3.4.23.20: Penicillopepsin

This is an abbreviated version, for detailed information about Penicillopepsin, go to the full flat file.

Reaction

Hydrolysis of proteins with broad specificity similar to that of pepsin A, preferring hydrophobic residues at P1 and P1', but also cleaving Gly20-/-Glu in the B chain of insulin. Clots milk, and activates trypsinogen =

Synonyms

Acid protease A, EC 3.4.23.6, EC 3.4.23.7, mold kinase, More, pencillopepsin-JT1, pencillopepsin-JT2, Penicillium citrinum acid proteinase, Penicillium cyclopium acid proteinase, Penicillium expansum acid proteinase, Penicillium janthinellum acid proteinase, Penicillium janthinellum aspartic proteinase, penicillium kinase, Penicillium roqueforti acid proteinase, penicillopepsin-JT1, penicillopepsin-JT2, penicillopepsin-JT3, Peptidase A, Proteinase, Penicillium aspartic, Proteinase, Penicillium caseicolum aspartic, Proteinase, Penicillium citrinum aspartic, Proteinase, Penicillium cyclopium acid, Proteinase, Penicillium duponti aspartic, Proteinase, Penicillium expansum aspartic, Proteinase, Penicillium janthinellum acid, Proteinase, Penicillium roqueforti aspartic

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.23 Aspartic endopeptidases
                3.4.23.20 Penicillopepsin

Inhibitors

Inhibitors on EC 3.4.23.20 - Penicillopepsin

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1,2-epoxy-3-(4-nitrophenoxy)propane
alpha-Diazo-p-bromoacetophenone
Penicillium duponti
-
in presence of Cu2+
Benzyloxycarbonyl-Gln-Tyr
-
-
Benzyloxycarbonyl-Glu
-
-
Benzyloxycarbonyl-Val-Tyr
-
-
Diazoacetyl DL-norleucine methyl ester
Diazoacetyl-DL-norleucine methyl ester
Diazoacetylglycine ethyl ester
Penicillium duponti
-
in presence of Cu2+
Difluorostatine- and difluorostatone-containing peptides
-
-
-
iodoacetic acid
-
-
isovaleryl-Val-statine-ethoxy
pepstatin analogue
isovaleryl-Val-Val-L-leucine phosphinic acid-L-3-phenyllactic acid methyl ester 1-L
-
-
-
isovaleryl-Val-Val-L-leucine phosphinic acid-L-3-phenyllactic acid methyl ester 2-L
-
-
-
isovaleryl-Val-Val-L-leucine phosphinic acid-L-3-phenyllactic acid methyl ester 3
-
-
-
Isovaleryl-Val-Val-statyl ethyl ester
-
-
Isovaleryl-Val-Val-statyl-Ala ethyl ester
-
-
K2PtCl6
-
partial
K3Fe(CN)6
-
-
KMnO4
Penicillium duponti
-
-
Leu-Gly-Leu
-
inhibits trypsinogen activation, activates cleavage of Leu-Tyr amide
methyl 10-hydroxy-6-[[N-(3-methylbutanoyl)valyl]amino]-9-(2-methylpropyl)-4,7-dioxo-11-oxa-3,8-diaza-10-phosphabicyclo[12.3.1]octadeca-1(18),14,16-triene-12-carboxylate 10-oxide
-
-
methyl cyclo[(2S)-2-[[(1R)-1-(N-(l-N-(3-methylbutanoyl)valyl-L-aspartyl)amino)-3-methylbutyl]hydroxyphosphinyloxy]-3-(3-aminomethyl)] phenylpropanoate
phosphonate-based macrocycle PPi4, macrocyclic pentapeptide inhibitor
-
methyl cyclo[(2S)-2-[[(1R)-1-(N-(l-N-(3-methylbutanoyl)valyl-L-aspartyl)amino)-3-methylbutyl]ydroxyphosphinyloxy]-3-(3-aminomethyl)] phenylpropanoate
-
N-bromosuccinimide
Penicillium duponti
-
-
Phosphorus-based peptide analogues
-
-
-
sodium lauryl sulfate
Penicillium duponti
-
-
Specific pepsin inhibitor produced by Streptomyces naniwaensis
Penicillium duponti
-
-
-
Streptomycin inhibitor
-
weak
-
additional information
-