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3.4.24.22: stromelysin 2

This is an abbreviated version!
For detailed information about stromelysin 2, go to the full flat file.

Word Map on EC 3.4.24.22

Reaction

Similar to stromelysin 1, but action on collagen types III, IV and V is weak =

Synonyms

Matrix metalloproteinase 10, Matrix metalloproteinase-10, MMP-10, MMP10, More, Proteoglycanase 2, ST-2, stromelysin 2, stromelysin-2, Transformation-associated protein 34A, Transin 2, Transins, 2

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.24 Metalloendopeptidases
                3.4.24.22 stromelysin 2

Expression

Expression on EC 3.4.24.22 - stromelysin 2

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
enhanced collagen degradation, in case of epithelial-to-mesenchymal transition stimulated by transforming growth factor-beta as well as epidermal growth factor receptor, is coupled to a significant increase in matrix metalloproteinase MMP-10 expression and is involved a proteolytic axis composed of plasmin, MMP-10, and MMP-1, ec 3.4.24.7
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high expression of MMP-10 is frequently observed and is significantly correlated with the invasiveness and metastasis in head and neck squamous cell carcinoma cases
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increased MMP-10 levels in severe sepsis
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loss or knockdown of transcription factor CHF1/Hey2 in vascular smooth muscle cells leads to increased expression and activity of MMP10 at baseline. CHF1/Hey2 regulates MMP10 expression through multiple E boxes
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MMP-10 expression is downregulated with age, overview
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Mmp10 is overexpressed in lung tumors induced by either the smoke carcinogen urethane or oncogenic Kras
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neuronal MMP-10 is upregulated after stroke in brain in the infarcted tissue compared to healthy control areas, overview
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PD98059 and SP600125, ERK and JNK inhibitors, respectively, repress VEGF-induced MMP-10 expression to mRNA expression levels lower than the basal expression of MMP-10
stromelysin-2 is slightly downregulated in obese adipose tissue compared to non-obese adipose tissue
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strong positive correlation between tumor Mmp10 expression and metastatic behavior in many human tumor types
the gene for matrix metalloproteinase 10 is the most significantly upregulated gene in patients with systemic sclerosis (SSc)-associated pulmonary hypertension (PH)
VEGF165 induces MMP-10 expression about 2fold. LY294002 inhibits VEGF-induced MMP-10 expression, indicating the involvement of PI3K in VEGF-induced MMP-10 expression