3.4.24.22: stromelysin 2
This is an abbreviated version!
For detailed information about stromelysin 2, go to the full flat file.
Word Map on EC 3.4.24.22
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3.4.24.22
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metalloproteinases
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mmp-9
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collagen
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metastasis
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timps
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endothelial
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stromelysin-1
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gelatinase
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cartilage
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basement
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keratinocytes
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zymography
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matrilysin
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diagnostics
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collagenase-1
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collagenolytic
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medicine
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sdc1
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metalloelastase
- 3.4.24.22
- metalloproteinases
- mmp-9
- collagen
- metastasis
- timps
- endothelial
- stromelysin-1
- gelatinase
- cartilage
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basement
- keratinocytes
-
zymography
- matrilysin
- diagnostics
- collagenase-1
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collagenolytic
- medicine
- sdc1
- metalloelastase
Reaction
Similar to stromelysin 1, but action on collagen types III, IV and V is weak =
Synonyms
Matrix metalloproteinase 10, Matrix metalloproteinase-10, MMP-10, MMP10, More, Proteoglycanase 2, ST-2, stromelysin 2, stromelysin-2, Transformation-associated protein 34A, Transin 2, Transins, 2
ECTree
3.4.24.22 stromelysin 2Advanced search results
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results (Source Tissue
Source Tissue on EC 3.4.24.22 - stromelysin 2
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SOURCE TISSUE 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
SOURCE
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lymphoma cell, expression of enzyme is induced upon contact of cell with endothelial cells
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lymphoma cell, expression of enzyme is induced upon contact of cell with endothelial cells. Enzyme expression is also induced following exposure to interleukins IL-4, IL-6, and IL-13, but not IL-1
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MMP-10 is notably increased in neurons of the ischemic brain but not in healthy areas
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expression of matrix metalloproteinases MMP-1, MMP-7 and MMP-10 by migrating enterocytes bordering intestinal ulcers
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transformed embryo cell line, can be induced by a tumor promoter
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keratinocyte cell line, induction of enzyme and matrix metalloproteinases MMP-1 and MMP-3 by UVA, induction is suppressed by beta-carotene. beta-Carotene dose-dependently quenches 1O2-mediated induction of enzyme and MMP-1
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MMP-10 protein levels are higher in the tumor tissues than in the adjacent normal tissues
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no differences in MMP-10 in the plasma of hypertensive versus normotensive subjects
HUVEC, quantitative RT-PCR of MMPs, overview
additional information
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proenzyme expression is markedly induced in endothelial cells undergoing capillary tube morphogenesis. Enzyme-induced activation of matrix metalloproteinase MMP-1 correlates with tube regression and gel contraction
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in dysplastic epithelium MMP-10 is never expressed in basal keratinocytes
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in dysplastic epithelium MMP-10 is never expressed in basal keratinocytes
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alveolar mucosa stromelysin 2/MMP-10 expression is highest in the HIV1- and HIV1+ smokers with early emphysema, where it is significantly higher than in HIV1- healthy smokers, overview
enzyme Mmp10 is required for maintenance of a highly tumorigenic, cancer-initiating, metastatic stem-like cell population in lung cancer. Mmp10 and Notch4 expression in primary and metastatic lung tumors
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enzyme Mmp10 is required for maintenance of a highly tumorigenic, cancer-initiating, metastatic stem-like cell population in lung cancer. Mmp10 and Notch4 expression in primary and metastatic lung tumors
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isolated resident alveolar and bone marrow-derived macrophages (BMDM)
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isolated resident alveolar and bone marrow-derived macrophages (BMDM)
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quantitative detection of pro- and active forms of MMP-10 in blood from healthy subjects of both genders and different ages, overview. MMP-10 and TIMP-2 serum levels are age-dependently decreased. No significant differences among serum MMP-10 results for males versus females
antibody cross-reactivity due to the extreme similarity between MMP-3 (EC 3.4.24.17) and MMP-10 proteins
Mus musculus C57BL/KsOlaHsd-Db/+
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antibody cross-reactivity due to the extreme similarity between MMP-3 (EC 3.4.24.17) and MMP-10 proteins
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additional information
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gene expression of interleukin-1, nerve growth factor, and tumour necrosis factor-alpha does not correlate with matrix metalloproteinase-10 in human nucleus pulposus, but expression of substance P does correlate with MMP-10 expression, overview
additional information
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relationships between MMP-10 and TIMP-2 serum profiles, overview
additional information
MMP10 is overexpressed in the serum and pulmonary arteries of patients with SSc-associated PH, and its blockade alleviates PH in the Fra-2-Tg mouse model. Immunohistochemic analysis
additional information
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MMP10 is overexpressed in the serum and pulmonary arteries of patients with SSc-associated PH, and its blockade alleviates PH in the Fra-2-Tg mouse model. Immunohistochemic analysis
additional information
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stromelysin-2 expression analysis in 81 specimens, including 61 head and neck squamous cell carcinomas (different histological grades) and 20 non neoplastic epithelium, evaluation by immunohistochemistry
additional information
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with increasing epidermal hyperplasia, the amount of inflammatory infiltration increased and MMP-10 is also detected in suprabasal keratinocytes as the mice aged
additional information
strong positive correlation between tumor Mmp10 expression and metastatic behavior in many human tumor types. Oncosphere cultures exhibit Mmp10-dependent tumor-initiating activity in vivo
additional information
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strong positive correlation between tumor Mmp10 expression and metastatic behavior in many human tumor types. Oncosphere cultures exhibit Mmp10-dependent tumor-initiating activity in vivo
additional information
MMP10 (stromelysin-2) is not expressed in developing or normal adult tissues, including lung
additional information
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MMP10 (stromelysin-2) is not expressed in developing or normal adult tissues, including lung
additional information
MMP10 is overexpressed in the serum and pulmonary arteries of patients with SSc-associated PH, and its blockade alleviates PH in the Fra-2-Tg mouse model. Immunohistochemic analysis
additional information
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MMP10 is overexpressed in the serum and pulmonary arteries of patients with SSc-associated PH, and its blockade alleviates PH in the Fra-2-Tg mouse model. Immunohistochemic analysis
additional information
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strong positive correlation between tumor Mmp10 expression and metastatic behavior in many human tumor types. Oncosphere cultures exhibit Mmp10-dependent tumor-initiating activity in vivo
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additional information
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MMP10 (stromelysin-2) is not expressed in developing or normal adult tissues, including lung
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additional information
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with increasing epidermal hyperplasia, the amount of inflammatory infiltration increased and MMP-10 is also detected in suprabasal keratinocytes as the mice aged
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