Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.23.B10 extracted from

  • Vana, M.L.; Chen, A.; Boross, P.; Weber, I.; Colman, D.; Barklis, E.; Leis, J.
    Mutations affecting cleavage at the p10-capsid protease cleavage site block Rous sarcoma virus replication (2005), Retrovirology, 2, 58.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.23.B10

Cloned(Commentary)

Cloned (Comment) Organism
expression of wild-type and mutant enzymes in DF-1 cells Rous sarcoma virus

Protein Variants

Protein Variants Comment Organism
M239F site-directed mutagenesis of the p10-capsid protease sequence of Gag polyprotein does not affect the enzyme activity and virus replication Rous sarcoma virus
M239G site-directed mutagenesis of the p10-capsid protease sequence of Gag polyprotein abolishes the enzyme activity and blocks Rous sarcoma virus replication, detrimental effect, overview Rous sarcoma virus
P240F site-directed mutagenesis of the p10-capsid protease sequence of Gag polyprotein abolishes the enzyme activity and blocks Rous sarcoma virus replication, detrimental effect, overview Rous sarcoma virus
V241G site-directed mutagenesis of the p10-capsid protease sequence of Gag polyprotein abolishes the enzyme activity and blocks Rous sarcoma virus replication, detrimental effect, overview Rous sarcoma virus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Gag polyprotein precursor + H2O Rous sarcoma virus maturation, processing by the p10-capsid protease sequence of the Gag-polyprotein C-terminus ?
-
 ?
additional information Rous sarcoma virus the enzyme is an intrinsic part of the virus assembly responsible for coordination of the process, enzyme inhibition blocks the virus replication ?
-
 ?

Organism

Organism UniProt Comment Textmining
Rous sarcoma virus
-
 RSV
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Gag polyprotein precursor + H2O maturation, processing by the p10-capsid protease sequence of the Gag-polyprotein C-terminus Rous sarcoma virus ?
-
 ?
Gag polyprotein precursor + H2O processing by the p10-capsid protease sequence of the Gag-polyprotein C-terminus, specific cleavage site Rous sarcoma virus ?
-
 ?
additional information the enzyme is an intrinsic part of the virus assembly responsible for coordination of the process, enzyme inhibition blocks the virus replication Rous sarcoma virus ?
-
 ?

Synonyms

Synonyms Comment Organism
p10-CA protease
-
 Rous sarcoma virus
p10-capsid protease
-
 Rous sarcoma virus