3.4.23.20: Penicillopepsin

This is an abbreviated version, for detailed information about Penicillopepsin, go to the full flat file.

Reaction

Hydrolysis of proteins with broad specificity similar to that of pepsin A, preferring hydrophobic residues at P1 and P1', but also cleaving Gly20-/-Glu in the B chain of insulin. Clots milk, and activates trypsinogen =

Synonyms

Acid protease A, EC 3.4.23.6, EC 3.4.23.7, mold kinase, More, pencillopepsin-JT1, pencillopepsin-JT2, Penicillium citrinum acid proteinase, Penicillium cyclopium acid proteinase, Penicillium expansum acid proteinase, Penicillium janthinellum acid proteinase, Penicillium janthinellum aspartic proteinase, penicillium kinase, Penicillium roqueforti acid proteinase, penicillopepsin-JT1, penicillopepsin-JT2, penicillopepsin-JT3, Peptidase A, Proteinase, Penicillium aspartic, Proteinase, Penicillium caseicolum aspartic, Proteinase, Penicillium citrinum aspartic, Proteinase, Penicillium cyclopium acid, Proteinase, Penicillium duponti aspartic, Proteinase, Penicillium expansum aspartic, Proteinase, Penicillium janthinellum acid, Proteinase, Penicillium roqueforti aspartic

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.23 Aspartic endopeptidases
                3.4.23.20 Penicillopepsin

Crystallization

Crystallization on EC 3.4.23.20 - Penicillopepsin

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Crystallization/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
crystal structure at: 1.8 A
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crystal structure in complex with inhibitor PPi3, monoclinic space group C2, a : 96.24 A, b : 46.47 A, c : 65.38 A, crystal structure in complex with inhibitor PPi4, monoclinic space group C2, a : 96.98 A, b : 46.65 A, c : 65.71 A
crystal structure of native penicillopepsin and of its complex with a synthetic analogue of the inhibitor pepstatin at 1.8 A resolution
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crystallographic analysis of transition state mimics bound to penicillopepsin; difluorostatine- and difluorostatone-containing peptides
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crystallographic analysis of transition state mimics bound to penicillopepsin; phosphorus-containing peptide analogues
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purified penicillopepsin-JT1, free or bound to difluorostatine- and difluorostatone-containing peptides, X-ray diffraction structure determination and analysis at 0.95-2.8 A resolution
cocrystallized with inhibitor 1-L, space group C2, cell dimensions a 0 97.88 A, b = 46.64 A, c = 66.59 A
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