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3.4.23.B10: Rous sarcoma virus retropepsin

This is an abbreviated version!
For detailed information about Rous sarcoma virus retropepsin, go to the full flat file.

Word Map on EC 3.4.23.B10

Reaction

The cleavage sequence in the natural substrate NC-PR is PPAVS-/-LAMTMRR. The activity can be improved by substitution by Trp, Tyr, Phe, Leu, Arg, Glu, His or Ala in P1, Tyr in P3', and Arg, Phe, Asn or His in P3 =

Synonyms

AMV PR, AMV/RSV PR, avian myeloblastosis virus protease, avian myeloblastosis virus retropepsin, capsid protein P27, core protein P10, core protein P19, core protein P2A, core protein P2B, Gag polyprotein, Gag polyprotein p10 sequence, inner coat protein P12, More, p10-CA protease, p10-capsid protease, p15 protein, protease P15, Rous sarcoma virus protease, Rous sarcoma virus retropepsin, RSV PR, RSV protease, RSV/AMV retropepsin, viral protease

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.23 Aspartic endopeptidases
                3.4.23.B10 Rous sarcoma virus retropepsin

Reference

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Reference on EC 3.4.23.B10 - Rous sarcoma virus retropepsin

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Schwartz, D.E.; Tizard, R.; Gilbert, W.
Nucleotide sequence of Rous sarcoma virus
Cell
32
853-869
1983
Rous sarcoma virus (P03322), Rous sarcoma virus Prague C (P03322)
Manually annotated by BRENDA team
Misono K.S.; Sharief F.S.; Leis J.
Primary structure of Rous sarcoma virus RNA-associated polypeptide
Fed. Proc.
39
1611-1611
1980
Rous sarcoma virus (P03322), Rous sarcoma virus Prague C (P03322)
-
Manually annotated by BRENDA team
Miller M.; Jaskolski M.; Rao J.K.M.; Leis J.; Wlodawer A.
Crystal structure of a retroviral protease proves relationship to aspartic protease family
Nature
337
576-579
1989
Rous sarcoma virus (P03322), Rous sarcoma virus Prague C (P03322)
Manually annotated by BRENDA team
McDonnell J.M.; Fushman D.; Cahill S.M.; Zhou W.; Wolven A.; Wilson C.B.; Nelle T.D.; Resh M.D.; Wills J.; Cowburn D.
Solution structure and dynamics of the bioactive retroviral M domain from Rous sarcoma virus
J. Mol. Biol.
279
921-928
1998
Rous sarcoma virus (P03322), Rous sarcoma virus Prague C (P03322)
Manually annotated by BRENDA team
Wu, J.; Adomat, J.M.; Ridky, T.W.; Louis, J.M.; Leis, J.; Harrison, R.W.; Weber, I.T.
Structural Basis for Specificity of Retroviral Proteases
Biochemistry
37
4518-4526
1998
Rous sarcoma virus
Manually annotated by BRENDA team
Ridky, T.W.; Bizub-Bender, D.; Cameron, C.E.; Weber, I.T.; Wlodawer, A.; Copeland, T.; Skalka, A.M.; Leis, J.
Programming the Rous sarcoma virus protease to cleave new substrate sequences
J. Biol. Chem.
271
10538-10544
1996
Rous sarcoma virus
Manually annotated by BRENDA team
Dong, J.Y.; Dubay, J.W.; Perez, L.G.; Hunter, E.
Mutations within the proteolytic cleavage site of the Rous sarcoma virus glycoprotein define a requirement for dibasic residues for intracellular cleavage
J. Virol.
66
865-874
1992
Rous sarcoma virus
Manually annotated by BRENDA team
Cameron, C.E.; Burstein, H.; Bizub-Bender, D.; Ridky, T.; Weber, I.T.; Wlodawer, A.; Skalka, A.M.; Leis, J.
Identification of amino acid residues of the retroviral aspartic proteinases important for substrate specificity and catalytic efficiency
Adv. Exp. Med. Biol.
362
399-406
1995
Rous sarcoma virus
Manually annotated by BRENDA team
Bowles, N.; Bonnet, D.; Mulhauser, F.; Spahr, P.F.
Site-directed mutagenesis of the p2 region of the Rous sarcoma virus gag gene: effects on Gag polyprotein processing
Virology
203
20-28
1994
Rous sarcoma virus
Manually annotated by BRENDA team
Grinde, B.; Cameron, C.E.; Leis, J.; Weber, I.T.; Wlodawer, A.; Burstein, H.; Bizub, D.; Skalka, A.M.
Mutations that alter the activity of the Rous sarcoma virus protease
J. Biol. Chem.
267
9481-9490
1992
Rous sarcoma virus
Manually annotated by BRENDA team
Cameron, C.E.; Ridky, T.W.; Shulenin, S.; Leis, J.; Weber, I.T.; Copeland, T.; Wlodawer, A.; Burstein, H.; Bizub-Bender, D.; Skalka, A.M.
Mutational analysis of the substrate binding pockets of the Rous sarcoma virus and human immunodeficiency virus-1 proteases
J. Biol. Chem.
269
11170-11177
1994
Rous sarcoma virus
Manually annotated by BRENDA team
Xiang, Y.; Ridky, T.W.; Krishna, N.K.; Leis, J.
Altered Rous sarcoma virus Gag polyprotein processing and its effects on particle formation
J. Virol.
71
2083-2091
1997
Rous sarcoma virus
Manually annotated by BRENDA team
Grinde, B.; Cameron, C.E.; Leis, J.; Weber, I.T.; Wlodawer, A.; Burstein, H.; Skalka, A.M.
Analysis of substrate interactions of the Rous sarcoma virus wild type and mutant proteases and human immunodeficiency virus-1 protease using a set of systematically altered peptide substrates
J. Biol. Chem.
267
9491-9498
1992
Rous sarcoma virus
Manually annotated by BRENDA team
Schatz, G.W.; Reinking, J.; Zippin, J.; Nicholson, L.K.; Vogt, V.M.
Importance of the N terminus of rous sarcoma virus protease for structure and enzymatic function
J. Virol.
75
4761-4770
2001
Rous sarcoma virus
Manually annotated by BRENDA team
Cameron, C.E.; Grinde, B.; Jacques, P.; Jentoft, J.; Leis, J.; Wlodawer, A.; Weber, I.T.
Comparison of the substrate-binding pockets of the Rous sarcoma virus and human immunodeficiency virus type 1 proteases
J. Biol. Chem.
268
11711-11720
1993
Rous sarcoma virus
Manually annotated by BRENDA team
Weber, I.T.; Harrison, R.W.
Molecular mechanics calculations on Rous sarcoma virus protease with peptide substrates
Protein Sci.
6
2365-2374
1997
Rous sarcoma virus
Manually annotated by BRENDA team
Leis, J.
Rous sarcoma virus retropepsin and avian myeloblastosis virus retropepsin
Handbook of Proteolytic Enzymes (Barrett, J. ; Rawlings, N. D. ; Woessner, J. F. , eds. )
1
163-166
2004
Avian myeloblastosis virus, Rous sarcoma virus, Avian myeloblastosis virus AMV
-
Manually annotated by BRENDA team
Scheifele, L.Z.; Ryan, E.P.; Parent, L.J.
Detailed mapping of the nuclear export signal in the Rous sarcoma virus Gag protein
J. Virol.
79
8732-8741
2005
Rous sarcoma virus
Manually annotated by BRENDA team
Vana, M.L.; Chen, A.; Boross, P.; Weber, I.; Colman, D.; Barklis, E.; Leis, J.
Mutations affecting cleavage at the p10-capsid protease cleavage site block Rous sarcoma virus replication
Retrovirology
2
58
2005
Rous sarcoma virus
Manually annotated by BRENDA team
Eizert, H.; Bander, P.; Bagossi, P.; Sperka, T.; Miklossy, G.; Boross, P.; Weber, I.T.; Toezser, J.
Amino acid preferences of retroviral proteases for amino-terminal positions in a type 1 cleavage site
J. Virol.
82
10111-10117
2008
Avian myeloblastosis virus
Manually annotated by BRENDA team
Tsuji, Y.; Deo, V.K.; Kato, T.; Park, E.Y.
Production of Rous sarcoma virus-like particles displaying human transmembrane protein in silkworm larvae and its application to ligand-receptor binding assay
J. Biotechnol.
155
185-192
2011
Rous sarcoma virus
Manually annotated by BRENDA team
Qian, K.; Liang, Y.Z.; Yin, L.P.; Shao, H.X.; Ye, J.Q.; Qin, A.J.
Development and evaluation of an immunochromatographic strip for rapid detection of capsid protein antigen p27 of avian leukosis virus
J. Virol. Methods
221
115-118
2015
Avian leukosis virus - RSA (Q04095)
Manually annotated by BRENDA team
Schur, F.K.; Dick, R.A.; Hagen, W.J.; Vogt, V.M.; Briggs, J.A.
The structure of immature virus-like Rous sarcoma virus Gag particles reveals a structural role for the p10 domain in assembly
J. Virol.
89
10294-10302
2015
Rous sarcoma virus
Manually annotated by BRENDA team