3.4.23.B10: Rous sarcoma virus retropepsin

This is an abbreviated version!
For detailed information about Rous sarcoma virus retropepsin, go to the full flat file.

Reaction

The cleavage sequence in the natural substrate NC-PR is PPAVS-/-LAMTMRR. The activity can be improved by substitution by Trp, Tyr, Phe, Leu, Arg, Glu, His or Ala in P1, Tyr in P3', and Arg, Phe, Asn or His in P3 =

Synonyms

AMV PR, AMV/RSV PR, avian myeloblastosis virus protease, avian myeloblastosis virus retropepsin, capsid protein P27, core protein P10, core protein P19, core protein P2A, core protein P2B, Gag polyprotein, Gag polyprotein p10 sequence, inner coat protein P12, More, p10-CA protease, p10-capsid protease, p15 protein, protease P15, Rous sarcoma virus protease, Rous sarcoma virus retropepsin, RSV PR, RSV protease, RSV/AMV retropepsin, viral protease

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.23 Aspartic endopeptidases

                3.4.23.B10 Rous sarcoma virus retropepsin

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Results	in table
1	Activating Compound
2	AA Sequence
2	Application
1	CAS Registry Number
6	Cloned(Commentary)
5	Crystallization (Commentary)
2	General Information
2	Inhibitors
2	Ki Value [mM]
28	KM Value [mM]
1	Localization
5	Metals/Ions
2	Molecular Weight [Da]
13	Natural Substrates/ Products (Substrates)
42	Organism
4	pH Optimum
1	pH Range
3	Posttranslational Modification
48	Protein Variants
5	Purification (Commentary)
4	Reaction
1	Reaction Type
29	Reference
1	Renatured (Commentary)
3	Source Tissue
90	Substrates and Products (Substrate)
7	Subunits
29	Synonyms
42	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 3.4.23.B10 - Rous sarcoma virus retropepsin

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

Gag polyprotein precursor + H2O

?

2 entries

gag precursor polyprotein + H2O

?

5 entries

Gag-Pol precursor polyprotein + H2O

?

3 entries

additional information

?

-

3 entries

Gag polyprotein precursor + H2O

?

Rous sarcoma virus

-

cleavage into several different mature proteins, processing by the p10 sequence portion of the Gag-polyprotein C-terminus

670089

-

-

?

Gag polyprotein precursor + H2O

?

Rous sarcoma virus

-

maturation, processing by the p10-capsid protease sequence of the Gag-polyprotein C-terminus

670871

-

-

?

gag precursor polyprotein + H2O

?

Avian myeloblastosis virus

-

cleavage into several different mature proteins, processing by the avian myoblastosis retropepsin, which is part of the Gag-polyprotein and located at the C-terminus

668795

-

-

?

gag precursor polyprotein + H2O

?

Avian myeloblastosis virus AMV

-

cleavage into several different mature proteins, processing by the avian myoblastosis retropepsin, which is part of the Gag-polyprotein and located at the C-terminus

668795

-

-

?

gag precursor polyprotein + H2O

?

Rous sarcoma virus

-

the p2 region of RSV Gag, particularly the Pro-Pro-Pro-Tyr motif is important in the processing of the gag precursor polyprotein, most probably by controlling the activation of the virally encoded protease

647775

-

-

?

gag precursor polyprotein + H2O

?

Rous sarcoma virus

-

viral protein maturation occurs after protease subunits are released from the Gag polyprotein

647778

-

-

?

gag precursor polyprotein + H2O

?

Rous sarcoma virus

-

cleavage into several different mature proteins, processing by the p15 protein or rous sarcoma virus retropepsin, which is part of the Gag-polyprotein and located at the C-terminus

668795

-

-

?

Gag-Pol precursor polyprotein + H2O

?

Avian myeloblastosis virus

-

cleavage into several different mature proteins

668795

-

-

?

Gag-Pol precursor polyprotein + H2O

?

Avian myeloblastosis virus AMV

-

cleavage into several different mature proteins

668795

-

-

?

Gag-Pol precursor polyprotein + H2O

?

Rous sarcoma virus

-

cleavage into several different mature proteins

668795

-

-

?

additional information

?

-

Rous sarcoma virus

-

the enzyme is an intrinsic part of the virus assembly responsible for coordination of the process

670089

-

-

?

additional information

?

-

Rous sarcoma virus

-

the enzyme is an intrinsic part of the virus assembly responsible for coordination of the process, enzyme inhibition blocks the virus replication

670871

-

-

?

additional information

?

-

Rous sarcoma virus

-

the enzyme cleaves the RSV Gag protein and virus-like particles (VLPs)

754541

-

-

?