3.4.23.B1: napsin
This is an abbreviated version!
For detailed information about napsin, go to the full flat file.
Word Map on EC 3.4.23.B1
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3.4.23.B1
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adenocarcinoma
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thyroid
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pulmonary
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resect
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cytokeratins
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non-small
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factor-1
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papillary
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immunophenotype
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alk
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endometrioid
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synaptophysin
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chromogranin
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adenosquamous
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medicine
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calretinin
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analysis
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lepidic
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a-positive
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diagnostics
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immunomarkers
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nonpulmonary
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sarcomatoid
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immunoprofile
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amacr
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micropapillary
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cytopathol
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mammaglobin
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mucicarmine
- 3.4.23.B1
- adenocarcinoma
- thyroid
- pulmonary
-
resect
-
cytokeratins
-
non-small
- factor-1
-
papillary
-
immunophenotype
- alk
-
endometrioid
-
synaptophysin
-
chromogranin
-
adenosquamous
- medicine
-
calretinin
- analysis
-
lepidic
-
a-positive
- diagnostics
-
immunomarkers
-
nonpulmonary
-
sarcomatoid
-
immunoprofile
- amacr
-
micropapillary
-
cytopathol
-
mammaglobin
-
mucicarmine
Reaction
belongs to the aspartic proteinases =
Synonyms
napsin, napsin A, napsin-A, TA02 protein, TAO2
ECTree
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analysis
diagnostics
medicine
enzyme is a specific marker in diagnosis of primary lung adenocarcinoma and to distinguish it from metastatic adenocarcinoma
analysis
identification of suitable fluorogenic protease substrates for the pharmaceutically important napsin A by an easy, solid-phase combinatorial assay technology
napsin A is a reliable marker for pulmonary adenocarcinoma and is expressed in a subset of ovarian clear cell carcinomas (O-CCCs), endometrial (EM) CCCs, and endometrioid carcinomas (EC). Napsin A levels in O-CCC and EM-CCC are analyzed and compared with levels in other nonmucinous ovarian carcinomas and EM-EC, respectively. But for diagnostics of napsin A expression in Arias-Stella reactions, napsin A expression is frequently present in foci of Arias-Stella reaction, a feature that they share with clear cell carcinomas. Therefore, Napsin A, in and of itself, is of minimal utility in this specific differential diagnostic scenario
diagnostics
napsin A is an intracellular aspartic protease and biomarker of various malignancies like lung adenocarcinoma and ovarian clear cell carcinoma
diagnostics
napsin A is another sensitive and specific marker for distinguishing ovarian clear cell tumors (especially adenocarcinomas) from other ovarian tumor
diagnostics
A0A5F4D0L0
napsin A is useful as a biomarker. Napsin A is as sensitive as calcitonin for C-cell neoplasms, but is less sensitive than thyroglobulin for follicular neoplasms. The tested markers are sensitive and, except for renal cell carcinoma (for Pax8, napsin A) and pulmonary adenocarcinoma (for napsin A), they are specific thyroid tumour markers
diagnostics
napsin A, is useful as a marker of ovarian clear cell carcinoma, immunohistochemical study with 279 ovarian tumour samples, overview. Napsin A detection is specific but of intermediate sensitivity as a biomarker
enzyme is a specific marker in diagnosis of primary lung adenocarcinoma and to distinguish it from metastatic adenocarcinoma
medicine
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napsin A is useful to distinguish primary lung adenocarcinoma from adenocarcinomas of other organs
medicine
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observation that napsin A is expressed in more than 90% of primary lung adenocarcinomas but not in other malignancies shows that napsin A might be a marker for this type of carcinoma. Potential use as a marker for kidney dysfunction
medicine
immunocytochemical markers for lung adenocarcinoma, identification of malignancy in effusions
medicine
studies on differentiation of primary from secondary effects in the pathogenesis of juvenile and adult forms of Pulmonary alveolar proteinosis
medicine
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napsin-A is a marker for lung adenocarcinoma, napsin-A is useful as a surrogate marker when encountering a poorly differentiated lung adenocarcinoma or an unknown primary tumor
medicine
napsin-A is useful for stages IA and IIIA and also related to regional lymph node metastasis, napsin-A contents correlate with better prognosis in stage IA
medicine
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among 10 probes of surgically resected sclerosing haemangioma, all tumours have diffuse and intense expression of napsin A in cuboidal superficial cells, whereas the round interstitial component is completely negative in four cases, and shows focal granular cytoplasmic positivity in six cases
medicine
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use of napsin A to distinguish between metastatic pulmonary and non-pulmonary adenocarvcinomas in cell blocks prepared from malignant pleural effusions. Napsin A is positive in 83% of pulmonary adenocarcinomas tested, while thyroid transcription factor TTF-1 is positive in 57% of pulmonary adenocarcinomas. All non-pulmonary adenocarcinoas tested are negative for napsin A and TTF-1. Napsin A shows a reactivity in more than 75% of the tumor cells in 82% of the positive cases, whereas TTF-1 shows a reactivity in more than 75% of the tumor cells only in 20% of the positive cases
medicine
napsin A is expressed in a wider variety of metastatic nonpulmonary carcinomas than thyroid transcription factorTTF-1, and the monoclonal antibody is more specific. Napsin A is a useful adjunct to TTF-1, because occasional lung adenocarcinomas are TTF-1 negative but napsin A positive
medicine
napsin A is frequently expressed in ovarian clear cell carcinomas and endometrian clear cell carcinomas, rarely in ovarian endometroid carcinomas and endometrian endometroid carcinomas, and never in high-grade serous carcinoma cases. Findings confirm the importance of using a panel of antibodies that includes napsin A, TTF-1, and PAX8 when evaluating metastatic carcinomas of unknown origin
medicine
napsin A staining occurs commonly in the surface cells and less commonly in the round cell component of sclerosing hemangioma, supporting a respiratory epithelial (specifically type II pneumocyte) origin for this tumor. Cytokeratin and TTF-1 staining in surface cells and TTF-1 staining with only weak and inconsistent cytokeratin staining in round cells confirms studies suggesting primitive or incompletely differentiated respiratory epithelium as the likely cell of origin for stromal round cells