3.4.23.B1: napsin
This is an abbreviated version!
For detailed information about napsin, go to the full flat file.
Word Map on EC 3.4.23.B1
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3.4.23.B1
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adenocarcinoma
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thyroid
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pulmonary
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resect
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cytokeratins
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non-small
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factor-1
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papillary
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immunophenotype
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alk
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endometrioid
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synaptophysin
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chromogranin
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adenosquamous
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medicine
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calretinin
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analysis
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lepidic
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a-positive
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diagnostics
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immunomarkers
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nonpulmonary
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sarcomatoid
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immunoprofile
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amacr
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micropapillary
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cytopathol
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mammaglobin
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mucicarmine
- 3.4.23.B1
- adenocarcinoma
- thyroid
- pulmonary
-
resect
-
cytokeratins
-
non-small
- factor-1
-
papillary
-
immunophenotype
- alk
-
endometrioid
-
synaptophysin
-
chromogranin
-
adenosquamous
- medicine
-
calretinin
- analysis
-
lepidic
-
a-positive
- diagnostics
-
immunomarkers
-
nonpulmonary
-
sarcomatoid
-
immunoprofile
- amacr
-
micropapillary
-
cytopathol
-
mammaglobin
-
mucicarmine
Reaction
belongs to the aspartic proteinases =
Synonyms
napsin, napsin A, napsin-A, TA02 protein, TAO2
ECTree
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Source Tissue
Source Tissue on EC 3.4.23.B1 - napsin
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bronchoalveolar lavage fluid (BALF), expression in
the distribution of histotypes for 279 ovarian tumours are analysed
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weak detection of napsin A in cytoplasm of lung sarcomatoid carcinoma cells
A0A5F4D0L0
napsin A is expressed mainly by C-cells in thyroid tumors
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enzymatically active napsin A can be detected in urine of healthy individuals or in patients with transplanted kidney whose kidney function appears half to fully normal. Low activity in samples from patients with diseased kidneys
additional information
re-expression of napsin A in tumorigenic HEK293 kidney cell line, reduced capacity for anchorage-independent growth observed
proximal tubule, expression patterns determined by in situ hybridization
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napsin-A is strongly expressed in the normal lung tissue (macrophages and pneumocytes)
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primary, napsin A is expressed in more than 90% of primary lung adenocarcinomas but not in other malignancies
expression in only one of 29 renal cell carcinomas determined, correlation to loss of napsin A expression in high-grade lung adenocarcinomas
A0A5F4D0L0
immunohistochemic enzyme detection, overview
additional information
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napsin is not expressed at primary sites or metastatic sites of adenocarcinomas of other organs than lung. Napsin is not expressed at primary sites of other types of lung carcinomas than adenocarcinomas
additional information
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napsin-A is not detected in small cell carcinomas or in other carcinomas of nonlung origin except for renal cell carcinoma. Napsin-A expression is absent in control lymph node and gastrointestinal sections
additional information
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no detection of napsin A in squamous cell carcinoma cell, colonic adenocarcinoma cell, pancreatic adenocarcinoma cell, breast adenocarcinoma cell, and malignant mesothelioma cell
additional information
in the endometrium, one lesion in the differential diagnosis of clear cell carcinoma is the nonneoplastic, progestin-related alteration, Arias-Stella reaction. Napsin A is frequently expressed in ovarian clear cell carcinomas (O-CCCs) and endometrial (EM) CCCs, but rarely in ovarian carcinomas (O-EC) and endometrioid carcinomas (EM-EC), and never in high-grade serous carcinoma [HGSC] cases
additional information
napsin A is predominantly expressed in lung and kidney. Lung napsin A in many mammals is a heterogeneous enzyme with a characteristic ladder-like appearance in SDS-PAGE that might be caused by proteolytically processed N- and/or C-termini, in contrast to the more homogeneous form found in kidneys and primary lung adenocarcinoma
additional information
no expression is observed in 30 serous adenocarcinomas, 11 serous adenomas or borderline tumors, 19 endometrioid adenocarcinomas, 22 mucinous adenomas or borderline tumors, 10 mucinous adenocarcinomas, or 3 yolk sac tumors of the ovary. Expression of napsin A is also not observed in the normal surface epithelium of the ovary, epithelia of the fallopian tubes, squamous epithelium, endocervical epithelium, or the endometrium of the uterus
additional information
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no expression is observed in 30 serous adenocarcinomas, 11 serous adenomas or borderline tumors, 19 endometrioid adenocarcinomas, 22 mucinous adenomas or borderline tumors, 10 mucinous adenocarcinomas, or 3 yolk sac tumors of the ovary. Expression of napsin A is also not observed in the normal surface epithelium of the ovary, epithelia of the fallopian tubes, squamous epithelium, endocervical epithelium, or the endometrium of the uterus
additional information
no napsin A expression in six steroid cell tumours, 18 adult-type granulosa cell tumours, eight dysgerminomas, and nine other miscellaneous tumour types. Napsin A detection is specific but of intermediate sensitivity as a biomarker. Immunohistochemic analysis, overview
additional information
no activity and mRNA expression in B-lymphocytes