3.4.24.22: stromelysin 2
This is an abbreviated version!
For detailed information about stromelysin 2, go to the full flat file.
Word Map on EC 3.4.24.22
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3.4.24.22
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metalloproteinases
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mmp-9
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collagen
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metastasis
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timps
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endothelial
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stromelysin-1
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gelatinase
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cartilage
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basement
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keratinocytes
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zymography
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matrilysin
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diagnostics
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collagenase-1
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collagenolytic
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medicine
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sdc1
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metalloelastase
- 3.4.24.22
- metalloproteinases
- mmp-9
- collagen
- metastasis
- timps
- endothelial
- stromelysin-1
- gelatinase
- cartilage
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basement
- keratinocytes
-
zymography
- matrilysin
- diagnostics
- collagenase-1
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collagenolytic
- medicine
- sdc1
- metalloelastase
Reaction
Similar to stromelysin 1, but action on collagen types III, IV and V is weak =
Synonyms
Matrix metalloproteinase 10, Matrix metalloproteinase-10, MMP-10, MMP10, More, Proteoglycanase 2, ST-2, stromelysin 2, stromelysin-2, Transformation-associated protein 34A, Transin 2, Transins, 2
ECTree
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Crystallization
Crystallization on EC 3.4.24.22 - stromelysin 2
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purified active human MMP-10 catalytic domain in complex with inhibitor protein TIMP-2, hanging drop vapor diffusion method, mixing of proteins in a 1:1.1 (mol/mol) ratio, 4.5-5.5 mg/ml protein in 20 mM Tris, pH 8.5 and 150 mM NaCl, are mixed with reservoir solution containing 0.1 M HEPES, pH 7.5, and 25% w/v PEG 2000 monomethyl ether, 1-2 weeks, X-ray diffraction structure determination and analysis at 2.1 A resolution, molecular replacement, comparison and analysis of the crystal structure of the human MMP-10/TIMP-1 complex, PDB ID 3V96
purified isolated catalytic enzyme domain in complex with inhibitor TIMP1, 1:1.2 (mol/mol) mixture of enzyme protein and fully deglycosylated TIMP-N30A mutant is concentrated to achieve a final protein concentration of 4-5 mg/ml. Crystals are grown by hanging drop vapor diffusion method at room temperature in 0.1 M sodium dihydrogen phosphate, pH 6.5, 12% w/v PEG 8000, 2 weeks, X-ray diffraction structure determination and analysis at 1.9 A resolution, molecular replacement
recombinant catalytic domain, in complex with inhibitor N-isobutyl-N-(4-methoxy-phenylsulfonyl)glycyl hydroxamic acid, i.e. NNGH. Comparison with structure of matrix metalloproteinase MMP-3
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