3.4.24.74: fragilysin
This is an abbreviated version!
For detailed information about fragilysin, go to the full flat file.
Word Map on EC 3.4.24.74
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3.4.24.74
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staphylococcal
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aureus
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enterotoxigenic
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heat-labile
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superantigens
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heat-stable
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cholera
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diarrhea
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clostridium
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perfringens
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lymphocyte
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t-cells
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vaccine
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poisoning
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mucosal
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milk
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vibrio
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ifn-gamma
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outbreak
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serotype
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sta
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serogroups
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anergy
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foodborne
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enteropathogenic
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ganglioside
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gm1
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hydrophila
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exotoxin
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methicillin-resistant
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hemolysin
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cytotoxin
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ileal
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toxigenic
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stool
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agglutination
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emetic
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enterocolitica
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shiga
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toxin-producing
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retail
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coagulase
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rotavirus
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b-subunits
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medicine
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methicillin
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holotoxin
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antitoxin
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toxoid
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pyrogen
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anti-cd3
- 3.4.24.74
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staphylococcal
- aureus
- enterotoxigenic
-
heat-labile
-
superantigens
-
heat-stable
- cholera
-
diarrhea
- clostridium
- perfringens
- lymphocyte
- t-cells
- vaccine
- poisoning
- mucosal
- milk
- vibrio
- ifn-gamma
-
outbreak
-
serotype
- sta
-
serogroups
-
anergy
- foodborne
-
enteropathogenic
- ganglioside
- gm1
- hydrophila
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exotoxin
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methicillin-resistant
- hemolysin
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cytotoxin
- ileal
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toxigenic
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stool
-
agglutination
-
emetic
- enterocolitica
-
shiga
-
toxin-producing
-
retail
- coagulase
- rotavirus
-
b-subunits
- medicine
- methicillin
-
holotoxin
- antitoxin
- toxoid
-
pyrogen
-
anti-cd3
Reaction
Broad proteolytic specificity, bonds hydrolysed including -Gly-/-Leu-, -Met-/-Leu-, -Phe-/-Leu-, -Cys-/-Leu-, Leu-/-Gly =
Synonyms
B. fragilis enterotoxin, Baceroides fragilis enterotoxin, Bacillus fragilis toxin, Bacteroides fragilis enterotoxin, Bacteroides fragilis enterotoxin-2, Bacteroides fragilis toxin, BFT, BFT-1, BFT-2, BFT-3, BFT2, Enterotoxin, FRA3, fragilysin-2, fragilysin-3, Korea-BFT, More, toxin-2
ECTree
3.4.24.74 fragilysinAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 3.4.24.74 - fragilysin
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
E-cadherin + H2O
?
cleavage of the zonula adherens protein
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?
E-cadherin + H2O
?
the enzyme hydrolyzes the extracellular domain of several protein substrate, e.g. of E-cadherin to interrupt the intercellular adhesion increasing the permeability of the epithelium, and causing intracellular redistribution of actin with morphologic changes and release of beta-catenin
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-
?
E-cadherin + H2O
?
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the enzyme cleaves the extracellular domain of E-cadherin. Its cleavage then releases beta-catenin associated with the cytoplasmic domain of E-cadherin
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-
?
Proteins + H2O
?
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the enzyme increases the paracellular permeability of the intestinal epithelium by digestion of the intestinal light junctions and cell-to-cell contacts, it does not disrupt cell membranes
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-
?
Proteins + H2O
?
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proteolytic action on the actin of the cytoskeleton
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?
Proteins + H2O
?
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active in lamb, rabbit, rat ileum and colon, it causes the production of fluids and hemorrhage, it increases the levels of Na+ and Cl- in intestinal loops due to tissue damage
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-
?
additional information
?
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the cytopathic effect of the enzyme is only seen in cells that can form tight junction and polarized monolayers, the enzyme affects the barrier function of the epithelium and decreases the transpithelial electrical resistance of monolayers, overview, the enzyme stimulates the recruitment of polymorphs to the lamina propria and seceretion of interleukin-8, epithelial neutrophil-activating peptide-78, and growth-related oncogene-alpha from colonocytes, overview
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-
?
additional information
?
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the cytopathic effect of the enzyme is only seen in cells that can form tight junction and polarized monolayers, the enzyme affects the barrier function of the epithelium and decreases the transpithelial electrical resistance of monolayers, overview, the enzyme stimulates the recruitment of polymorphs to the lamina propria and seceretion of interleukin-8, epithelial neutrophil-activating peptide-78, and growth-related oncogene-alpha from colonocytes, overview
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-
?
additional information
?
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the cytopathic effect of the enzyme is only seen in cells that can form tight junction and polarized monolayers, the enzyme affects the barrier function of the epithelium and decreases the transpithelial electrical resistance of monolayers, overview, the enzyme stimulates the recruitment of polymorphs to the lamina propria and seceretion of interleukin-8, epithelial neutrophil-activating peptide-78, and growth-related oncogene-alpha from colonocytes, overview
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-
?
additional information
?
-
-
the cytopathic effect of the enzyme is only seen in cells that can form tight junction and polarized monolayers, the enzyme affects the barrier function of the epithelium and decreases the transpithelial electrical resistance of monolayers, overview, the enzyme stimulates the recruitment of polymorphs to the lamina propria and seceretion of interleukin-8, epithelial neutrophil-activating peptide-78, and growth-related oncogene-alpha from colonocytes, overview
-
-
?
additional information
?
-
the cytopathic effect of the enzyme is only seen in cells that can form tight junction and polarized monolayers, the enzyme affects the barrier function of the epithelium and decreases the transpithelial electrical resistance of monolayers, overview, the enzyme stimulates the recruitment of polymorphs to the lamina propria and secretion of interleukin-8, epithelial neutrophil-activating peptide-78, and growth-related oncogene-alpha from colonocytes, overview
-
-
?
additional information
?
-
the cytopathic effect of the enzyme is only seen in cells that can form tight junction and polarized monolayers, the enzyme affects the barrier function of the epithelium and decreases the transpithelial electrical resistance of monolayers, overview, the enzyme stimulates the recruitment of polymorphs to the lamina propria and secretion of interleukin-8, epithelial neutrophil-activating peptide-78, and growth-related oncogene-alpha from colonocytes, overview
-
-
?
additional information
?
-
the cytopathic effect of the enzyme is only seen in cells that can form tight junction and polarized monolayers, the enzyme affects the barrier function of the epithelium and decreases the transpithelial electrical resistance of monolayers, overview, the enzyme stimulates the recruitment of polymorphs to the lamina propria and secretion of interleukin-8, epithelial neutrophil-activating peptide-78, and growth-related oncogene-alpha from colonocytes, overview
-
-
?
additional information
?
-
-
the cytopathic effect of the enzyme is only seen in cells that can form tight junction and polarized monolayers, the enzyme affects the barrier function of the epithelium and decreases the transpithelial electrical resistance of monolayers, overview, the enzyme stimulates the recruitment of polymorphs to the lamina propria and secretion of interleukin-8, epithelial neutrophil-activating peptide-78, and growth-related oncogene-alpha from colonocytes, overview
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-
?
additional information
?
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the enterotoxin has cytotoxic activity, however strains isolated from stool samples of calves with diarrhea contain the gene bft, but do not show cytotoxic activity against HT29 cells, overview
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?
