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3.4.23.20: Penicillopepsin

This is an abbreviated version!
For detailed information about Penicillopepsin, go to the full flat file.

Word Map on EC 3.4.23.20

Reaction

Hydrolysis of proteins with broad specificity similar to that of pepsin A, preferring hydrophobic residues at P1 and P1', but also cleaving Gly20-/-Glu in the B chain of insulin. Clots milk, and activates trypsinogen =

Synonyms

Acid protease A, EC 3.4.23.6, EC 3.4.23.7, EC 3.4.4.17, mold kinase, More, pencillopepsin-JT1, pencillopepsin-JT2, Penicillium citrinum acid proteinase, Penicillium cyclopium acid proteinase, Penicillium expansum acid proteinase, Penicillium janthinellum acid proteinase, Penicillium janthinellum aspartic proteinase, penicillium kinase, Penicillium roqueforti acid proteinase, penicillopepsin-JT1, penicillopepsin-JT2, penicillopepsin-JT3, PEP, PepA, Peptidase A, Proteinase, Penicillium aspartic, Proteinase, Penicillium caseicolum aspartic, Proteinase, Penicillium citrinum aspartic, Proteinase, Penicillium cyclopium acid, Proteinase, Penicillium duponti aspartic, Proteinase, Penicillium expansum aspartic, Proteinase, Penicillium janthinellum acid, Proteinase, Penicillium roqueforti aspartic

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.23 Aspartic endopeptidases
                3.4.23.20 Penicillopepsin

Inhibitors

Inhibitors on EC 3.4.23.20 - Penicillopepsin

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1,2-epoxy-3-(4-nitrophenoxy)propane
2-mercaptoethanol
-
10.55% inhibition at 10 mM
alpha-Diazo-p-bromoacetophenone
Penicillium duponti
-
in presence of Cu2+
Benzyloxycarbonyl-Gln-Tyr
-
-
Benzyloxycarbonyl-Glu
-
-
Benzyloxycarbonyl-Val-Tyr
-
-
Ca2+
Penicillium candidum
-
23% residual activity at 10 mM
Diazoacetyl DL-norleucine methyl ester
Diazoacetyl-DL-norleucine methyl ester
Diazoacetylglycine ethyl ester
Penicillium duponti
-
in presence of Cu2+
Difluorostatine- and difluorostatone-containing peptides
-
-
-
EDTA
Penicillium candidum
-
7% residual activity at 10 mM
Fe3+
Penicillium candidum
-
complete inhibition at 10 mM
iodoacetic acid
-
-
isovaleryl-Val-statine-ethoxy
pepstatin analogue
Isovaleryl-Val-Val-statyl ethyl ester
-
-
Isovaleryl-Val-Val-statyl-Ala ethyl ester
-
-
K+
Penicillium candidum
-
85% residual activity at 10 mM
K2PtCl6
-
partial
K3Fe(CN)6
-
-
KMnO4
Penicillium duponti
-
-
Leu-Gly-Leu
-
inhibits trypsinogen activation, activates cleavage of Leu-Tyr amide
methyl (2S)-2-({hydroxy[({N-[(naphthalen-1-yl)acetyl]-L-valyl}amino)methyl]phosphoryl}oxy)-3-phenylpropanoate
-
-
methyl (2S)-2-({[(4S,7R)-2,5-dioxo-4-(propan-2-yl)-2,3,4,5,6,7-hexahydro-1H-8,10-etheno-3,6-benzodiazacycloundecin-7-yl](hydroxy)phosphoryl}oxy)-3-phenylpropanoate
-
-
methyl (2S)-2-({[(R)-[(N-formyl-L-valyl)amino](naphthalen-2-yl)methyl](hydroxy)phosphoryl}oxy)-3-phenylpropanoate
-
-
methyl 10-hydroxy-6-[[N-(3-methylbutanoyl)valyl]amino]-9-(2-methylpropyl)-4,7-dioxo-11-oxa-3,8-diaza-10-phosphabicyclo[12.3.1]octadeca-1(18),14,16-triene-12-carboxylate 10-oxide
methyl cyclo[(2S)-2-[[(1R)-1-(N-(l-N-(3-methylbutanoyl)valyl-L-aspartyl)amino)-3-methylbutyl]hydroxyphosphinyloxy]-3-(3-aminomethyl)] phenylpropanoate
phosphonate-based macrocycle PPi4, macrocyclic pentapeptide inhibitor
methyl cyclo[(2S)-2-[[(1R)-1-(N-(l-N-(3-methylbutanoyl)valyl-L-aspartyl)amino)-3-methylbutyl]ydroxyphosphinyloxy]-3-(3-aminomethyl)] phenylpropanoate
-
Mg2+
Penicillium candidum
-
31% residual activity at 10 mM
Mn2+
Penicillium candidum
-
98% residual activity at 10 mM
N-(3-methylbutanoyl)valyl-N1-(1-[hydroxy[(1-methoxy-1-oxo-3-phenylpropan-2-yl)oxy]phosphoryl]-3-methylbutyl)aspartamide
-
N-bromosuccinimide
Penicillium duponti
-
-
pepstatin A
-
55.08% inhibition at 10 mM
phenylmethylsulfonyl fluoride
-
complete inhibition at 10 mM
Phosphorus-based peptide analogues
-
-
-
SDS
Penicillium candidum
-
33% residual activity at 10 mM
sodium lauryl sulfate
Penicillium duponti
-
-
Specific pepsin inhibitor produced by Streptomyces naniwaensis
Penicillium duponti
-
-
-
Streptomycin inhibitor
-
weak
-
Zn2+
Penicillium candidum
-
92% residual activity at 10 mM
additional information
-