3.4.24.68: tentoxilysin
This is an abbreviated version!
For detailed information about tentoxilysin, go to the full flat file.
Word Map on EC 3.4.24.68
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3.4.24.68
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synaptic
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botulinum
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toxoid
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nerve
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epitope
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neurotransmitter
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exocytosis
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spinal
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ganglioside
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tetany
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cord
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clostridial
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retrograde
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presynaptic
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synaptobrevin
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snare
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antitoxin
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epilepsy
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neuromuscular
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transmitter
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synapses
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diphtheria
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excitatory
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bonts
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vesicle-associated
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snap-25
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syntaxin
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postsynaptic
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paralysis
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vamp
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motoneuron
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synaptosomes
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gt1b
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booster
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n-ethylmaleimide-sensitive
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toxin-induced
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v-snares
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intrahippocampal
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transsynaptic
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phrenic
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neuroparalytic
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holotoxin
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k+-evoked
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neurospecific
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electrograph
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monosynaptic
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circumsporozoite
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synaptosome-associated
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medicine
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interictal
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3hnoradrenaline
- 3.4.24.68
- synaptic
- botulinum
- toxoid
- nerve
- epitope
-
neurotransmitter
-
exocytosis
- spinal
- ganglioside
- tetany
- cord
-
clostridial
-
retrograde
-
presynaptic
- synaptobrevin
- snare
- antitoxin
- epilepsy
- neuromuscular
-
transmitter
- synapses
- diphtheria
-
excitatory
-
bonts
-
vesicle-associated
- snap-25
- syntaxin
-
postsynaptic
- paralysis
- vamp
- motoneuron
-
synaptosomes
- gt1b
-
booster
-
n-ethylmaleimide-sensitive
-
toxin-induced
-
v-snares
-
intrahippocampal
-
transsynaptic
-
phrenic
-
neuroparalytic
-
holotoxin
-
k+-evoked
-
neurospecific
-
electrograph
-
monosynaptic
-
circumsporozoite
-
synaptosome-associated
- medicine
-
interictal
-
3hnoradrenaline
Reaction
Hydrolysis of -Gln76-/-Phe- bond in synaptobrevin (also known as neuronal vesicle-associated membrane protein, VAMP) =
Synonyms
TeNT, TeNT-Hc, TeNT-LC protein, Tentoxylysin, tetanospasmin, Tetanus neurotoxin, tetanus toxin, TetX
ECTree
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General Information
General Information on EC 3.4.24.68 - tentoxilysin
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malfunction
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TeNT cleaves vesicle-associated membrane protein-2, thereby inhibiting neurotransmitter release in the central nervous system to elicit spastic paralysis
metabolism
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the enzyme cleaves a neuronal soluble N-ethylmaleimide-sensitive attachment receptor protein, leading to the blockade of inhibitory neurotransmitter release and subsequent generalized muscular spasm
physiological function
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cleavage of synaptobrevin results in inhibition of release of neurotransmitters glycine and gamma-amino butyric acid from inhibitory interneurons causing spastic paralysis
physiological function
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the enzyme is the most important virulence factor that plays a key role in the pathogenicity of tetanus
physiological function
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the enzyme undergoes binding to specific components of the basal membrane at the neuromuscular junction, is endocytosed into motor neurons and sorted to axonal signaling endosomes. Following this, the enzyme is transported to the soma of motor neurons located in the spinal cord or brainstem, and then transcytosed to inhibitory interneurons, where it blocks synaptic transmission. Enzyme-induced impairment of inhibitory input leads to hyperactivity of motor neurons, causing spastic paralysis