3.4.24.74: fragilysin
This is an abbreviated version!
For detailed information about fragilysin, go to the full flat file.
Word Map on EC 3.4.24.74
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3.4.24.74
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staphylococcal
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aureus
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enterotoxigenic
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heat-labile
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superantigens
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heat-stable
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cholera
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diarrhea
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clostridium
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perfringens
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lymphocyte
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t-cells
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vaccine
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poisoning
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mucosal
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milk
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vibrio
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ifn-gamma
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outbreak
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serotype
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sta
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serogroups
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anergy
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foodborne
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enteropathogenic
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ganglioside
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gm1
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hydrophila
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exotoxin
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methicillin-resistant
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hemolysin
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cytotoxin
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ileal
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toxigenic
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stool
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agglutination
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emetic
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enterocolitica
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shiga
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toxin-producing
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retail
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coagulase
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rotavirus
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b-subunits
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medicine
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methicillin
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holotoxin
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antitoxin
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toxoid
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pyrogen
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anti-cd3
- 3.4.24.74
-
staphylococcal
- aureus
- enterotoxigenic
-
heat-labile
-
superantigens
-
heat-stable
- cholera
-
diarrhea
- clostridium
- perfringens
- lymphocyte
- t-cells
- vaccine
- poisoning
- mucosal
- milk
- vibrio
- ifn-gamma
-
outbreak
-
serotype
- sta
-
serogroups
-
anergy
- foodborne
-
enteropathogenic
- ganglioside
- gm1
- hydrophila
-
exotoxin
-
methicillin-resistant
- hemolysin
-
cytotoxin
- ileal
-
toxigenic
-
stool
-
agglutination
-
emetic
- enterocolitica
-
shiga
-
toxin-producing
-
retail
- coagulase
- rotavirus
-
b-subunits
- medicine
- methicillin
-
holotoxin
- antitoxin
- toxoid
-
pyrogen
-
anti-cd3
Reaction
Broad proteolytic specificity, bonds hydrolysed including -Gly-/-Leu-, -Met-/-Leu-, -Phe-/-Leu-, -Cys-/-Leu-, Leu-/-Gly =
Synonyms
B. fragilis enterotoxin, Baceroides fragilis enterotoxin, Bacillus fragilis toxin, Bacteroides fragilis enterotoxin, Bacteroides fragilis enterotoxin-2, Bacteroides fragilis toxin, BFT, BFT-1, BFT-2, BFT-3, BFT2, Enterotoxin, FRA3, fragilysin-2, fragilysin-3, Korea-BFT, More, toxin-2
ECTree
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General Information
General Information on EC 3.4.24.74 - fragilysin
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physiological function
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role of BFT in human host beta-defensin 2 induction from intestinal epithelial cells, HT-29 and Caco-2, requiring the presence of NF-kappaB binding sites. Also binding of NF-kappaB to the hBD-2 promoter is required for the induction of the hBD-2 gene in BFT-stimulated intestinal epithelial cells, while AP-1 is not involved, regulation, overview. Heat-labile enterotoxin BFT plays an essential role in host mucosal inflammation
physiological function
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recombinant Bacteroides fragilis toxin (BFT, 5 nM) upregulates spermine oxidase in human colonic epithelial cell lines HT-29/c1 and T-84, resulting in spermine oxidase-dependent generation of reactive oxygen species and induction of gamma-H2A.x, a marker of DNA damage. BFT exposure did not increase spermidine/spermine-N1-acetyltransferase or N1-acetylpolyamine oxidase expression
physiological function
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the enzyme plays an essential role in mucosal inflammation and affects the expression of ICAM-1 and monocytic adhesion to endothelial cells. Stimulation of HUVECs and rat aortic endothelial cells with Bacteroides fragilis enterotoxin results in the induction of ICAM-1 expression
physiological function
enterotoxin plays an essential role in mucosal inflammation and upregulates lipocalin-2 expression in intestinal epithelial cells through the activation of mitogen-activated protein kinases and the activator protein-1 signaling pathway
physiological function
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the enzyme can destroy the tight junctions in intestinal epithelium by cleaving E-cadherin, resulting in release of beta-catenin and loss of tight junctions. Intestinal epithelial cells exposed to bacteroides fragilis enterotoxin regulate nuclear factor-kappaB activation and inflammatory responses through beta-catenin expression
physiological function
the enzyme contributes to anaerobic sepsis. The colonic epithelial barrier is an important target of the enzyme
physiological function
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the enzyme stimulates intestinal secretion, resulting in epithelial damage and necrosis. The enzyme is a virulence factor of enterotoxigenic Bacteroides fragilis that accompanies blood stream infections. Outer surface-exposed enzyme causes epithelial cell contact disruption
physiological function
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recombinant Bacteroides fragilis toxin (BFT, 5 nM) upregulates spermine oxidase in human colonic epithelial cell lines HT-29/c1 and T-84, resulting in spermine oxidase-dependent generation of reactive oxygen species and induction of gamma-H2A.x, a marker of DNA damage. BFT exposure did not increase spermidine/spermine-N1-acetyltransferase or N1-acetylpolyamine oxidase expression
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