3.4.23.16: HIV-1 retropepsin
This is an abbreviated version!
For detailed information about HIV-1 retropepsin, go to the full flat file.
Word Map on EC 3.4.23.16
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3.4.23.16
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antiretroviral
-
ritonavir
-
transcriptase
-
saquinavir
-
indinavir
-
nelfinavir
-
hiv-infected
-
lopinavir
-
polyproteins
-
flap
-
darunavir
-
amprenavir
-
drug-resistant
-
anti-hiv
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atazanavir
-
virological
-
haart
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gag-pol
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peptidomimetic
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virion
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p-glycoprotein
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lipodystrophy
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non-nucleoside
-
integrase
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cross-resistance
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isostere
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nonpeptidic
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zidovudine
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nevirapine
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virus-1
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tipranavir
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cyp3a4
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nnrti
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drug-drug
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treatment-experienced
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lamivudine
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didanosine
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ritonavir-boosted
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autoprocessing
-
efavirenz
-
protease-inhibitor
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stavudine
-
treatment-naive
-
analysis
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raltegravir
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zalcitabine
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plasmepsins
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antiretroviral-naive
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pi-based
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pharmacology
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drug development
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medicine
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hiv-rna
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lipoatrophy
- 3.4.23.16
-
antiretroviral
- ritonavir
- transcriptase
- saquinavir
- indinavir
- nelfinavir
-
hiv-infected
- lopinavir
- polyproteins
- flap
- darunavir
- amprenavir
-
drug-resistant
-
anti-hiv
- atazanavir
-
virological
-
haart
- gag-pol
-
peptidomimetic
- virion
- p-glycoprotein
- lipodystrophy
-
non-nucleoside
-
integrase
-
cross-resistance
- isostere
-
nonpeptidic
- zidovudine
- nevirapine
- virus-1
- tipranavir
- cyp3a4
-
nnrti
-
drug-drug
-
treatment-experienced
- lamivudine
- didanosine
-
ritonavir-boosted
-
autoprocessing
- efavirenz
-
protease-inhibitor
- stavudine
-
treatment-naive
- analysis
- raltegravir
- zalcitabine
-
plasmepsins
-
antiretroviral-naive
-
pi-based
- pharmacology
- drug development
- medicine
-
hiv-rna
-
lipoatrophy
Reaction
specific for a P1 residue that is hydrophobic, and P1' variable, but often Pro =
Synonyms
CRF01_AE protease, Gag protease, HIV aspartyl protease, HIV PR, HIV protease, HIV-1 aspartyl protease, HIV-1 PR, HIV-1 protease, HIV-1 proteinase, HIV-1PR, HIV-2 protease, HIVPR, human immunodeficiency virus 1 protease, human immunodeficiency virus 1 retropepsin, human immunodeficiency virus protease, human immunodeficiency virus type 1 protease, human immunodeficiency virus type I protease, More, PR, PR1, PR2, retropepsin, retroproteinase
ECTree
3.4.23.16 HIV-1 retropepsinAdvanced search results
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results (Turnover Number
Turnover Number on EC 3.4.23.16 - HIV-1 retropepsin
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TURNOVER NUMBER [1/s] 
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
1.1
Abz-Thr-Ile-Nle-Phe(NO2)-Gln-Arg
-
mutant I50V, pH 5.6, 26°C
2.23
Abz-Thr-Ile-Nle-Phe(NO2)-Gln-Arg
-
mutant I54V, pH 5.6, 26°C
3.2
Abz-Thr-Ile-Nle-Phe(NO2)-Gln-Arg
-
wild-type, pH 5.6, 26°C
3.67
Abz-Thr-Ile-Nle-Phe(NO2)-Gln-Arg
-
mutant G48V, pH 5.6, 26°C
5
Abz-Thr-Ile-Nle-Phe(NO2)-Gln-Arg
-
mutant I54M, pH 5.6, 26°C
0.0008
AETFYVDGAA
pH 5.6, 37°C, autolysis reistant and truncated enzyme form PR-(5-99) with mutation Q7K/L33I/L63I/C67A/C95A
0.41
AETFYVDGAA
pH 5.6, 37°C, autolysis resistant enzyme form PR with the mutations Q7K/L33I/L63I/C67A/C95A
0.05
CTLNFPISP
pH 5.6, 37°C, autolysis reistant and truncated enzyme form PR-(5-99) with mutation Q7K/L33I/L63I/C67A/C95A
1.72
CTLNFPISP
pH 5.6, 37°C, autolysis resistant enzyme form PR with the mutations Q7K/L33I/L63I/C67A/C95A
0.3
IPFAAAQQRK
wild type enzyme, in 0.5 M potassium phosphate buffer, pH 5.6, containing 10% (v/v) glycerol, 2 mM EDTA, 10 mM dithiothreitol, 4 M NaCl, at 37°C
1.2
IPFAAAQQRK
mutant enzyme V32I/I47V/V82I, in 0.5 M potassium phosphate buffer, pH 5.6, containing 10% (v/v) glycerol, 2 mM EDTA, 10 mM dithiothreitol, 4 M NaCl, at 37°C
0.08
IRKILFLDG
pH 5.6, 37°C, autolysis reistant and truncated enzyme form PR-(5-99) with mutation Q7K/L33I/L63I/C67A/C95A
1.2
IRKILFLDG
pH 5.6, 37°C, autolysis resistant enzyme form PR with the mutations Q7K/L33I/L63I/C67A/C95A
0.3
KARLMAEALK
wild type enzyme, in 0.5 M potassium phosphate buffer, pH 5.6, containing 10% (v/v) glycerol, 2 mM EDTA, 10 mM dithiothreitol, 4 M NaCl, at 37°C
0.6
KARLMAEALK
mutant enzyme V32I/I47V/V82I, in 0.5 M potassium phosphate buffer, pH 5.6, containing 10% (v/v) glycerol, 2 mM EDTA, 10 mM dithiothreitol, 4 M NaCl, at 37°C
0.767
KARV-Nle-Phe(NO2)-EA-Nle
-
pH 5.0, mutant enzyme Q7K/L33I/L63I/C67A/C95A
0.44
KARV-Nle-Phe(NO2)-EA-Nle-NH2
-
pH 5.0, 25°C, truncated version PR-(5-99) from mutant enzyme Q7K/L33I/L63I/C67A/C95A
1.9
KARV-Nle-Phe(NO2)-EA-Nle-NH2
-
pH 5.0, 25°C, wild-type enzyme
3.5
KARV-Nle-Phe(NO2)-EA-Nle-NH2
-
pH 5.0, 25°C, mutant enzyme C67A/C95A and mutant enzyme C95A
3.7
KARV-Nle-Phe(NO2)-EA-Nle-NH2
-
pH 5.0, 25°C, mutant enzyme C67A
3.74
KARV-Nle-Phe(NO2)-EA-Nle-NH2
-
pH 5.0, 25°C, wild-type enzyme
5.2
KARV-Nle-Phe(NO2)-EA-Nle-NH2
-
pH 5.0, 25°C, mutant enzyme Q7K/R8Q/L33I/L63I/C67A/C95A
5.5
KARV-Nle-Phe(NO2)-EA-Nle-NH2
-
pH 5.0, 25°C, mutant enzyme Q7K/L33I/L63I/C67A/C95A
0.11
KARVLAEAMS
pH 5.6, 37°C, autolysis reistant and truncated enzyme form PR-(5-99) with mutation Q7K/L33I/L63I/C67A/C95A
0.89
KARVLAEAMS
pH 5.6, 37°C, autolysis resistant enzyme form PR with the mutations Q7K/L33I/L63I/C67A/C95A
61
Lys-Ala-Arg-Val-Nle-4-nitro-Phe-Glu-Ala-Nle-amide
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pH 5.0, 25°C, mutant L24I
194.5
Lys-Ala-Arg-Val-Nle-4-nitro-Phe-Glu-Ala-Nle-amide
-
pH 5.0, mutant V82A
280
Lys-Ala-Arg-Val-Nle-4-nitro-Phe-Glu-Ala-Nle-amide
-
pH 5.0, 25°C, mutant G73S
285
Lys-Ala-Arg-Val-Nle-4-nitro-Phe-Glu-Ala-Nle-amide
-
pH 5.0, mutant Q7K/L33I/L63I/C67A/C95A
480
Lys-Ala-Arg-Val-Nle-4-nitro-Phe-Glu-Ala-Nle-amide
-
pH 5.0, 25°C, mutant I50V
780
Lys-Ala-Arg-Val-Nle-4-nitro-Phe-Glu-Ala-Nle-amide
-
pH 5.0, mutant I84V
3.2
Lys-Ala-Arg-Val-Nle-Phe(4-NO2)-Glu-Ala-Nle-Gly
-
37°C, pH 4.7, HIV-1 subtype B protease D30N/N88D
3.5
Lys-Ala-Arg-Val-Nle-Phe(4-NO2)-Glu-Ala-Nle-Gly
-
37°C, pH 4.7, HIV-1 subtype B protease mutant D30M/L90M
4
Lys-Ala-Arg-Val-Nle-Phe(4-NO2)-Glu-Ala-Nle-Gly
-
37°C, pH 4.7, HIV-1 subtype B protease D30N/L90M
4.3
Lys-Ala-Arg-Val-Nle-Phe(4-NO2)-Glu-Ala-Nle-Gly
-
37°C, pH 4.7, HIV-1 subtype B protease mutant N88D
4.8
Lys-Ala-Arg-Val-Nle-Phe(4-NO2)-Glu-Ala-Nle-Gly
-
37°C, pH 4.7, HIV-1 subtype B protease mutant L90M
5
Lys-Ala-Arg-Val-Nle-Phe(4-NO2)-Glu-Ala-Nle-Gly
-
37°C, pH 4.7, HIV-1 subtype B protease mutant D30N
5.6
Lys-Ala-Arg-Val-Nle-Phe(4-NO2)-Glu-Ala-Nle-Gly
-
37°C, pH 4.7, HIV-1 subtype C protease
5.8
Lys-Ala-Arg-Val-Nle-Phe(4-NO2)-Glu-Ala-Nle-Gly
-
37°C, pH 4.7, HIV-1 subtype B protease mutant L90M
10
Lys-Ala-Arg-Val-Nle-Phe(4-NO2)-Glu-Ala-Nle-Gly
-
37°C, pH 4.7, HIV-1 subtype B protease
10.2
Lys-Ala-Arg-Val-Nle-Phe(4-NO2)-Glu-Ala-Nle-Gly
-
37°C, pH 4.7, HIV-1 subtype B protease N88D/L90M
12
Lys-Ala-Arg-Val-Nle-Phe(4-NO2)-Glu-Ala-Nle-Gly
-
37°C, pH 4.7, HIV-1 subtype B protease mutant N88D
12
Lys-Ala-Arg-Val-Nle-Phe(4-NO2)-Glu-Ala-Nle-Gly
-
37°C, pH 4.7, HIV-1 subtype C protease mutant D30N
12.4
Lys-Ala-Arg-Val-Nle-Phe(4-NO2)-Glu-Ala-Nle-Gly
-
37°C, pH 4.7, HIV-1 subtype B protease mutant D30N/N88D
13
Lys-Ala-Arg-Val-Nle-Phe(4-NO2)-Glu-Ala-Nle-Gly
-
37°C, pH 4.7, HIV-1 subtype B protease N88D/L90M
8
Lys-Ala-Arg-Val-Nle-Phe(4-NO2)-Glu-Ala-Nle-NH2
-
37°C, pH 4.7, mutant enzyme N88D
12
Lys-Ala-Arg-Val-Nle-Phe(4-NO2)-Glu-Ala-Nle-NH2
-
37°C, pH 4.7, mutant enzyme A71V
14
Lys-Ala-Arg-Val-Nle-Phe(4-NO2)-Glu-Ala-Nle-NH2
-
37°C, pH 4.7, mutant enzyme D30N/A71V
16
Lys-Ala-Arg-Val-Nle-Phe(4-NO2)-Glu-Ala-Nle-NH2
-
37°C, pH 4.7, mutant enzyme D30N/L63PA71V/L90M
16
Lys-Ala-Arg-Val-Nle-Phe(4-NO2)-Glu-Ala-Nle-NH2
-
37°C, pH 4.7, mutant enzyme L90M
17
Lys-Ala-Arg-Val-Nle-Phe(4-NO2)-Glu-Ala-Nle-NH2
-
37°C, pH 4.7, mutant enzyme D30N
22
Lys-Ala-Arg-Val-Nle-Phe(4-NO2)-Glu-Ala-Nle-NH2
-
37°C, pH 4.7, mutant enzyme D30N/L90M
24
Lys-Ala-Arg-Val-Nle-Phe(4-NO2)-Glu-Ala-Nle-NH2
-
37°C, pH 4.7, mutant enzyme D30N/N88D
30
Lys-Ala-Arg-Val-Nle-Phe(4-NO2)-Glu-Ala-Nle-NH2
-
37°C, pH 4.7, wild-type enzyme
0.0267
REYDQIIIEVS
-
pH 5.5, 30°C, mutant enzyme Q7K/L33I/L63I
62.7
RQGTVSFNFPQITL
-
pH 5.0, 37°C, wild-type enzyme
0.06
VLQNYPIVQ
wild type enzyme, in 0.5 M potassium phosphate buffer, pH 5.6, containing 10% (v/v) glycerol, 2 mM EDTA, 10 mM dithiothreitol, 4 M NaCl, at 37°C
0.26
VLQNYPIVQ
mutant enzyme V32I/I47V/V82I, in 0.5 M potassium phosphate buffer, pH 5.6, containing 10% (v/v) glycerol, 2 mM EDTA, 10 mM dithiothreitol, 4 M NaCl, at 37°C
0.4
VSQLYPIVQ
wild type enzyme, in 0.5 M potassium phosphate buffer, pH 5.6, containing 10% (v/v) glycerol, 2 mM EDTA, 10 mM dithiothreitol, 4 M NaCl, at 37°C
5.1
VSQLYPIVQ
mutant enzyme V32I/I47V/V82I, in 0.5 M potassium phosphate buffer, pH 5.6, containing 10% (v/v) glycerol, 2 mM EDTA, 10 mM dithiothreitol, 4 M NaCl, at 37°C
2.6
VSQVYPIVQ
wild type enzyme, in 0.5 M potassium phosphate buffer, pH 5.6, containing 10% (v/v) glycerol, 2 mM EDTA, 10 mM dithiothreitol, 4 M NaCl, at 37°C
3
VSQVYPIVQ
mutant enzyme V32I/I47V/V82I, in 0.5 M potassium phosphate buffer, pH 5.6, containing 10% (v/v) glycerol, 2 mM EDTA, 10 mM dithiothreitol, 4 M NaCl, at 37°C
0.16
VVQNYPIVQ
wild type enzyme, in 0.5 M potassium phosphate buffer, pH 5.6, containing 10% (v/v) glycerol, 2 mM EDTA, 10 mM dithiothreitol, 4 M NaCl, at 37°C
0.18
VVQNYPIVQ
mutant enzyme V32I/I47V/V82I, in 0.5 M potassium phosphate buffer, pH 5.6, containing 10% (v/v) glycerol, 2 mM EDTA, 10 mM dithiothreitol, 4 M NaCl, at 37°C
