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Literature summary for 3.4.24.74 extracted from

  • Goodwin, A.C.; Destefano Shields, C.E.; Wu, S.; Huso, D.L.; Wu, X.; Murray-Stewart, T.R.; Hacker-Prietz, A.; Rabizadeh, S.; Woster, P.M.; Sears, C.L.; Casero, R.A.
    Polyamine catabolism contributes to enterotoxigenic Bacteroides fragilis-induced colon tumorigenesis (2011), Proc. Natl. Acad. Sci. USA, 108, 15354-15359.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
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 Bacteroides fragilis

Organism

Organism UniProt Comment Textmining
Bacteroides fragilis
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-
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Bacteroides fragilis 86-5443-2-2
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-
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Purification (Commentary)

Purification (Comment) Organism
-
 Bacteroides fragilis

Synonyms

Synonyms Comment Organism
Bacteroides fragilis toxin
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 Bacteroides fragilis
BFT
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 Bacteroides fragilis

General Information

General Information Comment Organism
physiological function recombinant Bacteroides fragilis toxin (BFT, 5 nM) upregulates spermine oxidase in human colonic epithelial cell lines HT-29/c1 and T-84, resulting in spermine oxidase-dependent generation of reactive oxygen species and induction of gamma-H2A.x, a marker of DNA damage. BFT exposure did not increase spermidine/spermine-N1-acetyltransferase or N1-acetylpolyamine oxidase expression Bacteroides fragilis