3.4.24.22: stromelysin 2
This is an abbreviated version!
For detailed information about stromelysin 2, go to the full flat file.
Word Map on EC 3.4.24.22
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3.4.24.22
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metalloproteinases
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mmp-9
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collagen
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metastasis
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timps
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endothelial
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stromelysin-1
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gelatinase
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cartilage
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basement
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keratinocytes
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zymography
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matrilysin
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diagnostics
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collagenase-1
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collagenolytic
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medicine
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sdc1
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metalloelastase
- 3.4.24.22
- metalloproteinases
- mmp-9
- collagen
- metastasis
- timps
- endothelial
- stromelysin-1
- gelatinase
- cartilage
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basement
- keratinocytes
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zymography
- matrilysin
- diagnostics
- collagenase-1
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collagenolytic
- medicine
- sdc1
- metalloelastase
Reaction
Similar to stromelysin 1, but action on collagen types III, IV and V is weak =
Synonyms
Matrix metalloproteinase 10, Matrix metalloproteinase-10, MMP-10, MMP10, More, Proteoglycanase 2, ST-2, stromelysin 2, stromelysin-2, Transformation-associated protein 34A, Transin 2, Transins, 2
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General Information
General Information on EC 3.4.24.22 - stromelysin 2
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evolution
malfunction
metabolism
physiological function
additional information
despite their similar substrate specificities, the stromelysins show differential patterns of transcriptional regulation and tissue distribution that hint at distinct physiological functions in processes such as skeletal development, wound healing, and vascular remodeling
evolution
sequence comparisons of MMP-3 (EC 3.4.22.17) and MMP-10, high similarity
evolution
Mus musculus C57BL/KsOlaHsd-Db/+
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sequence comparisons of MMP-3 (EC 3.4.22.17) and MMP-10, high similarity
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association between MMP-9, MMP-10, TIMP-1, and MMP-9/TIMP-1 ratios and parameters of sepsis severity, overview
malfunction
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MMP-10 may be important in the initial stages of squamous cell cancer progression and induced in the stroma relating to the general host-response reaction to skin cancer. Contribution of MMP-10 to squamous cell cancer development in the FVB/NTg(KRT5-Nfkbia)3Rto mouse line, overview
malfunction
MMP-10 plays a critical role in VEGF-induced angiogenesis, overview
malfunction
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ectopic overexpression of MMP-10 promotes the invasion of head and neck squamous cell carcinoma cells, and knockdown of MMP-10 suppressed the invasion of head and neck squamous cell carcinoma cells
malfunction
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Mmp10 knockout mice show a significant reduction in lung tumor number and size after urethane exposure or genetic activation of oncogenic Kras
malfunction
RNAi-mediated knockdown of Mmp10 leads to a loss of stem cell marker gene expression and inhibition of oncosphere growth, clonal expansion, and transformed growth in vitro. Enzyme Mmp10-deficient cultures show a severe defect in tumor initiation
malfunction
in acute Pseudomonas aeruginosa infection, 50% of Mmp10-/- mice die and all show sustained weight loss (morbidity), but lethality and morbidity in Mmp10-/- mice are not due to impaired bacterial clearance. Mmp10-/- mice die due to altered or excessive inflammation
malfunction
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oropharyngeal aspiration of long multiwalled carbon nanotubes (MWCNTs) (0.08 mg/mouse) by wild-type mice induces expression of Mmp10 mRNA, which is accompanied by a robust inflammatory response characterized by elevated expression of Tnfa, Il6, and Il1b. In Mmp10-/- mice, absence of MMP-10 leads to impaired pulmonary clearance of MWCNTs and reduced macrophage cell survival. Exposure of wild-type bone marrow-derived macrophages (BMDMs) and alveolar macrophages to MWCNTs caused a rapid, dose-dependent upregulation of Mmp10 mRNA expression, which was accompanied by expression of pro-inflammatory products (Il6 and Il1b). These products were further enhanced in Mmp10-/- macrophages, resulting in increased caspase-3-dependent cell death compared with wild-type cells. Absence of Mmp-10 confers sensitivity to apoptosis in BMDMs without an increase in endocytosis
malfunction
the gene for matrix metalloproteinase 10 is the most significantly upregulated gene in patients with systemic sclerosis (SSc)-associated pulmonary hypertension (PH). Lack of effect of MMP10 blockade on the development and severity of pulmonary fibrosis but reversal of PH in Fra-2-Tg mice, lung expression patterns. Substantial increase in the levels of MMP10 in the remodeled vessels of Fra-2-Tg mice, efficacy of MMP10 inhibition on the development of PH in Fra-2-Tg mice. MMP10 inhibition acts through the regulation of cell proliferation and apoptosis to alleviate vascular remodeling and the signs of PH
malfunction
the gene for matrix metalloproteinase 10 is the most significantly upregulated gene in patients with systemic sclerosis (SSc)-associated pulmonary hypertension (PH). MMP10 inhibition acts through the regulation of cell proliferation and apoptosis to alleviate vascular remodeling and the signs of PH
malfunction
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MMP-10 may be important in the initial stages of squamous cell cancer progression and induced in the stroma relating to the general host-response reaction to skin cancer. Contribution of MMP-10 to squamous cell cancer development in the FVB/NTg(KRT5-Nfkbia)3Rto mouse line, overview
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malfunction
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RNAi-mediated knockdown of Mmp10 leads to a loss of stem cell marker gene expression and inhibition of oncosphere growth, clonal expansion, and transformed growth in vitro. Enzyme Mmp10-deficient cultures show a severe defect in tumor initiation
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malfunction
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in acute Pseudomonas aeruginosa infection, 50% of Mmp10-/- mice die and all show sustained weight loss (morbidity), but lethality and morbidity in Mmp10-/- mice are not due to impaired bacterial clearance. Mmp10-/- mice die due to altered or excessive inflammation
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MMP-10 is a potent activator of a number of MMP pro-enzymes, including pro-MMP-1, -7, -8, -9 and -13
metabolism
fibroblast secretome cleavage analysis, analysis of the MMP10 substrate degradome, overview
metabolism
matrix metalloproteinases (MMPs) play central roles in vertebrate tissue development, remodeling, and repair. The endogenous tissue inhibitors of metalloproteinases (TIMPs) regulate proteolytic activity by binding tightly to the MMP active site. While each of the four TIMPs can inhibit most MMPs, binding data reveal tremendous heterogeneity in affinities of different TIMP/MMP pairs
metabolism
macrophage MMP10 promotes the ability of M2 macrophages to clear scar tissues in normal skin wounds by controlling the expression of collagenolytic MMPs, particularly MMP13
metabolism
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fibroblast secretome cleavage analysis, analysis of the MMP10 substrate degradome, overview
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metabolism
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macrophage MMP10 promotes the ability of M2 macrophages to clear scar tissues in normal skin wounds by controlling the expression of collagenolytic MMPs, particularly MMP13
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matrix metalloproteinases play a role in infectious diseases through extracellular matrix degradation, which favors the migration of immune cells from the bloodstream to sites of inflammation
physiological function
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MMP-10 may be important in the initial stages of squamous cell cancer progression and induced in the stroma relating to the general host-response reaction to skin cancer. MMP-10 is expressed in Bowen's disease
physiological function
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role for MMP-10 in the TGF-beta- and EGF-stimulated collagen remodelling process
physiological function
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MMP-10 efficiently reduces infarct size in experimental stroke by enhancing fibrinolysis via a thrombin-activatable fibrinolysis inhibitormediated mechanism
physiological function
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MMP-10 plays an important role in the invasion and metastasis of head and neck squamous cell carcinoma
physiological function
role for the enzyme in the maintenance, tumorigenicity, and proliferation of mouse lung cancer stem-like cells, overview
physiological function
the enzyme functions in skeletal development, wound healing, and vascular remodeling. It is also implicated in lung tumorigenesis and tumor progression. Regulation of enzyme MMP-10 by tissue inhibitors of metalloproteinases
physiological function
the enzyme performs ectodomain shedding of platelet-derived growth factor receptor alpha as well as sequential processing of type I collagen
physiological function
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the enzyme plays an important role in esophageal squamous cell carcinoma progression in the early stage
physiological function
MMP10 regulates macrophage activation. macrophage MMP10 serves a beneficial function in response to acute Pseudomonas aeruginosa infection. Whereas wild-type mice survive infection with minimal morbidity, while 50% of Mmp10-/- mice die and all show sustained weight loss (morbidity). MMP10 serves a beneficial role in response to acute infection by moderating the pro-inflammatory response of resident and infiltrating macrophages. MMP10 serves a protective role in acute infection by moderating the pro-inflammatory activity of macrophages
physiological function
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stromelysin-2 (MMP-10) has roles in modulating macrophage activation and function. MMP-10 facilitates clearance and moderates inflammation and cell death following lung exposure to long multiwalled carbon nanotubes. Multiwalled carbon nanotubes (MWCNTs) are nanomaterials composed of multiple layers of graphene cylinders with unique properties that make them valuable for a number of industries that possibly initiate pathology similar to that of asbestos. MMP-10 protects against MWCNT-associated losses of macrophages via apoptosis, and MMP-10 facilitates clearance of MWCNTs, overview
physiological function
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the enzyme performs ectodomain shedding of platelet-derived growth factor receptor alpha as well as sequential processing of type I collagen
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physiological function
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role for the enzyme in the maintenance, tumorigenicity, and proliferation of mouse lung cancer stem-like cells, overview
-
physiological function
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MMP10 regulates macrophage activation. macrophage MMP10 serves a beneficial function in response to acute Pseudomonas aeruginosa infection. Whereas wild-type mice survive infection with minimal morbidity, while 50% of Mmp10-/- mice die and all show sustained weight loss (morbidity). MMP10 serves a beneficial role in response to acute infection by moderating the pro-inflammatory response of resident and infiltrating macrophages. MMP10 serves a protective role in acute infection by moderating the pro-inflammatory activity of macrophages
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gene expression of interleukin-1, nerve growth factor, and tumour necrosis factor-alpha does not correlate with matrix metalloproteinase-10 in human nucleus pulposus, but expression of substance P does correlate with MMP-10 expression, overview
additional information
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interleukin-10 positively correlates with inhibitor TIMP-1 and MMP-10 in sepsis patients
additional information
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MMP-10 is not associated with keratinocyte apoptosis or atypia
additional information
transcriptional regulation of MMP-10 by Ets transcription factors
additional information
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transcriptional regulation of MMP-10 by Ets transcription factors
additional information
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overexpression of matrix metalloproteinase 10 is associated with poor survival in patients with early stage of esophageal squamous cell carcinoma. Although the overexpression of MMP10 is not significantly associated with disease-specific survival rate for all tested esophageal squamous cell carcinomas, it is significantly associated with poorer disease-specific survival in early stage of esophageal squamous cell carcinomas
additional information
strong positive correlation between tumor Mmp10 expression and metastatic behavior in many human tumor types
additional information
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strong positive correlation between tumor Mmp10 expression and metastatic behavior in many human tumor types
additional information
the active site of the domain possesses the conserved zinc-binding motif HEXXHXXGXXH, in which the imidazole side chains of His217, His221, and His227 coordinate the catalytic zinc ion, and Glu218 is positioned to function as a general acid/base in the hydrolysis reaction
additional information
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the active site of the domain possesses the conserved zinc-binding motif HEXXHXXGXXH, in which the imidazole side chains of His217, His221, and His227 coordinate the catalytic zinc ion, and Glu218 is positioned to function as a general acid/base in the hydrolysis reaction
additional information
biologic functions and differentially expressed genes identified by microarray analysis in patients with SSc-associated PH as compared to SSc patients without PH and healthy controls, overview
additional information
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biologic functions and differentially expressed genes identified by microarray analysis in patients with SSc-associated PH as compared to SSc patients without PH and healthy controls, overview
additional information
peptide specific affinity-purified antibodies. Antibody cross-reactivity due to the extreme similarity between MMP-3 (EC 3.4.24.17) and MMP-10 proteins, lab-made antibodies for MMP-10 (D248/6 or IW13)
additional information
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peptide specific affinity-purified antibodies. Antibody cross-reactivity due to the extreme similarity between MMP-3 (EC 3.4.24.17) and MMP-10 proteins, lab-made antibodies for MMP-10 (D248/6 or IW13)
additional information
Mus musculus C57BL/KsOlaHsd-Db/+
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peptide specific affinity-purified antibodies. Antibody cross-reactivity due to the extreme similarity between MMP-3 (EC 3.4.24.17) and MMP-10 proteins, lab-made antibodies for MMP-10 (D248/6 or IW13)
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additional information
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MMP-10 is not associated with keratinocyte apoptosis or atypia
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additional information
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strong positive correlation between tumor Mmp10 expression and metastatic behavior in many human tumor types
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