3.4.23.B10: Rous sarcoma virus retropepsin

This is an abbreviated version!
For detailed information about Rous sarcoma virus retropepsin, go to the full flat file.

Reaction

The cleavage sequence in the natural substrate NC-PR is PPAVS-/-LAMTMRR. The activity can be improved by substitution by Trp, Tyr, Phe, Leu, Arg, Glu, His or Ala in P1, Tyr in P3', and Arg, Phe, Asn or His in P3 =

Synonyms

AMV PR, AMV/RSV PR, avian myeloblastosis virus protease, avian myeloblastosis virus retropepsin, capsid protein P27, core protein P10, core protein P19, core protein P2A, core protein P2B, Gag polyprotein, Gag polyprotein p10 sequence, inner coat protein P12, More, p10-CA protease, p10-capsid protease, p15 protein, protease P15, Rous sarcoma virus protease, Rous sarcoma virus retropepsin, RSV PR, RSV protease, RSV/AMV retropepsin, viral protease

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.23 Aspartic endopeptidases

                3.4.23.B10 Rous sarcoma virus retropepsin

Advanced search results

Do not include text mining results

Include results (more...)

Include results (more...)

Results	in table
1	Activating Compound
2	AA Sequence
2	Application
1	CAS Registry Number
6	Cloned(Commentary)
5	Crystallization (Commentary)
2	General Information
2	Inhibitors
2	Ki Value [mM]
28	KM Value [mM]
1	Localization
5	Metals/Ions
2	Molecular Weight [Da]
13	Natural Substrates/ Products (Substrates)
42	Organism
4	pH Optimum
1	pH Range
3	Posttranslational Modification
48	Protein Variants
5	Purification (Commentary)
4	Reaction
1	Reaction Type
29	Reference
1	Renatured (Commentary)
3	Source Tissue
90	Substrates and Products (Substrate)
7	Subunits
29	Synonyms
42	Turnover Number [1/s]

Purification

print visible entries

print all entries

Go back to the abbreviated version
of the Enzyme Summary Page.

Purification on EC 3.4.23.B10 - Rous sarcoma virus retropepsin

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide Go to Purification (commentary) Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

PURIFICATION (Commentary)

ORGANISM

UNIPROT

LITERATURE

-

Rous sarcoma virus

P03322

490085

mutant and wild-type enzymes

Rous sarcoma virus

-

647780

native enzyme from whole virus

Avian myeloblastosis virus

-

668795

recombinant wild-type and mutant enzymes from Escherichia coli with refolding from inclusion bodies to over 95% purity, N-terminally His-tagged enzyme from Escherichia coli soluble fraction by nickel affinity chromatography

Rous sarcoma virus

-

668795

wild-type and mutant linked-dimer RSV protease

Rous sarcoma virus

-

647772