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Literature summary for 3.4.23.24 extracted from

  • Dostal, J.; Dlouha, H.; Malon, P.; Pichova, I.; Hruskova-Heidingsfeldova, O.
    The precursor of secreted aspartic proteinase Sapp1p from Candida parapsilosis can be activated both autocatalytically and by a membrane-bound processing proteinase (2005), Biol. Chem., 386, 791-799.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Candida parapsilosis

Inhibitors

Inhibitors Comment Organism Structure
isovaleryl-Val-Val-statyl-Ala-statyl-OH
-
Candida parapsilosis
tert-butoxycarbonyl-Val-Val-(3R,4R)-4-amino-3-hydroxy-5-phenylpentanoyl-Ala-phenylstatyl-O-methyl ester
-
Candida parapsilosis
tert-butoxycarbonyl-Val-Val-phenylstatyl-Ala-(3R,4R)-4-amino-3-hydroxy-5-phenylpentanoyl-OH
-
Candida parapsilosis
tert-butoxycarbonyl-Val-Val-phenylstatyl-Ala-O-methyl ester
-
Candida parapsilosis
tert-butoxycarbonyl-Val-Val-phenylstatyl-Ala-phenylstatyl-NH2
-
Candida parapsilosis
tert-butoxycarbonyl-Val-Val-phenylstatyl-Ala-phenylstatyl-O-methyl ester
-
Candida parapsilosis
tert-butoxycarbonyl-Val-Val-phenylstatyl-Ala-phenylstatyl-OH
-
Candida parapsilosis

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0092
-
Lys-Pro-Ala-Glu-Phe-4-nitrophenylalanine-Ala-Leu
-
Candida parapsilosis
0.0122
-
Ala-Thr-His-Gln-Val-Tyr-4-nitrophenylalanine-Val-Arg-Lys-Ala
-
Candida parapsilosis
0.0129
-
Lys-Pro-Leu-Glu-Met-4-nitrophenylalanine-Ala-Leu
-
Candida parapsilosis

Organism

Organism UniProt Comment Textmining
Candida parapsilosis
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification the Sapp1 precursor can be processed autocatalytically and by a membrane-bound processing proteinase. The pro-segment is indispensable for Sapp1p to attain an appropriate structure Candida parapsilosis

Purification (Commentary)

Purification (Comment) Organism
recombinant Candida parapsilosis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Ala-Thr-His-Gln-Val-Tyr-4-nitrophenylalanine-Val-Arg-Lys-Ala + H2O
-
Candida parapsilosis Ala-Thr-His-Gln-Val-Tyr + 4-nitrophenylalanine-Val-Arg-Lys-Ala
-
?
Lys-Pro-Ala-Glu-Phe-4-nitrophenylalanine-Ala-Leu + H2O
-
Candida parapsilosis Lys-Pro-Ala-Glu-Phe + 4-nitrophenylalanine-Ala-Leu
-
?
Lys-Pro-Leu-Glu-Met-4-nitrophenylalanine-Ala-Leu + H2O
-
Candida parapsilosis Lys-Pro-Leu-Glu-Met + 4-nitrophenylalanine-Ala-Leu
-
?

Synonyms

Synonyms Comment Organism
Sapp1p
-
Candida parapsilosis

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.41
-
Ala-Thr-His-Gln-Val-Tyr-4-nitrophenylalanine-Val-Arg-Lys-Ala
-
Candida parapsilosis
24.11
-
Lys-Pro-Leu-Glu-Met-4-nitrophenylalanine-Ala-Leu
-
Candida parapsilosis
31.8
-
Lys-Pro-Ala-Glu-Phe-4-nitrophenylalanine-Ala-Leu
-
Candida parapsilosis

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0000003
-
isovaleryl-Val-Val-statyl-Ala-statyl-OH
-
Candida parapsilosis
0.0000004
-
tert-butoxycarbonyl-Val-Val-phenylstatyl-Ala-phenylstatyl-O-methyl ester
-
Candida parapsilosis
0.0000009
-
tert-butoxycarbonyl-Val-Val-phenylstatyl-Ala-(3R,4R)-4-amino-3-hydroxy-5-phenylpentanoyl-OH
-
Candida parapsilosis
0.00000254
-
tert-butoxycarbonyl-Val-Val-phenylstatyl-Ala-phenylstatyl-NH2
-
Candida parapsilosis
0.0000065
-
tert-butoxycarbonyl-Val-Val-phenylstatyl-Ala-O-methyl ester
-
Candida parapsilosis
0.0000066
-
tert-butoxycarbonyl-Val-Val-phenylstatyl-Ala-phenylstatyl-OH
-
Candida parapsilosis
0.005301
-
tert-butoxycarbonyl-Val-Val-(3R,4R)-4-amino-3-hydroxy-5-phenylpentanoyl-Ala-phenylstatyl-O-methyl ester
-
Candida parapsilosis