Literature summary for 3.4.23.B1 extracted from

Iwamoto, M.; Nakatani, Y.; Fugo, K.; Kishimoto, T.; Kiyokawa, T.
Napsin A is frequently expressed in clear cell carcinoma of the ovary and endometrium (2015), Hum. Pathol., 46, 957-962 .

Search for more literature for 3.4.23.B1

Application

Application	Comment	Organism
diagnostics	napsin A is a reliable marker for pulmonary adenocarcinoma and is expressed in a subset of ovarian clear cell carcinomas (O-CCCs), endometrial (EM) CCCs, and endometrioid carcinomas (EC). Napsin A levels in O-CCC and EM-CCC are analyzed and compared with levels in other nonmucinous ovarian carcinomas and EM-EC, respectively. But for diagnostics of napsin A expression in Arias-Stella reactions, napsin A expression is frequently present in foci of Arias-Stella reaction, a feature that they share with clear cell carcinomas. Therefore, Napsin A, in and of itself, is of minimal utility in this specific differential diagnostic scenario	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
enzyme expression analysis	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytoplasm	-	Homo sapiens	5737	-
additional information	foci of Arias-Stella reaction are napsin A positive, expression analysis	Homo sapiens	-	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	O96009	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
endometrial clear cell carcinoma cell	-	Homo sapiens	-
additional information	in the endometrium, one lesion in the differential diagnosis of clear cell carcinoma is the nonneoplastic, progestin-related alteration, Arias-Stella reaction. Napsin A is frequently expressed in ovarian clear cell carcinomas (O-CCCs) and endometrial (EM) CCCs, but rarely in ovarian carcinomas (O-EC) and endometrioid carcinomas (EM-EC), and never in high-grade serous carcinoma [HGSC] cases	Homo sapiens	-
ovarian clear cell carcinoma cell	-	Homo sapiens	-
uterine endometrium	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
napsin A	-	Homo sapiens

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Release 2023.1 (January 2023)