3.4.23.24: Candidapepsin

This is an abbreviated version, for detailed information about Candidapepsin, go to the full flat file.

Reaction

Preferential cleavage at the carboxyl of hydrophobic amino acids, but fails to cleave Leu15-Tyr, Tyr16-Leu and Phe24-Phe of insulin B chain. Activates trypsinogen, and degrades keratin =

Synonyms

Aspartate protease, aspartic protease, aspartic protease 2, aspartic protease Sap2p, aspartic proteinase 3, aspartyl protease Sap2p, aspartyl protease Sap4, aspartyl protease Sap5, aspartyl protease Sap6, aspartyl proteinase, candialbicin, Candida albicans aspartic proteinase, Candida albicans carboxyl proteinase, Candida albicans secretory acid proteinase, Candida albicans-secreted aspartic proteinase, Candida olea acid proteinase, Candidapepsin-1, candidapepsin-2, EC 3.4.23.6, Proteinase, Candida albicans aspartic, Proteinase, Candida aspartic, Proteinase, Candida olea aspartic, SAP, SAP1, Sap10, SAP11, Sap1p, SAP2, Sap2p, SAP2X, SAP3, Sap3p, SAP4, Sap4p, SAP5, Sap5p, SAP6, Sap6p, Sap7, Sap7p, Sap8, Sap8p, Sap9, Sap9p, Sapp1p, Sapp2p, SAPT1, Sapt1p, SAPT2, SAPT3, SAPT4, secreted aspartic protease, secreted aspartic protease 1, secreted aspartic proteinase, secreted aspartic proteinase 1, secreted aspartic proteinase 2, secreted aspartic proteinase-2, secreted aspartyl peptidase, secreted aspartyl protease, secreted aspartyl proteinase, secreted aspartyl proteinase2, secreted aspartyl proteinases, secreted aspartyl-type peptidase, secretory aspartyl proteinase, secretory aspartyl proteinase SAP1, secretory aspartyl proteinase SAP2p, secretory aspartyl proteinase SAP3p, secretory aspartyl proteinase SAP4p, secretory aspartyl proteinase SAP5p, secretory aspartyl proteinase SAP6p

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.23 Aspartic endopeptidases
                3.4.23.24 Candidapepsin

Reference

Reference on EC 3.4.23.24 - Candidapepsin

Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Ruchel, R.
Properties of a purified proteinase from the yeast Candida albicans
Biochim. Biophys. Acta
659
99-113
1981
Candida albicans, Candida albicans CBS-2730
Manually annotated by BRENDA team
Remold, H.; Fasold, H.; Staib, F.
Purification and characterization of a proteolytic enzyme from Candida albicans
Biochim. Biophys. Acta
167
399-406
1968
Candida albicans
Manually annotated by BRENDA team
Lott, T.J.; Page, L.S.; Boiron, P.; Benson, J.; Reiss, E.
Nucleotide sequence of the Candida albicans aspartyl proteinase gene
Nucleic Acids Res.
17
1779
1989
Candida albicans
Manually annotated by BRENDA team
Wright, R.J.; Carne, A.; Hieber, A.D.; Lamont, I.L.; Emerson, G.W.; Sullivan, P.A.
A second gene for a secreted aspartate proteinase in Candida albicans
J. Bacteriol.
174
7848-7853
1992
Candida albicans
Manually annotated by BRENDA team
White, T.C.; Miyasaki, S.H.; Agabian, N.
Three distinct secreted aspartyl proteinases in Candida albicans
J. Bacteriol.
175
6126-6133
1993
Candida albicans
Manually annotated by BRENDA team
Morrison, C.J.; Hurst, S.F.; Bragg, S.L.; Kuykendall, R.J.; Diaz, H.; McLaughlin, D.W.; Reiss, E.
Purification and characterization of the extracellular aspartyl proteinase of Candida albicans: removal of extraneous proteins and cell wall mannoprotein and evidence for lack of glycosylation
J. Gen. Microbiol.
139
1177-1186
1993
Candida albicans
Manually annotated by BRENDA team
Homma, M.; Chibana, H.; Tanaka, K.
Induction of extracellular proteinase in Candida albicans
J. Gen. Microbiol.
139
1187-1193
1993
Candida albicans
Manually annotated by BRENDA team
Cutfield, S.; Marshall, C.; Moody, P.; Sullivan, P.; Cutfield, J.
Crystallization of inhibited aspartic proteinase from Candida albicans
J. Mol. Biol.
234
1266-1269
1993
Candida albicans
Manually annotated by BRENDA team
Gotoh, T.; Kikuchi, K.; Kodama, K.; Konno, H.; Kakuta, T.; Koizumi, T.; Nojiro, K.
Purification and properties of extracellular carboxyl proteinase secreted by Candida pulcherrima
Biosci. Biotechnol. Biochem.
59
367-371
1995
Metschnikowia pulcherrima, Metschnikowia pulcherrima KSY 188-5
Manually annotated by BRENDA team
Portillo, F.; Gancedo, C.
Purification and properties of three intracellular proteinases from Candida albicans
Biochim. Biophys. Acta
881
229-235
1986
Candida albicans
Manually annotated by BRENDA team
Nelson, G.; Young, T.W.
Extracellular acid and alkaline proteases from Candida olea
J. Gen. Microbiol.
133
1461-1469
1987
Candida olea 148, Candida olea
Manually annotated by BRENDA team
Ruechel, R.; Boening, B.; Jahn, E.
Identification and partial characterization of two proteinases from the cell envelope of Candida albicans blastospores
Zentralbl. Bakteriol. Mikrobiol. Hyg. A
260
523-538
1985
Candida albicans
Manually annotated by BRENDA team
Negi, M.; Tsuboi, R.; Matsui, T.; Ogawa, H.
Isolation and characterization of proteinase from Candida albicans: substrate specificity
J. Invest. Dermatol.
83
32-36
1984
Candida albicans
Manually annotated by BRENDA team
Skrbec, D.; Romeo, D.
Inhibition of Candida albicans secreted aspartic protease by a novel series of peptidomimetics, also active on the HIV-1 protease
Biochem. Biophys. Res. Commun.
297
1350-1353
2002
Candida albicans, Candida albicans H12
Manually annotated by BRENDA team
Pranav Kumar, S.K.; Kulkarni, V.M.
Insights into the selective inhibition of Candida albicans secreted aspartyl protease: a docking analysis study
Bioorg. Med. Chem.
10
1153-1170
2002
Candida albicans, Candida albicans (P0CS83)
Manually annotated by BRENDA team
Dostal, J.; Dlouha, H.; Malon, P.; Pichova, I.; Hruskova-Heidingsfeldova, O.
The precursor of secreted aspartic proteinase Sapp1p from Candida parapsilosis can be activated both autocatalytically and by a membrane-bound processing proteinase
Biol. Chem.
386
791-799
2005
Candida parapsilosis
Manually annotated by BRENDA team
Kalkanci, A.; Bozdayi, G.; Biri, A.; Kustimur, S.
Distribution of secreted aspartyl proteinases using a polymerase chain reaction assay with SAP specific primers in Candida albicans isolates
Folia Microbiol. (Praha)
50
409-413
2005
Candida albicans, Candida albicans (P0CY27), Candida albicans (P0CY29), Candida albicans (P0DJ06), Candida albicans (P43094), Candida albicans (Q5A8N2), Candida albicans (Q5AC08)
Manually annotated by BRENDA team
Foundling, S.I.
Candidapepsin
Handbook of proteolytic enzymes (Barrett, A. J. , Rawlings, N. D. , Woessner, J. F. , eds. ) Academic Press
1
115-120
2004
Candida albicans (P0CY27), Candida albicans (P0DJ06)
-
Manually annotated by BRENDA team
Vilanova, M.; Teixeira, L.; Caramalho, I.; Torrado, E.; Marques, A.; Madureira, P.; Ribeiro, A.; Ferreira, P.; Gama, M.; Demengeot, J.
Protection against systemic candidiasis in mice immunized with secreted aspartic proteinase 2
Immunology
111
334-342
2004
Candida albicans, Candida albicans (P0DJ06)
Manually annotated by BRENDA team
Taylor, B.N.; Staib, P.; Binder, A.; Biesemeier, A.; Sehnal, M.; Roellinghoff, M.; Morschhaeuser, J.; Schroeppel, K.
Profile of Candida albicans-secreted aspartic proteinase elicited during vaginal infection
Infect. Immun.
73
1828-1835
2005
Candida albicans
Manually annotated by BRENDA team
Schaller, M.; Korting, H.C.; Borelli, C.; Hamm, G.; Hube, B.
Candida albicans-secreted aspartic proteinases modify the epithelial cytokine response in an in vitro model of vaginal candidiasis
Infect. Immun.
73
2758-2765
2005
Candida albicans
Manually annotated by BRENDA team
Tavanti, A.; Pardini, G.; Campa, D.; Davini, P.; Lupetti, A.; Senesi, S.
Differential expression of secretory aspartyl proteinase genes (SAP1-10) in oral Candida albicans isolates with distinct karyotypes
J. Clin. Microbiol.
42
4726-4734
2004
Candida albicans
Manually annotated by BRENDA team
Staib, P.; Lermann, U.; Blass-Warmuth, J.; Degel, B.; Wuerzner, R.; Monod, M.; Schirmeister, T.; Morschhaeuser, J.
Tetracycline-inducible expression of individual secreted aspartic proteases in Candida albicans allows isoenzyme-specific inhibitor screening
Antimicrob. Agents Chemother.
52
146-156
2008
Candida albicans, Candida albicans (P0CY27), Candida albicans (P0CY29), Candida albicans (P0DJ06), Candida albicans (P43094), Candida albicans (Q59SU1), Candida albicans (Q59VH7), Candida albicans (Q5A8N2), Candida albicans (Q5AEM6)
Manually annotated by BRENDA team
Majer, F.; Pavlickova, L.; Majer, P.; Hradilek, M.; Dolejsi, E.; Hruskova-Heidingsfeldova, O.; Pichova, I.
Structure-based specificity mapping of secreted aspartic proteases of Candida parapsilosis, Candida albicans, and Candida tropicalis using peptidomimetic inhibitors and homology modeling
Biol. Chem.
387
1247-1254
2006
Candida albicans, Candida albicans (P0DJ06), Candida parapsilosis, Candida parapsilosis (P32951), Candida tropicalis, Candida tropicalis (Q00663)
Manually annotated by BRENDA team
Mendes, A.; Mores, A.U.; Carvalho, A.P.; Rosa, R.T.; Samaranayake, L.P.; Rosa, E.A.
Candida albicans biofilms produce more secreted aspartyl protease than the planktonic cells
Biol. Pharm. Bull.
30
1813-1815
2007
Candida albicans
Manually annotated by BRENDA team
Degel, B.; Staib, P.; Rohrer, S.; Scheiber, J.; Martina, E.; Buechold, C.; Baumann, K.; Morschhaeuser, J.; Schirmeister, T.
Cis-configured aziridines are new pseudo-irreversible dual-mode inhibitors of Candida albicans secreted aspartic protease 2
ChemMedChem
3
302-315
2008
Candida albicans, Candida albicans (P0DJ06)
Manually annotated by BRENDA team
Merkerova, M.; Dostal, J.; Hradilek, M.; Pichova, I.; Hruskova-Heidingsfeldova, O.
Cloning and characterization of Sapp2p, the second aspartic proteinase isoenzyme from Candida parapsilosis
FEMS Yeast Res.
6
1018-1026
2006
Candida parapsilosis, Candida parapsilosis (P32950), Candida parapsilosis CP386/IDE98 (P32950)
Manually annotated by BRENDA team
Jackson, B.E.; Wilhelmus, K.R.; Hube, B.
The role of secreted aspartyl proteinases in Candida albicans keratitis
Invest. Ophthalmol. Vis. Sci.
48
3559-3565
2007
Candida albicans, Candida albicans (P43095)
Manually annotated by BRENDA team
Barelle, C.J.; Duncan, V.M.; Brown, A.J.; Gow, N.A.; Odds, F.C.
Azole antifungals induce up-regulation of SAP4, SAP5 and SAP6 secreted proteinase genes in filamentous Candida albicans cells in vitro and in vivo
J. Antimicrob. Chemother.
61
315-322
2008
Candida albicans (P43094), Candida albicans (P43095), Candida albicans (Q5A8N2)
Manually annotated by BRENDA team
Borelli, C.; Ruge, E.; Lee, J.H.; Schaller, M.; Vogelsang, A.; Monod, M.; Korting, H.C.; Huber, R.; Maskos, K.
X-ray structures of Sap1 and Sap5: Structural comparison of the secreted aspartic proteinases from Candida albicans
Proteins
272
1308-1319
2008
Candida albicans (P0CY29)
Manually annotated by BRENDA team
Borelli, C.; Ruge, E.; Lee, J.H.; Schaller, M.; Vogelsang, A.; Monod, M.; Korting, H.C.; Huber, R.; Maskos, K.
X-ray structures of Sap1 and Sap5: Structural comparison of the secreted aspartic proteinases from Candida albicans
Proteins
72
1308-1319
2008
Candida albicans (P0CY27), Candida albicans (P43094)
Manually annotated by BRENDA team
Low, C.F.; Chong, P.P.; Yong, P.V.; Lim, C.S.; Ahmad, Z.; Othman, F.
Inhibition of hyphae formation and SIR2 expression in Candida albicans treated with fresh Allium sativum (garlic) extract
J. Appl. Microbiol.
105
2169-2177
2008
Candida albicans, Candida albicans (Q5A8N2)
Manually annotated by BRENDA team
Dabas, N.; Morschhaeuser, J.
A transcription factor regulatory cascade controls secreted aspartic protease expression in Candida albicans
Mol. Microbiol.
69
586-602
2008
Candida albicans, Candida albicans (P0DJ06)
Manually annotated by BRENDA team
Lee, S.A.; Jones, J.; Hardison, S.; Kot, J.; Khalique, Z.; Bernardo, S.M.; Lazzell, A.; Monteagudo, C.; Lopez-Ribot, J.
Candida albicans VPS4 is required for secretion of aspartyl proteases and in vivo virulence
Mycopathologia
167
55-63
2009
Candida albicans, Candida albicans (P43093), Candida albicans (P43094), Candida albicans (P43095)
Manually annotated by BRENDA team
Falkensammer, B.; Pleyer, L.; Ressler, S.; Berg, A.; Borg-von Zepelin, M.; Nagl, M.; Lass-Floerl, C.; Speth, C.; Dierich, M.P.; Wuerzner, R.
Basidiomycete metabolites attenuate virulence properties of Candida albicans in vitro
Mycoses
51
505-514
2008
Candida albicans, Candida albicans CBS 5982
Manually annotated by BRENDA team
Hruskova-Heidingsfeldova, O.; Dostal, J.; Majer, F.; Havlikova, J.; Hradilek, M.; Pichova, I.
Two aspartic proteinases secreted by the pathogenic yeast Candida parapsilosis differ in expression pattern and catalytic properties
Biol. Chem.
390
259-268
2009
Candida parapsilosis, Candida parapsilosis (P32950), Candida parapsilosis (P32951), Candida parapsilosis P-69 (P32950), Candida parapsilosis P-69 (P32951)
Manually annotated by BRENDA team
Braga-Silva, L.A.; Mesquita, D.G.; Ribeiro, M.D.; Carvalho, S.M.; Fracalanzza, S.E.; Santos, A.L.
Trailing end-point phenotype antibiotic-sensitive strains of Candida albicans produce different amounts of aspartyl peptidases
Braz. J. Med. Biol. Res.
42
765-770
2009
Candida albicans
Manually annotated by BRENDA team
Braga-Silva, L.A.; Mogami, S.S.; Valle, R.S.; Silva-Neto, I.D.; Santos, A.L.
Multiple effects of amprenavir against Candida albicans
FEMS Yeast Res.
10
221-224
2010
Candida albicans 11, Candida albicans
Manually annotated by BRENDA team
Trabocchi, A.; Mannino, C.; Machetti, F.; De Bernardis, F.; Arancia, S.; Cauda, R.; Cassone, A.; Guarna, A.
Identification of inhibitors of drug-resistant Candida albicans strains from a library of bicyclic peptidomimetic compounds
J. Med. Chem.
53
2502-2509
2010
Candida albicans
Manually annotated by BRENDA team
Paernaenen, P.; Meurman, J.H.; Samaranayake, L.; Virtanen, I.
Human oral keratinocyte E-cadherin degradation by Candida albicans and Candida glabrata
J. Oral Pathol. Med.
39
275-278
2010
Candida albicans, Candida glabrata
Manually annotated by BRENDA team
Dostal, J.; Brynda, J.; Hruskova-Heidingsfeldova, O.; Sieglova, I.; Pichova, I.; Rezacova, P.
The crystal structure of the secreted aspartic protease 1 from Candida parapsilosis in complex with pepstatin A
J. Struct. Biol.
167
145-152
2009
Candida parapsilosis, Candida parapsilosis P-69
Manually annotated by BRENDA team
Parra-Ortega, B.; Cruz-Torres, H.; Villa-Tanaca, L.; Hernandez-Rodriguez, C.
Phylogeny and evolution of the aspartyl protease family from clinically relevant Candida species
Mem. Inst. Oswaldo Cruz
104
505-512
2009
Candida albicans, Candida dubliniensis, Candida glabrata, Candida parapsilosis, Candida tropicalis, Clavispora lusitaniae, Kluyveromyces marxianus, Meyerozyma guilliermondii, Pichia kudriavzevii
Manually annotated by BRENDA team
Gropp, K.; Schild, L.; Schindler, S.; Hube, B.; Zipfel, P.F.; Skerka, C.
The yeast Candida albicans evades human complement attack by secretion of aspartic proteases
Mol. Immunol.
47
465-475
2009
Candida albicans
Manually annotated by BRENDA team
Hua, X.; Yuan, X.; Mitchell, B.M.; Lorenz, M.C.; ODay, D.M.; Wilhelmus, K.R.
Morphogenic and genetic differences between Candida albicans strains are associated with keratomycosis virulence
Mol. Vis.
15
1476-1484
2009
Candida albicans
Manually annotated by BRENDA team
Costa, C.R.; Jesuino, R.S.; de Aquino Lemos, J.; de Fatima Lisboa Fernandes, O.; Hasimoto e Souza, L.K.; Passos, X.S.; do Rosario Rodrigues Silva, M.
Effects of antifungal agents in Sap activity of Candida albicans isolates
Mycopathologia
169
91-98
2010
Candida albicans, Candida parapsilosis
Manually annotated by BRENDA team
Silva, S.; Hooper, S.J.; Henriques, M.; Oliveira, R.; Azeredo, J.; Williams, D.W.
The role of secreted aspartyl proteinases in Candida tropicalis invasion and damage of oral mucosa
Clin. Microbiol. Infect.
17
264-272
2011
Candida tropicalis
Manually annotated by BRENDA team
Sandini, S.; La Valle, R.; Deaglio, S.; Malavasi, F.; Cassone, A.; De Bernardis, F.
A highly immunogenic recombinant and truncated protein of the secreted aspartic proteases family (rSap2t) of Candida albicans as a mucosal anticandidal vaccine
FEMS Immunol. Med. Microbiol.
62
215-224
2011
Candida albicans, Candida albicans ATCC 20955
Manually annotated by BRENDA team
Correia, A.; Lermann, U.; Teixeira, L.; Cerca, F.; Botelho, S.; da Costa, R.M.; Sampaio, P.; Gaertner, F.; Morschhaeuser, J.; Vilanova, M.; Pais, C.
Limited role of secreted aspartyl proteinases Sap1 to Sap6 in Candida albicans virulence and host immune response in murine hematogenously disseminated candidiasis
Infect. Immun.
78
4839-4849
2010
Candida albicans
Manually annotated by BRENDA team
Aoki, W.; Kitahara, N.; Miura, N.; Morisaka, H.; Yamamoto, Y.; Kuroda, K.; Ueda, M.
Comprehensive characterization of secreted aspartic proteases encoded by a virulence gene family in Candida albicans
J. Biochem.
150
431-438
2011
Candida albicans, Candida albicans (P0CY27), Candida albicans (P0CY29), Candida albicans (P0DJ06), Candida albicans (P43094)
Manually annotated by BRENDA team
Vinterova, Z.; Sanda, M.; Dostal, J.; Hruskova-Heidingsfeldova, O.; Pichova, I.
Evidence for the presence of proteolytically active secreted aspartic proteinase 1 of Candida parapsilosis in the cell wall
Protein Sci.
20
2004-2012
2011
Candida parapsilosis
Manually annotated by BRENDA team