3.4.24.83: anthrax lethal factor endopeptidase

This is an abbreviated version!
For detailed information about anthrax lethal factor endopeptidase, go to the full flat file.

Word Map on EC 3.4.24.83

3.4.24.83

edema

spore

intoxication

endosomal

exotoxin

metalloprotease

inhalation

inflammasome

endocytosis

toxin-induced

anti-pa

heptameric

caspase-1

sterne

furin

mapkks

lt-induced

tripartite

diphtheria

toxin-mediated

spore-forming

pyroptosis

toxemia

ring-shaped

receptor-bound

toxin-neutralizing

zinc-dependent

molecular biology

cytolysis

pa-binding

medicine

mkk

bioterrorism

diagnostics

toxin-sensitive

synthesis

postexposure

cell-binding

Reaction

Preferred amino acids around the cleavage site can be denoted BBBBxHx-/-H, in which B denotes Arg or Lys, H denotes a hydrophobic amino acid, and x is any amino acid. The only known protein substrates are mitogen-activated protein (MAP) kinase kinases =

Synonyms

anthrax lethal factor, anthrax lethal factor protease, anthrax lethal toxin, anthrax LF, anthrax toxin lethal factor, Bacillus anthracis lethal toxin, lethal factor, lethal factor of anthrax toxin, lethal toxin, LeTx, LF, LTx

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.24 Metalloendopeptidases

3.4.24.83 anthrax lethal factor endopeptidase

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Results	in table
4	Activating Compound
21	AA Sequence
31	Application
2	CAS Registry Number
14	Cloned(Commentary)
6	Crystallization (Commentary)
16	General Information
109	IC50 Value
173	Inhibitors
8	kcat/KM [mM/s]
72	Ki Value [mM]
13	KM Value [mM]
5	Localization
28	Metals/Ions
7	Molecular Weight [Da]
36	Natural Substrates/ Products (Substrates)
101	Organism
35	PDB ID
3	pH Optimum
4	pH Range
1	pH Stability
29	Protein Variants
7	Purification (Commentary)
5	Reaction
3	Reaction Type
100	Reference
1	Source Tissue
2	Specific Activity [micromol/min/mg]
1	Storage Stability
110	Substrates and Products (Substrate)
6	Subunits
81	Synonyms
2	Temperature Optimum [°C]
8	Turnover Number [1/s]

KM Value

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KM Value on EC 3.4.24.83 - anthrax lethal factor endopeptidase

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0.0023 - 0.0042

acetyl-Gly-Tyr-beta-Ala-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Val-Leu-Arg-4-nitroanilide

2 entries

0.0016 - 0.0019

acetyl-Gly-Tyr-beta-Ala-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Val-Leu-Arg-7-amido-4-methylcoumarin

2 entries

0.073

acetyl-GYbetaARRRRRRRRVLR-4-nitroanilide

Bacillus anthracis

P15917

pH 7.4, 22°C, apoprotein reconstituted in presence of Zn2+

734422

0.0018

AcG-Y-betaA-R-R-R-A-R-R-R-R-V-L-R-4-nitroanilide

Bacillus anthracis

638968

0.03

AcM-L-A-R-R-R-P-V-L-P-4-nitroanilide

Bacillus anthracis

638968

0.082

AcR-R-R-R-V-L-R-4-methylcoumarin-7-amide

Bacillus anthracis

638968

0.0095

AcR-R-R-R-V-L-R-4-nitroanilide

Bacillus anthracis

638968

0.0023 - 0.042

fluorescein-QRRKKVYPYPME

3 entries

0.0086

fluorescence resonance energy transfer peptide MAPKKide

Bacillus anthracis

in 20 mM HEPES, pH 7.4, at 25°C

679744