 | - |
3-[(5E)-5-[(3-bromo-4-methoxyphenyl)methylidene]-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]propanoic acid | - |
Bacillus anthracis | |
0.0042 | - |
(5E)-5-(1,3-benzothiazol-2-ylimino)-1-(4-sulfophenyl)-4,5-dihydro-1H-pyrazole-3-carboxylic acid | - |
Bacillus anthracis | |
0.0054 | - |
4-[5-[(E)-(5-cyano-2-hydroxy-4-methyl-6-oxopyridin-3(6H)-ylidene)methyl]furan-2-yl]benzenesulfonamide | - |
Bacillus anthracis | |
0.0056 | - |
2-chloro-5-(2,5-dimethyl-1H-pyrrol-1-yl)benzoic acid | - |
Bacillus anthracis | |
0.0072 | - |
3-(5-[(Z)-[1-(3-chlorophenyl)-3,5-dioxopyrazolidin-4-ylidene]methyl]furan-2-yl)benzoic acid | - |
Bacillus anthracis |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0008 | - |
- |
Bacillus anthracis | 5-chloro-2-[5-[(E)-(1,5-dioxo-6,7,8,9-tetrahydro-5H-[1]benzothieno[3,2-e][1,3]thiazolo[3,2-a]pyrimidin-2(1H)-ylidene)methyl]furan-2-yl]benzoic acid | |
0.0017 | - |
- |
Bacillus anthracis | 5-bromo-2-(5-[(Z)-[1-(3-carboxyphenyl)-5-oxo-3-(trifluoromethyl)-1,5-dihydro-4H-pyrazol-4-ylidene]methyl]furan-2-yl)benzoic acid | |
0.0029 | - |
- |
Bacillus anthracis | [[4-(2,5-dimethyl-1H-pyrrol-1-yl)phenyl]sulfanyl]acetic acid | |
0.003 | - |
- |
Bacillus anthracis | (1Z,6E)-4-(1,3-dithian-2-ylidene)-1,7-difuran-2-ylhepta-1,6-diene-3,5-dione | |
0.0031 | - |
- |
Bacillus anthracis | 3,3'-methanediylbis(6-hydroxybenzoic acid) | |
0.0034 | - |
- |
Bacillus anthracis | (5Z)-5-[(2,4-dihydroxyphenyl)methylidene]-2-thioxoimidazolidin-4-one | |
0.0036 | - |
- |
Bacillus anthracis | 2-[[(2-amino-2-carboxyethyl)sulfanyl]methyl]-5-phenylfuran-3-carboxylic acid | |
0.0036 | - |
- |
Bacillus anthracis | 2-chloro-4-[[(4Z)-4-[[4-(methylsulfanyl)phenyl]methylidene]-5-oxo-2-phenyl-4,5-dihydro-1H-imidazol-1-yl]sulfamoyl]benzoic acid | |
0.0039 | - |
- |
Bacillus anthracis | 4-[[(4-chlorophenyl)carbamoyl]amino]-N-(5-ethyl-1,3,4-thiadiazol-2-yl)benzenesulfonamide | |
0.0042 | - |
- |
Bacillus anthracis | 2-chloro-4-(5-[(Z)-[(3-cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)imino]methyl]furan-2-yl)benzoic acid | |
0.0043 | - |
- |
Bacillus anthracis | 4-(2,5-dimethyl-1H-pyrrol-1-yl)-2-hydroxybenzoic acid | |
0.0044 | - |
- |
Bacillus anthracis | 3-[(5E)-5-[(3-bromo-4-methoxyphenyl)methylidene]-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]propanoic acid | |
0.0048 | - |
- |
Bacillus anthracis | 2-hydroxy-5-(5-[(Z)-[2-imino-4-oxo-3-(1,3-thiazol-2-yl)-1,3-thiazolidin-5-ylidene]methyl]furan-2-yl)benzoic acid | |
0.0068 | - |
- |
Bacillus anthracis | 2-chloro-5-(2,5-dimethyl-1H-pyrrol-1-yl)benzoic acid | |
0.0076 | - |
- |
Bacillus anthracis | [4-(2,5-dimethyl-1H-pyrrol-1-yl)phenyl]acetic acid | |
0.0077 | - |
- |
Bacillus anthracis | (5E)-5-(1,3-benzothiazol-2-ylimino)-1-(4-sulfophenyl)-4,5-dihydro-1H-pyrazole-3-carboxylic acid | |
0.0079 | - |
- |
Bacillus anthracis | 2-chloro-5-[(4Z)-3-methyl-4-[[4-(1-methylethyl)phenyl]methylidene]-5-oxo-4,5-dihydro-1H-pyrazol-1-yl]benzoic acid | |
0.0083 | - |
- |
Bacillus anthracis | 4-[5-[(E)-(5-cyano-2-hydroxy-4-methyl-6-oxopyridin-3(6H)-ylidene)methyl]furan-2-yl]benzenesulfonamide | |
0.0093 | - |
- |
Bacillus anthracis | 8-[(E)-[[4-(2,3-dihydro-1,3-thiazol-2-ylsulfamoyl)phenyl]imino]methyl]-4H-1,3-benzodioxine-6-carboxylic acid | |
0.0105 | - |
- |
Bacillus anthracis | 3-(5-[(Z)-[1-(3-chlorophenyl)-3,5-dioxopyrazolidin-4-ylidene]methyl]furan-2-yl)benzoic acid | |
0.0107 | - |
- |
Bacillus anthracis | 2-chloro-5-[(4Z)-4-[[5-(4-chlorophenyl)furan-2-yl]methylidene]-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl]benzoic acid |