3.4.24.83: anthrax lethal factor endopeptidase
This is an abbreviated version!
For detailed information about anthrax lethal factor endopeptidase, go to the full flat file.
Word Map on EC 3.4.24.83
-
3.4.24.83
-
edema
-
spore
-
intoxication
-
endosomal
-
exotoxin
-
metalloprotease
-
inhalation
-
inflammasome
-
endocytosis
-
toxin-induced
-
anti-pa
-
heptameric
-
caspase-1
-
sterne
-
furin
-
mapkks
-
lt-induced
-
tripartite
-
diphtheria
-
toxin-mediated
-
spore-forming
-
pyroptosis
-
toxemia
-
ring-shaped
-
receptor-bound
-
toxin-neutralizing
-
zinc-dependent
-
molecular biology
-
cytolysis
-
pa-binding
-
medicine
-
mkk
-
bioterrorism
-
diagnostics
-
toxin-sensitive
-
synthesis
-
postexposure
-
cell-binding
- 3.4.24.83
-
edema
- spore
-
intoxication
- endosomal
-
exotoxin
- metalloprotease
-
inhalation
- inflammasome
-
endocytosis
-
toxin-induced
-
anti-pa
-
heptameric
- caspase-1
- sterne
- furin
- mapkks
-
lt-induced
-
tripartite
- diphtheria
-
toxin-mediated
-
spore-forming
-
pyroptosis
- toxemia
-
ring-shaped
-
receptor-bound
-
toxin-neutralizing
-
zinc-dependent
- molecular biology
-
cytolysis
-
pa-binding
- medicine
- mkk
-
bioterrorism
- diagnostics
-
toxin-sensitive
- synthesis
-
postexposure
-
cell-binding
Reaction
Preferred amino acids around the cleavage site can be denoted BBBBxHx-/-H, in which B denotes Arg or Lys, H denotes a hydrophobic amino acid, and x is any amino acid. The only known protein substrates are mitogen-activated protein (MAP) kinase kinases =
Synonyms
anthrax lethal factor, anthrax lethal factor protease, anthrax lethal toxin, anthrax LF, anthrax toxin lethal factor, Bacillus anthracis lethal toxin, lethal factor, lethal factor of anthrax toxin, lethal toxin, LeTx, LF, LTx
ECTree
3.4.24.83 anthrax lethal factor endopeptidaseAdvanced search results
results (
results (Reference
top
Reference on EC 3.4.24.83 - anthrax lethal factor endopeptidase
Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Vitale, G.; Bernardi, L.; Napolitani, G.; Mock, M.; Montecucco, C.
Susceptibility of mitogen-activated protein kinase kinase family members to proteolysis by anthrax lethal factor
Biochem. J.
352
739-745
2000
Bacillus anthracis
Duesbery, N.S.; Webb, C.P.; Leppla, S.H.; Gordon, V.M.; Klimpel, K.R.; Copeland, T.D.; Ahn, N.G.; Oskarsson, M.K.; Fukasawa, K.; Paull, K.D.; Vande Woude, G.F.
Proteolytic inactivation of MAP-kinase-kinase by anthrax lethal factor
Science
280
734-737
1998
Bacillus anthracis
Pannifer, A.D.; Wong, T.Y.; Schwarzenbacher, R.; Renatus, M.; Petosa, C.; Bienkowska, J.; Lacy, D.B.; Collier, R.J.; Park, S.; Leppla, S.H.; Hanna, P.; Liddington, R.C.
Crystal structure of the anthrax lethal factor
Nature
414
229-233
2001
Bacillus anthracis
Tonello, F.; Ascenzi, P.; Montecucco, C.
The metalloproteolytic activity of the anthrax lethal factor is substrate-inhibited
J. Biol. Chem.
278
40075-40078
2003
Bacillus anthracis
Pellizzari, R.; Guidi-Rontani, C.; Vitale, G.; Mock, M.; Montecucco, C.
Anthrax lethal factor cleaves MKK3 in macrophages and inhibits the LPS/IFNgamma-induced release of NO and TNFalpha
FEBS Lett.
462
199-204
1999
Bacillus anthracis
Rossetto, O.; de Bernard, M.; Pellizzari, R.; Vitale, G.; Caccin, P.; Schiavo, G.; Montecucco, C.
Bacterial toxins with intracellular protease activity
Clin. Chim. Acta
291
189-199
2000
Bacillus anthracis
Glomski, I.J.; Fritz, J.H.; Keppler, S.J.; Balloy, V.; Chignard, M.; Mock, M.; Goossens, P.L.
Murine splenocytes produce inflammatory cytokines in MyD88-dependent response to Bacillus anthracis spores
cell. Microbiol.
9
502-513
2007
Bacillus anthracis
Gubbins, M.J.; Berry, J.D.; Corbett, C.R.; Mogridge, J.; Yuan, X.Y.; Schmidt, L.; Nicolas, B.; Kabani, A.; Tsang, R.S.
Production and characterization of neutralizing monoclonal antibodies that recognize an epitope in domain 2 of Bacillus anthracis protective antigen
FEMS Immunol. Med. Microbiol.
47
436-443
2006
Bacillus anthracis
Bergman, N.H.; Passalacqua, K.D.; Gaspard, R.; Shetron-Rama, L.M.; Quackenbush, J.; Hanna, P.C.
Murine macrophage transcriptional responses to Bacillus anthracis infection and intoxication
Infect. Immun.
73
1069-1080
2005
Bacillus anthracis
Comer, J.E.; Galindo, C.L.; Chopra, A.K.; Peterson, J.W.
GeneChip analyses of global transcriptional responses of murine macrophages to the lethal toxin of Bacillus anthracis
Infect. Immun.
73
1879-1885
2005
Bacillus anthracis
Koya, V.; Moayeri, M.; Leppla, S.H.; Daniell, H.
Plant-based vaccine: mice immunized with chloroplast-derived anthrax protective antigen survive anthrax lethal toxin challenge
Infect. Immun.
73
8266-8274
2005
Bacillus anthracis
Xu, L.; Frucht, D.M.
Bacillus anthracis: A multi-faceted role for anthrax lethal toxin in thwarting host immune defenses
Int. J. Biochem. Cell Biol.
39
20-24
2007
Bacillus anthracis
Baillie, L.W.J.
Past, imminent and future human medical countermeasures for anthrax
J. Appl. Microbiol.
101
594-606
2006
Bacillus anthracis
Cui, X.; Li, Y.; Li, X.; Haley, M.; Moayeri, M.; Fitz, Y.; Leppla, S.H.; Eichacker, P.Q.
Sublethal doses of Bacillus anthracis lethal toxin inhibit inflammation with lipopolysaccharide and Escherichia coli challenge but have opposite effects on survival
J. Infect. Dis.
193
829-840
2006
Bacillus anthracis
Gujraty, K.; Sadacharan, S.; Frost, M.; Poon, V.; kane, R.S.; Mogridge, J.
Functional characterization of peptide-based anthrax toxin inhibitors
Mol. Pharmacol.
2
367-372
2005
Bacillus anthracis
-
Boyden, E.D.; Dietrich, W.F.
Nalp1b controls mouse macrophage susceptibility to anthrax lethal toxin
Nat. Genet.
38
240-244
2006
Bacillus subtilis
Mendelson, I.; Gat, O.; Aloni-Grinstein, R.; Altboum, Z.; Inbar, I.; Kronman, C.; Bar-Haim, E.; Cohen, S.; Velan, B.; Shafferman, A.
Efficacious, nontoxigenic Bacillus anthracis spore vaccines based on strains expressing mutant variants of lethal toxin components
Vaccine
23
5688-5697
2005
Bacillus anthracis
Sloat, B.R.; Cui, Z.
Nasal immunozation with a dual antigen anthrax vaccine induced strong mucosal and systemic immune responses against toxins and bacilli
Vaccine
24
6405-6413
2006
Bacillus anthracis
Moayeri, M.; Robinson, T.M.; Leppla, S.H.; Karginov, V.A.
In vivo efficacy of beta-cyclodextrin derivatives against anthrax lethal toxin
Antimicrob. Agents Chemother.
52
2239-2241
2008
Bacillus anthracis
Chvyrkova, I.; Zhang, X.C.; Terzyan, S.
Lethal factor of anthrax toxin binds monomeric form of protective antigen
Biochem. Biophys. Res. Commun.
360
690-695
2007
Bacillus anthracis (Q52NH3), Bacillus anthracis
Karginov, V.A.; Nestorovich, E.M.; Schmidtmann, F.; Robinson, T.M.; Yohannes, A.; Fahmi, N.E.; Bezrukov, S.M.; Hecht, S.M.
Inhibition of S. aureus alpha-hemolysin and B. anthracis lethal toxin by beta-cyclodextrin derivatives
Bioorg. Med. Chem.
15
5424-5431
2007
Bacillus anthracis
Gaddis, B.D.; Avramova, L.V.; Chmielewski, J.
Inhibitors of anthrax lethal factor
Bioorg. Med. Chem. Lett.
17
4575-4578
2007
Bacillus anthracis
Muehlbauer, S.M.; Evering, T.H.; Bonuccelli, G.; Squires, R.C.; Ashton, A.W.; Porcelli, S.A.; Lisanti, M.P.; Brojatsch, J.
Anthrax lethal toxin kills macrophages in a strain-specific manner by apoptosis or caspase-1-mediated necrosis
Cell Cycle
6
758-766
2007
Bacillus anthracis
Wickliffe, K.E.; Leppla, S.H.; Moayeri, M.
Anthrax lethal toxin-induced inflammasome formation and caspase-1 activation are late events dependent on ion fluxes and the proteasome
Cell. Microbiol.
10
332-343
2008
Bacillus anthracis
Rossi Paccani, S.; Tonello, F.; Patrussi, L.; Capitani, N.; Simonato, M.; Montecucco, C.; Baldari, C.T.
Anthrax toxins inhibit immune cell chemotaxis by perturbing chemokine receptor signalling
Cell. Microbiol.
9
924-929
2007
Bacillus anthracis
During, R.L.; Gibson, B.G.; Li, W.; Bishai, E.A.; Sidhu, G.S.; Landry, J.; Southwick, F.S.
Anthrax lethal toxin paralyzes actin-based motility by blocking Hsp27 phosphorylation
EMBO J.
26
2240-2250
2007
Bacillus anthracis
Kuzmic, P.; Cregar, L.; Millis, S.Z.; Goldman, M.
Mixed-type noncompetitive inhibition of anthrax lethal factor protease by aminoglycosides
FEBS J.
273
3054-3062
2006
Bacillus anthracis
Juris, S.J.; Melnyk, R.A.; Bolcome, R.E.; Chan, J.; Collier, R.J.
Cross-linked forms of the isolated N-terminal domain of the lethal factor are potent inhibitors of anthrax toxin
Infect. Immun.
75
5052-5058
2007
Bacillus anthracis
Liu, S.; Wang, H.; Currie, B.M.; Molinolo, A.; Leung, H.J.; Moayeri, M.; Basile, J.R.; Alfano, R.W.; Gutkind, J.S.; Frankel, A.E.; Bugge, T.H.; Leppla, S.H.
Matrix metalloproteinase-activated anthrax lethal toxin demonstrates high potency in targeting tumor vasculature
J. Biol. Chem.
283
529-540
2008
Bacillus anthracis
Chang, H.H.; Tsai, M.F.; Chung, C.P.; Chen, P.K.; Hu, H.I.; Kau, J.H.; Huang, H.H.; Lin, H.C.; Sun, D.S.
Single-step purification of recombinant anthrax lethal factor from periplasm of Escherichia coli
J. Biotechnol.
126
277-285
2006
Bacillus anthracis
Schepetkin, I.A.; Khlebnikov, A.I.; Kirpotina, L.N.; Quinn, M.T.
Novel small-molecule inhibitors of anthrax lethal factor identified by high-throughput screening
J. Med. Chem.
49
5232-5244
2006
Bacillus anthracis
Dalkas, G.A.; Papakyriakou, A.; Vlamis-Gardikas, A.; Spyroulias, G.A.
Low molecular weight inhibitors of the protease anthrax lethal factor
Mini Rev. Med. Chem.
8
290-306
2008
Bacillus anthracis
Alfano, R.W.; Leppla, S.H.; Liu, S.; Bugge, T.H.; Herlyn, M.; Smalley, K.S.; Bromberg-White, J.L.; Duesbery, N.S.; Frankel, A.E.
Cytotoxicity of the matrix metalloproteinase-activated anthrax lethal toxin is dependent on gelatinase expression and B-RAF status in human melanoma cells
Mol. Cancer Ther.
7
1218-1226
2008
Bacillus anthracis
Guichard, A.; Park, J.M.; Cruz-Moreno, B.; Karin, M.; Bier, E.
Anthrax lethal factor and edema factor act on conserved targets in Drosophila
Proc. Natl. Acad. Sci. USA
103
3244-3249
2006
Bacillus anthracis
Bolcome, R.E.; Sullivan, S.E.; Zeller, R.; Barker, A.P.; Collier, R.J.; Chan, J.
Anthrax lethal toxin induces cell death-independent permeability in zebrafish vasculature
Proc. Natl. Acad. Sci. USA
105
2439-2444
2008
Bacillus anthracis
Fink, S.L.; Bergsbaken, T.; Cookson, B.T.
Anthrax lethal toxin and Salmonella elicit the common cell death pathway of caspase-1-dependent pyroptosis via distinct mechanisms
Proc. Natl. Acad. Sci. USA
105
4312-4317
2008
Bacillus anthracis
Barson, H.V.; Mollenkopf, H.; Kaufmann, S.H.; Rijpkema, S.
Anthrax lethal toxin suppresses chemokine production in human neutrophil NB-4 cells
Biochem. Biophys. Res. Commun.
374
288-293
2008
Bacillus anthracis
Tan, Y.K.; Kusuma, C.M.; St John, L.J.; Vu, H.A.; Alibek, K.; Wu, A.
Induction of autophagy by anthrax lethal toxin
Biochem. Biophys. Res. Commun.
379
293-297
2009
Bacillus anthracis
Jung, K.H.; Seo, G.M.; Yoon, J.W.; Park, K.S.; Kim, J.C.; Kim, S.J.; Oh, K.G.; Lee, J.H.; Chai, Y.G.
Protein expression pattern of murine macrophages treated with anthrax lethal toxin
Biochim. Biophys. Acta
1784
1501-1506
2008
Bacillus anthracis
Gaddis, B.D.; Rubert Perez, C.M.; Chmielewski, J.
Inhibitors of anthrax lethal factor based upon N-oleoyldopamine
Bioorg. Med. Chem. Lett.
18
2467-2470
2008
Bacillus anthracis
Reig, N.; Jiang, A.; Couture, R.; Sutterwala, F.S.; Ogura, Y.; Flavell, R.A.; Mellman, I.; van der Goot, F.G.
Maturation modulates caspase-1-independent responses of dendritic cells to Anthrax lethal toxin
Cell. Microbiol.
10
1190-1207
2008
Bacillus anthracis
Wickliffe, K.E.; Leppla, S.H.; Moayeri, M.
Killing of macrophages by anthrax lethal toxin: involvement of the N-end rule pathway
Cell. Microbiol.
10
1352-1362
2008
Bacillus anthracis
Levin, T.C.; Wickliffe, K.E.; Leppla, S.H.; Moayeri, M.
Heat shock inhibits caspase-1 activity while also preventing its inflammasome-mediated activation by anthrax lethal toxin
Cell. Microbiol.
10
2434-2446
2008
Bacillus anthracis
Omland, K.S.; Brys, A.; Lansky, D.; Clement, K.; Lynn, F.; Lynn, F.
Interlaboratory comparison of results of an anthrax lethal toxin neutralization assay for assessment of functional antibodies in multiple species
Clin. Vaccine Immunol.
15
946-953
2008
Bacillus anthracis
Chou, P.J.; Newton, C.A.; Perkins, I.; Friedman, H.; Klein, T.W.
Suppression of dendritic cell activation by anthrax lethal toxin and edema toxin depends on multiple factors including cell source, stimulus used, and function tested
DNA Cell Biol.
27
637-648
2008
Bacillus anthracis
Shaw, C.A.; Starnbach, M.N.
Both CD4+ and CD8+ T cells respond to antigens fused to anthrax lethal toxin
Infect. Immun.
76
2603-2611
2008
Bacillus anthracis
Nour, A.M.; Yeung, Y.G.; Santambrogio, L.; Boyden, E.D.; Stanley, E.R.; Brojatsch, J.
Anthrax lethal toxin triggers the formation of a membrane-associated inflammasome complex in murine macrophages
Infect. Immun.
77
1262-1271
2009
Bacillus anthracis
deCathelineau, A.M.; Bokoch, G.M.
Inactivation of rho GTPases by statins attenuates anthrax lethal toxin activity
Infect. Immun.
77
348-359
2009
Bacillus anthracis
Kocer, S.S.; Matic, M.; Ingrassia, M.; Walker, S.G.; Roemer, E.; Licul, G.; Simon, S.R.
Effects of anthrax lethal toxin on human primary keratinocytes
J. Appl. Microbiol.
105
1756-1767
2008
Bacillus anthracis
Xu, L.; Fang, H.; Frucht, D.M.
Anthrax lethal toxin increases superoxide production in murine neutrophils via differential effects on MAPK signaling pathways
J. Immunol.
180
4139-4147
2008
Bacillus anthracis
Warfel, J.M.; DAgnillo, F.
Anthrax lethal toxin enhances TNF-induced endothelial VCAM-1 expression via an IFN regulatory factor-1-dependent mechanism
J. Immunol.
180
7516-7524
2008
Bacillus anthracis
Alfano, R.W.; Leppla, S.H.; Liu, S.; Bugge, T.H.; Meininger, C.J.; Lairmore, T.C.; Mulne, A.F.; Davis, S.H.; Duesbery, N.S.; Frankel, A.E.
Matrix metalloproteinase-activated anthrax lethal toxin inhibits endothelial invasion and neovasculature formation during in vitro morphogenesis
Mol. Cancer Res.
7
452-461
2009
Bacillus anthracis
Chapelsky, S.; Batty, S.; Frost, M.; Mogridge, J.
Inhibition of anthrax lethal toxin-induced cytolysis of RAW264.7 cells by celastrol
PLoS ONE
3
e1421
2008
Bacillus anthracis
Raymond, B.; Batsche, E.; Boutillon, F.; Wu, Y.Z.; Leduc, D.; Balloy, V.; Raoust, E.; Muchardt, C.; Goossens, P.L.; Touqui, L.
Anthrax lethal toxin impairs IL-8 expression in epithelial cells through inhibition of histone H3 modification
PLoS Pathog.
5
e1000359
2009
Bacillus anthracis
Ha, S.D.; Ham, B.; Mogridge, J.; Saftig, P.; Lin, S.; Kim, S.O.
Cathepsin B-mediated autophagy flux facilitates the anthrax toxin receptor 2-mediated delivery of anthrax lethal factor into the cytoplasm
J. Biol. Chem.
285
2120-2129
2010
Bacillus anthracis
Pentelute, B.L.; Barker, A.P.; Janowiak, B.E.; Kent, S.B.; Collier, R.J.
A semisynthesis platform for investigating structure-function relationships in the N-terminal domain of the anthrax Lethal Factor
ACS Chem. Biol.
5
359-364
2010
Bacillus anthracis
Raymond, B.; Ravaux, L.; Memet, S.; Wu, Y.; Sturny-Leclere, A.; Leduc, D.; Denoyelle, C.; Goossens, P.L.; Paya, M.; Raymondjean, M.; Touqui, L.
Anthrax lethal toxin down-regulates type-IIA secreted phospholipase A(2) expression through MAPK/NF-kappaB inactivation
Biochem. Pharmacol.
79
1149-1155
2010
Bacillus anthracis
Ngai, S.; Batty, S.; Liao, K.C.; Mogridge, J.
An anthrax lethal factor mutant that is defective at causing pyroptosis retains proapoptotic activity
FEBS J.
277
119-127
2010
Bacillus anthracis
Kong, Y.; Guo, Q.; Yu, C.; Dong, D.; Zhao, J.; Cai, C.; Hou, L.; Song, X.; Fu, L.; Xu, J.; Chen, W.
Fusion protein of DELTA 27LFn and EFn has the potential as a novel anthrax toxin inhibitor
FEBS Lett.
583
1257-1260
2009
Bacillus anthracis
Zakharova, M.Y.; Kuznetsov, N.A.; Dubiley, S.A.; Kozyr, A.V.; Fedorova, O.S.; Chudakov, D.M.; Knorre, D.G.; Shemyakin, I.G.; Gabibov, A.G.; Kolesnikov, A.V.
Substrate recognition of anthrax lethal factor examined by combinatorial and pre-steady-state kinetic approaches
J. Biol. Chem.
284
17902-17913
2009
Bacillus anthracis
Chiu, T.L.; Solberg, J.; Patil, S.; Geders, T.W.; Zhang, X.; Rangarajan, S.; Francis, R.; Finzel, B.C.; Walters, M.A.; Hook, D.J.; Amin, E.A.
Identification of novel non-hydroxamate anthrax toxin lethal factor inhibitors by topomeric searching, docking and scoring, and in vitro screening
J. Chem. Inf. Model.
49
2726-2734
2009
Bacillus anthracis
Hu, H.; Leppla, S.H.
Anthrax toxin uptake by primary immune cells as determined with a lethal factor-beta-lactamase fusion protein
PLoS ONE
4
e7946
2009
Bacillus anthracis
Moayeri, M.; Crown, D.; Dorward, D.W.; Gardner, D.; Ward, J.M.; Li, Y.; Cui, X.; Eichacker, P.; Leppla, S.H.
The heart is an early target of anthrax lethal toxin in mice: a protective role for neuronal nitric oxide synthase (nNOS)
PLoS Pathog.
5
e1000456
2009
Bacillus anthracis
Abrami, L.; Kunz, B.; van der Goot, F.G.
Anthrax toxin triggers the activation of src-like kinases to mediate its own uptake
Proc. Natl. Acad. Sci. USA
107
1420-1424
2010
Bacillus anthracis
Dalkas, G.A.; Papakyriakou, A.; Vlamis-Gardikas, A.; Spyroulias, G.A.
Insights into the anthrax lethal factor-substrate interaction and selectivity using docking and molecular dynamics simulations
Protein Sci.
18
1774-1785
2009
Bacillus anthracis
Kuklenyik, Z.; Boyer, A.E.; Lins, R.; Quinn, C.P.; Gallegos-Candela, M.; Woolfitt, A.; Pirkle, J.L.; Barr, J.R.
Comparison of MALDI-TOF-MS and HPLC-ESI-MS/MS for endopeptidase activity-based quantification of anthrax lethal factor in serum
Anal. Chem.
83
1760-1765
2011
Bacillus anthracis
Li, F.; Terzyan, S.; Tang, J.
Subsite specificity of anthrax lethal factor and its implications for inhibitor development
Biochem. Biophys. Res. Commun.
407
400-405
2011
Bacillus anthracis
Saebel, C.E.; Carbone, R.; Dabous, J.R.; Lo, S.Y.; Siemann, S.
Preparation and characterization of cobalt-substituted anthrax lethal factor
Biochem. Biophys. Res. Commun.
416
106-110
2011
Bacillus anthracis
Dalkas, G.A.; Chasapis, C.T.; Gkazonis, P.V.; Bentrop, D.; Spyroulias, G.A.
Conformational dynamics of the anthrax lethal factor catalytic center
Biochemistry
49
10767-10769
2010
Bacillus anthracis (P15917)
Little, S.F.; Webster, W.M.; Fisher, D.E.
Monoclonal antibodies directed against protective antigen of Bacillus anthracis enhance lethal toxin activity in vivo
FEMS Immunol. Med. Microbiol.
62
11-22
2011
Bacillus anthracis, Bacillus anthracis BH450
Liu, T.; Milia, E.; Warburton, R.R.; Hill, N.S.; Gaestel, M.; Kayyali, U.S.
Anthrax lethal toxin disrupts the endothelial permeability barrier through blocking p38 signaling
J. Cell. Physiol.
227
1438-1445
2012
Bacillus anthracis
Thomas, J.; Epshtein, Y.; Chopra, A.; Ordog, B.; Ghassemi, M.; Christman, J.W.; Nattel, S.; Cook, J.L.; Levitan, I.
Anthrax lethal factor activates K+ channels to induce IL-1beta secretion in macrophages
J. Immunol.
186
5236-5243
2011
Bacillus anthracis
Vuyisich, M.; Sanders, C.; Graves, S.
Binding and cell intoxication studies of anthrax lethal toxin
Mol. Biol. Rep.
2012
1-7
2012
Bacillus anthracis
Guichard, A.; McGillivray, S.; Cruz-Moreno, B.; Van Sorge, N.; Nizet, V.; Bier, E.
Anthrax toxins cooperatively inhibit endocytic recycling by the Rab11/Sec15 exocyst
Nature
467
854-858
2010
Bacillus anthracis
Rivera, J.; Cordero, R.; Nakouzi, A.; Frases, S.; Nicola, A.; Casadevall, A.
Bacillus anthracis produces membrane-derived vesicles containing biologically active toxins
Proc. Natl. Acad. Sci. USA
107
19002-19007
2010
Bacillus anthracis, Bacillus anthracis 34F2
Bromberg-White, J.; Lee, C.S.; Duesbery, N.
Consequences and utility of the zinc-dependent metalloprotease activity of anthrax lethal toxin
Toxins
2
1038-1053
2010
Bacillus anthracis
Xie, T.; Auth, R.D.; Frucht, D.M.
The effects of anthrax lethal toxin on host barrier function
Toxins
3
591-607
2011
Bacillus anthracis
Maize, K.; Kurbanov, E.; De La Mora-Rey, T.; Geders, T.; Hwang, D.; Walters, M.; Johnson, R.; Amin, E.; Finzel, B.
Anthrax toxin lethal factor domain 3 is highly mobile and responsive to ligand binding
Acta Crystallogr. Sect. D
70
2813-2822
2014
Bacillus anthracis (P15917)
Moayeri, M.; Crown, D.; Jiao, G.; Kim, S.; Johnson, A.; Leysath, C.; Leppla, S.
Small-molecule inhibitors of lethal factor protease activity protect against anthrax infection
Antimicrob. Agents Chemother.
57
4139-4145
2013
Bacillus anthracis (P15917), Bacillus anthracis
Vourtsis, D.; Chasapis, C.; Pairas, G.; Bentrop, D.; Spyroulias, G.
NMR conformational properties of an Anthrax lethal factor domain studied by multiple amino acid-selective labeling
Biochem. Biophys. Res. Commun.
450
335-340
2014
Bacillus anthracis (P15917)
Montpellier, L.; Siemann, S.
Effect of pH on the catalytic function and zinc content of native and immobilized anthrax lethal factor
FEBS Lett.
587
317-321
2013
Bacillus anthracis (P15917)
Ouyang, W.; Torigoe, C.; Fang, H.; Xie, T.; Frucht, D.
Anthrax lethal toxin inhibits translation of hypoxia-inducible factor 1alpha and causes decreased tolerance to hypoxic stress
J. Biol. Chem.
289
4180-4190
2014
Bacillus anthracis
Antonelli, A.; Zhang, Y.; Golub, L.; Johnson, F.; Simon, S.
Inhibition of anthrax lethal factor by curcumin and chemically modified curcumin derivatives
J. Enzyme Inhib. Med. Chem.
29
663-669
2014
Bacillus anthracis
Lo, S.; Säbel, C.; Webb, M.; Walsby, C.; Siemann, S.
High metal substitution tolerance of anthrax lethal factor and characterization of its active copper-substituted analogue
J. Inorg. Biochem.
140
12-22
2014
Bacillus anthracis (P15917)
Liao, H.; Liu, H.; Chen, W.; Ho, Y.
Structure-based pharmacophore modeling and virtual screening to identify novel inhibitors for anthrax lethal factor
Med. Chem. Res.
23
3725-3732
2014
Bacillus anthracis (P15917)
-
Sun, C.; Fang, H.; Xie, T.; Auth, R.; Patel, N.; Murray, P.; Snoy, P.; Frucht, D.
Anthrax lethal toxin disrupts intestinal barrier function and causes systemic infections with enteric bacteria
PLoS ONE
7
e33583
2012
Bacillus anthracis (P15917), Bacillus anthracis
Levinsohn, J.; Newman, Z.; Hellmich, K.; Fattah, R.; Getz, M.; Liu, S.; Sastalla, I.; Leppla, S.; Moayeri, M.
Anthrax lethal factor cleavage of Nlrp1 is required for activation of the inflammasome
PLoS Pathog.
8
e1002638
2012
Bacillus anthracis (P15917)
Kassab, E.; Darwish, M.; Timsah, Z.; Liu, S.; Leppla, S.; Frankel, A.; Abi-Habib, R.
Cytotoxicity of anthrax lethal toxin to human acute myeloid leukemia cells is nonapoptotic and dependent on extracellular signal-regulated kinase 1/2 activity
Transl. Oncol.
6
25-32
2013
Bacillus anthracis (P15917)
Lo, S.Y.; Saebel, C.E.; Mapletoft, J.P.J.; Siemann, S.
Influence of chemical denaturants on the activity, fold and zinc status of anthrax lethal factor
Biochem. Biophys. Rep.
1
68-77
2015
Bacillus anthracis (P15917)
Goldberg, A.B.; Turk, B.E.
Inhibitors of the metalloproteinase anthrax lethal factor
Curr. Top. Med. Chem.
16
2350-2358
2016
Bacillus anthracis (P15917), Bacillus anthracis
Maize, K.M.; Kurbanov, E.K.; Johnson, R.L.; Amin, E.A.; Finzel, B.C.
Ligand-induced expansion of the S1 site in the anthrax toxin lethal factor
FEBS Lett.
589
3836-3841
2015
Bacillus anthracis (P15917), Bacillus anthracis
Zhang, W.W.; Wang, X.; Xie, P.; Yuan, S.T.; Liu, Q.H.
Anthrax lethal toxin suppresses high glucose induced VEGF over secretion through a post-translational mechanism
Int. J. Ophthalmol.
8
453-458
2015
Bacillus anthracis (P15917)
Ma, P.; Cardenas, A.E.; Chaudhari, M.I.; Elber, R.; Rempe, S.B.
The impact of protonation on early translocation of anthrax lethal factor kinetics from molecular dynamics simulations and milestoning theory
J. Am. Chem. Soc.
139
14837-14840
2017
Bacillus anthracis (P15917)
Ouyang, W.; Guo, P.; Fang, H.; Frucht, D.M.
Anthrax lethal toxin rapidly reduces c-Jun levels by inhibiting c-Jun gene transcription and promoting c-Jun protein degradation
J. Biol. Chem.
292
17919-17927
2017
Bacillus anthracis (P15917), Bacillus anthracis
Goldberg, A.B.; Cho, E.; Miller, C.J.; Lou, H.J.; Turk, B.E.
Identification of a substrate-selective exosite within the metalloproteinase anthrax lethal factor
J. Biol. Chem.
292
814-825
2017
Bacillus anthracis (P15917), Bacillus anthracis
Krantz, B.
Anthrax lethal toxin co-complexes are stabilized by contacts between adjacent lethal factors
J. Gen. Physiol.
148
1966-1970
2016
Bacillus anthracis (P15917)
Young, C.J.; Richard, K.; Beruar, A.; Lo, S.Y.; Siemann, S.
An investigation of the pH dependence of copper-substituted anthrax lethal factor and its mechanistic implications
J. Inorg. Biochem.
182
1-8
2018
Bacillus anthracis (P15917)
html completed
