3.4.24.22: stromelysin 2

This is an abbreviated version!
For detailed information about stromelysin 2, go to the full flat file.

Word Map on EC 3.4.24.22

3.4.24.22

metalloproteinases

mmp-9

collagen

metastasis

timps

endothelial

stromelysin-1

gelatinase

cartilage

basement

keratinocytes

zymography

matrilysin

diagnostics

collagenase-1

collagenolytic

medicine

sdc1

metalloelastase

Reaction

Similar to stromelysin 1, but action on collagen types III, IV and V is weak =

Synonyms

Matrix metalloproteinase 10, Matrix metalloproteinase-10, MMP-10, MMP10, More, Proteoglycanase 2, ST-2, stromelysin 2, stromelysin-2, Transformation-associated protein 34A, Transin 2, Transins, 2

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.24 Metalloendopeptidases

3.4.24.22 stromelysin 2

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Results	in table
1	Activating Compound
8	AA Sequence
7	Application
1	CAS Registry Number
11	Cloned(Commentary)
3	Crystallization (Commentary)
1174	Disease/ Diagnostics
14	Expression
50	General Information
22	Inhibitors
3	Ki Value [mM]
2	KM Value [mM]
19	Localization
10	Metals/Ions
3	Molecular Weight [Da]
16	Natural Substrates/ Products (Substrates)
54	Organism
6	PDB ID
4	pH Optimum
1	pH Range
4	Posttranslational Modification
8	Protein Variants
2	Purification (Commentary)
1	Reaction
1	Reaction Type
49	Reference
94	Source Tissue
2	Storage Stability
43	Substrates and Products (Substrate)
1	Subunits
73	Synonyms
2	Temperature Optimum [°C]
1	Turnover Number [1/s]

Engineering

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Engineering on EC 3.4.24.22 - stromelysin 2

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Homo sapiens

aldose reductase inhibitor, fidarestat, normalizes high-glucose level-mediated suppression of MMP-10 expression, it downregulates MMP-10 expression

708292

medicine

Homo sapiens

cells resistant to protein kinase C potentiated, transcription factor p53 mediated apoptosis express a higher level of matrix metalloproteinases MMP-9 and MMP-10. Matrix metalloproteinases function confers protection from protein kinase C/p53 induced apoptosis and are implicated in tumor cell resistance

668151

Homo sapiens

a high glucose level decreases MMP-10 expression in corneal epithelial cells

708292

V94G

Mus musculus

constitutively active mutant, mice expressing the mutant in keratinocytes have no alterations in skin architecture, and the healing rate of skin wounds is normal. Histologically, deposition of new matrix is reduced and keratinocytes at the migrating epidermal tip are scattered, the staining pattern of laminin-5 at the wound site is altered

670198

additional information

5 entries