Reference on EC 3.4.23.16 - HIV-1 retropepsin
Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Rose, R.B.; Craik, C.S.; Douglas, N.L.; Stroud, R.M.
Three-dimensional structures of HIV-1 and SIV protease product complexes
Biochemistry
35
12933-12944
1996
Human immunodeficiency virus 1 (P03369)
Miller, M.; Schneider, J.; Sathyanarayana, B.K.; Toth, M.V.; Marshall, G.R.; Clawson, L.; Selk, L.; Kent, S.B.H.; Wlodawer, A.
Structure of complex of synthetic HIV-1 protease with a substrate-based inhibitor at 2.3 A resolution
Science
246
1149-1152
1989
Human immunodeficiency virus 1
Stebbins, J.; Debouck, C.
Expression systems for retroviral proteases
Methods Enzymol.
241
3-16
1994
Human immunodeficiency virus 1
Hellen, C.U.T.
Assay methods for retroviral proteases
Methods Enzymol.
241
46-58
1994
Human immunodeficiency virus 1
von der Helm, K.; Seelmeier, S.; Kisselev, A.; Nitschko, H.
Identification, purification, and cell culture assays of retroviral proteases
Methods Enzymol.
241
89-104
1994
Human immunodeficiency virus 1
Meek, T.D.; Rodriguez, E.J.; Angeles, T.S.
Use of steady state kinetic methods to elucidate the kinetic and chemical mechanisms of retroviral proteases
Methods Enzymol.
241
127-156
1994
Human immunodeficiency virus 1
Ringe, D.
X-ray structures of retroviral proteases and their inhibitor-bound complexes
Methods Enzymol.
241
157-177
1994
Human immunodeficiency virus 1
Lin, X.L.; Lin, Y.Z.; Tang, J.
Relationships of human immunodeficiency virus protease with eukaryotic aspartic proteases
Methods Enzymol.
241
195-224
1994
Human immunodeficiency virus 1
Tomasselli, A.G.; Heinrikson, R.L.
Specificity of retroviral proteases: an analysis of viral and nonviral protein substrates
Methods Enzymol.
241
279-301
1994
Human immunodeficiency virus 1
Vacca, J.P.
Design of tight-binding inhibitors
Methods Enzymol.
241
311-334
1994
Human immunodeficiency virus 1
Schramm, H.J.; Billich, A.; Jaeger, E.; Rucknagel, K.P.; Arnold, G.; Schramm, W.
The inhibition of HIV-1 protease by interface peptides
Biochem. Biophys. Res. Commun.
194
595-600
1993
Human immunodeficiency virus 1
Athauda, S.B.P.; Ido, E.; Arakawa, H.; Nishigai, M.; Kyushiki, H.; Yoshinaka, Y.; Takahashi, T.; Ikai, A.; Tang, J.; Takahashi, K.
Entrapment and inhibition of human immunodeficiency virus proteinase by alpha 2-macroglobulin and structural changes in the inhibitor
J. Biochem.
113
742-746
1993
Human immunodeficiency virus 1
Friedman, S.H.; DeCamp, D.L.; Sijbesma, R.P.; Srdanov, G.; Wudl, F.; Kenyon, G.L.
Inhibition of the HIV-1 protease by fullerene derivatives: model building studies and experimental verification
J. Am. Chem. Soc.
115
6506-6509
1993
Human immunodeficiency virus 1
-
Blundell, T.L.; Lapatto, R.; Wilderspin, A.F.; Hemmings, A.M.; Hobart, P.M.; Danley, D.E.; Whittle, P.J.
The 3-D structure of HIV-1 proteinase and the design of antiviral agents for the treatment of AIDS
Trends Biochem. Sci.
15
425-430
1990
Human immunodeficiency virus 1
Hui, J.O.; Tomasselli, A.G.; Reardon, I.M.; Lull, J.M.; Brunner, D.P.; Tomich, C.S.C.; Heinrikson, R.L.
Large scale purification and refolding of HIV-1 protease from Escherichia coli inclusion bodies
J. Protein Chem.
12
323-327
1993
Human immunodeficiency virus 1
Yamazaki, T.; Nicholson, L.K.; Torchia, D.A.; Wingfield, P.; Stahl, S.J.; Kaufman, J.D.; Eyerman, C.J.; Hodge, C.N.; Lam, P.Y.S.; Ru, Y.; Jadhav, P.K.; Chang, C.H.; Weber, P.C.
NMR and X-Ray evidence that the HIV protease catalytic aspartyl groups have an essential role in the complex formed by the protease and a non-peptide cyclic urea-based inhibitor
J. Am. Chem. Soc.
116
10791-10792
1994
Human immunodeficiency virus 1
-
Kim, D.H.; Lee, J.; Sung, Y.C.; Choi, K.Y.
Expression and purification of HIV-1 protease utilizing a maltose binding protein
Mol. Cells
4
79-84
1994
Human immunodeficiency virus 1
-
Mildner, A.M.; Rothrock, D.J.; Leone, J.W.; Bannow, C.A.; Lull, J.M.; Reardon, I.M.; Sarcich, J.L.; Howe, W.J.; Tomich, C.S.C.; Smith, C.W.; Heinrikson, R.L.; Tomasselli, A.G.
The HIV-1 protease as enzyme and substrate: mutagenesis of autolysis sites and generation of a stable mutant with retained kinetic properties
Biochemistry
33
9405-9413
1994
Human immunodeficiency virus 1
Beck, Z.Q.; Morris, G.M.; Elder, J.H.
Defining HIV-1 protease substrate selectivity
Curr. Drug Targets Infect. Disord.
2
37-50
2002
Human immunodeficiency virus 1
Ridky, T.W.; Kikonyogo, A.; Leis, J.; Gulnik, S.; Copeland, T.; Erickson, J.; Wlodawer, A.; Kurinov, I.; Harrison, R.W.; Weber, I.T.
Drug-resistant HIV-1 proteases identify enzyme residues important for substrate selection and catalytic rate
Biochemistry
37
13835-13845
1998
Human immunodeficiency virus 1
Swairjo, M.A.; Towler, E.M.; Debouck, C.; Abdel-Meguid, S.S.
Structural role of the 30's loop in determining the ligand specificity of the human immunodeficiency virus Protease
Biochemistry
37
10928-10936
1998
Human immunodeficiency virus 1
Komai, T.; Yagi, R.; Suzuki-Sunagawa, H.; Ishikawa, Y.; Kasuya, A.; Miyamoto, S.; Handa, H.; Nishigaki, T.
Inhibition of HIV-1 protease by oxim derivatives
Biochem. Biophys. Res. Commun.
230
557-561
1997
Human immunodeficiency virus 1
Louis, J.M.; Dyda, F.; Nashed, N.T.; Kimmel, A.R.; Davies, D.R.
Hydrophilic peptides derived from the transframe region of Gag-Pol inhibit the HIV-1 protease
Biochemistry
37
2105-2110
1998
Human immunodeficiency virus 1
Ermolieff, J.; Lin, X.; Tang, J.
Kinetic properties of saquinavir-resistant mutants of human immunodeficiency virus type 1 protease and their implications in drug resistance in vivo
Biochemistry
36
12364-12370
1997
Human immunodeficiency virus 1
Davis, D.A.; Dorsey, K.; Wingfield, P.T.; Stahl, S.J.; Kaufman, J.; Fales, H.M.; Levine, R.L.
Regulation of HIV-1 protease activity through cysteine modification
Biochemistry
35
2482-2488
1996
Human immunodeficiency virus 1, Human immunodeficiency virus 1 HXB2
Haneda, E.; Furuya, T.; Asai, S.; Morikawa, Y.; Ohtsuki, K.
Biochemical characterization of casein kinase II as a protein kinase responsible for stimulation of HIV-1 protease in vitro
Biochem. Biophys. Res. Commun.
275
434-439
2000
Human immunodeficiency virus 1
Todd, M.J.; Semo, N.; Freire, E.
The structural stability of the HIV-1 protease
J. Mol. Biol.
283
475-488
1998
Human immunodeficiency virus 1
Silva, A.M.; Cachau, R.E.; Sham, H.L.; Erickson, J.W.
Inhibition and catalytic mechanism of HIV-1 aspartic protease
J. Mol. Biol.
255
321-346
1996
Human immunodeficiency virus 1
Hong, L.; Zhang, C.; Hartsuck, J.A.; Foundling, S.; Tang, J.
X-ray crystallographic studies of the structure-function relationships of HIV-1 protease
Adv. Exp. Med. Biol.
436
59-63
1998
Human immunodeficiency virus 1
Ermolieff, J.; Lin, X.; Tang, J.
The effect of substrates on the kinetics and the in vivo threshold activity of mutant HIV-1 proteases
Adv. Exp. Med. Biol.
436
47-51
1998
Human immunodeficiency virus 1
Grobelny, D.; Chen, Q.; Tyssen, D.; Tachedjian, G.; Sebire, K.; Buchanan, L.; Birch, C.
Antiviral activity of DG-35-VII, a potent inhibitor of the protease of human immunodeficiency virus
Antiviral Chem. Chemother.
8
99-106
1997
Human immunodeficiency virus 1
-
Short, G.F., 3rd; Laikhter, A.L.; Lodder, M.; Shayo, Y.; Arslan, T.; Hecht, S.M.
Probing the S1/S1' substrate binding pocket geometry of HIV-1 protease with modified aspartic acid analogues
Biochemistry
39
8768-8781
2000
Human immunodeficiency virus 1
Porter, D.J.; Hanlon, M.H.; Furfine, E.S.
HIV-1 protease: characterization of a catalytically competent enzyme-substrate intermediate
Biochemistry
41
1302-1307
2002
Human immunodeficiency virus 1
Tossi, A.; Benedetti, F.; Norbedo, S.; Skrbec, D.; Berti, F.; Romeo, D.
Small hydroxyethylene-based peptidomimetics inhibiting both HIV-1 and C. albicans aspartic proteases
Bioorg. Med. Chem.
11
4719-4727
2003
Human immunodeficiency virus 1
Mahalingam, B.; Louis, J.M.; Reed, C.C.; Adomat, J.M.; Krouse, J.; Wang, Y.F.; Harrison, R.W.; Weber, I.T.
Structural and kinetic analysis of drug resistant mutants of HIV-1 protease
Eur. J. Biochem.
263
238-245
1999
Human immunodeficiency virus 1
Kumar, M.; Hosur, M.V.
Adaptability and flexibility of HIV-1 protease
Eur. J. Biochem.
270
1231-1239
2003
Human immunodeficiency virus 1
Cai, Y.D.; Yu, H.; Chou, K.C.
Artificial neural network method for predicting HIV protease cleavage sites in protein
J. Protein Chem.
17
607-615
1998
Human immunodeficiency virus 1
Szeltner, Z.; Polgar, L.
Rate-determining steps in HIV-1 protease catalysis. The hydrolysis of the most specific substrate
J. Biol. Chem.
271
32180-32184
1996
Human immunodeficiency virus 1
Prabu-Jeyabalan, M.; Nalivaika, E.; Schiffer, C.A.
Substrate shape determines specificity of recognition for HIV-1 protease: analysis of crystal structures of six substrate complexes
Structure
10
369-381
2002
Human immunodeficiency virus 1
Szeltner, Z.; Polgar, L.
Conformational stability and catalytic activity of HIV-1 protease are both enhanced at high salt concentration
J. Biol. Chem.
271
5458-5463
1996
Human immunodeficiency virus 1
Vance, J.E.; LeBlanc, D.A.; Wingfield, P.; London, R.E.
Conformational selectivity of HIV-1 protease cleavage of X-Pro peptide bonds and its implications
J. Biol. Chem.
272
15603-15606
1997
Human immunodeficiency virus 1
Louis, J.M.; Wondrak, E.M.; Kimmel, A.R.; Wingfield, P.T.; Nashed, N.T.
Proteolytic processing of HIV-1 protease precursor, kinetics and mechanism
J. Biol. Chem.
274
23437-23442
1999
Human immunodeficiency virus 1
Hong, L.; Zhang, X.C.; Hartsuck, J.A.; Tang, J.
Crystal structure of an in vivo HIV-1 protease mutant in complex with saquinavir: insights into the mechanisms of drug resistance
Protein Sci.
9
1898-1904
2000
Human immunodeficiency virus 1
Pillai, B.; Kannan, K.K.; Hosur, M.V.
1.9.ANG. X-ray study shows closed flap conformation in crystals of tethered HIV-1 PR
Proteins Struct. Funct. Genet.
43
57-64
2001
Human immunodeficiency virus 1
Ishima, R.; Ghirlando, R.; Tozser, J.; Gronenborn, A.M.; Torchia, D.A.; Louis, J.M.
Folded monomer of HIV-1 protease
J. Biol. Chem.
276
49110-49116
2001
Human immunodeficiency virus 1 (P03367), Human immunodeficiency virus 1
Louis, J.M.; Ishima, R.; Nesheiwat, I.; Pannell, L.K.; Lynch, S.M.; Torchia, D.A.; Gronenborn, A.M.
Revisiting monomeric HIV-1 protease. Characterization and redesign for improved properties
J. Biol. Chem.
278
6085-6092
2003
Human immunodeficiency virus 1 (P04585), Human immunodeficiency virus 1
Prabu-Jeyabalan, M.; Nalivaika, E.; Schiffer, C.A.
How does a symmetric dimer recognize an asymmetric substrate? A substrate complex of HIV-1 protease
J. Mol. Biol.
301
1207-1220
2000
Human immunodeficiency virus 1 (P03369), Human immunodeficiency virus 1
Mahalingam, B.; Louis, J.M.; Hung, J.; Harrison, R.W.; Weber, I.T.
Structural implications of drug-resistant mutants of HIV-1 protease: high-resolution crystal structures of the mutant protease/substrate analogue complexes
Proteins
43
455-464
2001
Human immunodeficiency virus 1
Pettit, S.C.; Henderson, G.J.; Schiffer, C.A.; Swanstrom, R.
Replacement of the P1 amino acid of human immunodeficiency virus type 1 Gag processing sites can inhibit or enhance the rate of cleavage by the viral protease
J. Virol.
76
10226-10233
2002
Human immunodeficiency virus 1
Louis, J.M.; Clore, G.M.; Gronenborn, A.M.
Autoprocessing of HIV-1 protease is tightly coupled to protein folding
Nat. Struct. Biol.
6
868-875
1999
Human immunodeficiency virus 1
Ventoso, I.; Blanco, R.; Perales, C.; Carrasco, L.
HIV-1 protease cleaves eukaryotic initiation factor 4G and inhibits cap-dependent translation
Proc. Natl. Acad. Sci. USA
98
12966-12971
2001
Human immunodeficiency virus 1
Hong, L.; Hartsuck, J.A.; Foundling, S.; Ermolieff, J.; Tang, J.
Active-site mobility in human immunodeficiency virus, type 1, protease as demonstrated by crystal structure of A28S mutant
Protein Sci.
7
300-305
1998
Human immunodeficiency virus 1
Wallqvist, A.; Smythers, G.W.; Covell, D.G.
A cooperative folding unit in HIV-1 protease. Implications for protein stability and occurrence of drug-induced mutations
Protein Eng.
11
999-1005
1998
Human immunodeficiency virus 1
Xie, D.; Gulnik, S.; Gustchina, E.; Yu, B.; Shao, W.; Qoronfleh, W.; Nathan, A.; Erickson, J.W.
Drug resistance mutations can effect dimer stability of HIV-1 protease at neutral pH
Protein Sci.
8
1702-1707
1999
Human immunodeficiency virus 1
Wlodawer, A.; Miller, M.; Jaskolski, M.; Snthyanarayana, B.K.; Baldwin, E.
Weber, I.T.; Selk, L.M.; Clawson, L.; Schneider, J.; Kent, S.B.H.: Conserved folding in retroviral proteases:crystal structure of a synthetic HIV-1 protease
Science
245
616-621
1989
Human immunodeficiency virus 1 (P03369), Human immunodeficiency virus 1
Abbenante, G.; March, D.R.; Bergman, D.A.; Hunt, P.A.; Garnham, B.; Dancer, R.J.; Martin, J.L.; Fairlie, D.P.
Regioselective structural and functional mimicry of peptides -design of hydrolytically-stable cyclic peptidomimetic inhibitors of HIV-1 protease
J. Am. Chem. Soc.
117
10220-10226
1995
Human immunodeficiency virus 1 (P03369)
-
March, D.R.; Abbenante, G.; Bergman, D.A.; Brinkworth, R.I.; Wickramasinghe, W.; Begun, J.; Martin, J.L.; Fairlie, D.P.
Substrate-based cyclic peptidomimetics of Phe-Ile-Val that inhibit HIV-1 protease using a novel enzyme-binding mode
J. Am. Chem. Soc.
118
3375-3379
1996
Human immunodeficiency virus 1 (P03369)
-
Guo, F.; Gabor, J.; Cen, S.; Hu, K.; Mouland, A.J.; Kleiman, L.
Inhibition of cellular HIV-1 protease activity by lysyl-tRNA synthetase
J. Biol. Chem.
280
26018-26023
2005
Human immunodeficiency virus 1
Clemente, J.C.; Moose, R.E.; Hemrajani, R.; Whitford, L.R.; Govindasamy, L.; Reutzel, R.; McKenna, R.; Agbandje-McKenna, M.; Goodenow, M.M.; Dunn, B.M.
Comparing the accumulation of active- and nonactive-site mutations in the HIV-1 protease
Biochemistry
43
12141-12151
2004
Human immunodeficiency virus 1
Toth, G.; Borics, A.
Closing of the flaps of HIV-1 protease induced by substrate binding: a model of a flap closing mechanism in retroviral aspartic proteases
Biochemistry
45
6606-6614
2006
Human immunodeficiency virus 1
Hamada, Y.; Matsumoto, H.; Yamaguchi, S.; Kimura, T.; Hayashi, Y.; Kiso, Y.
Water-soluble prodrugs of dipeptide HIV protease inhibitors based on O-> N intramolecular acyl migration: Design, synthesis and kinetic study
Bioorg. Med. Chem.
12
159-170
2004
Human immunodeficiency virus 1
Specker, E.; Boettcher, J.; Brass, S.; Heine, A.; Lilie, H.; Schoop, A.; Mueller, G.; Griebenow, N.; Klebe, G.
Unexpected novel binding mode of pyrrolidine-based aspartyl protease inhibitors: design, synthesis and crystal structure in complex with HIV protease
ChemMedChem
1
106-117
2006
Human immunodeficiency virus 1
Tie, Y.; Boross, P.I.; Wang, Y.F.; Gaddis, L.; Liu, F.; Chen, X.; Tozser, J.; Harrison, R.W.; Weber, I.T.
Molecular basis for substrate recognition and drug resistance from 1.1 to 1.6 angstroms resolution crystal structures of HIV-1 protease mutants with substrate analogs
FEBS J.
272
5265-5277
2005
Human immunodeficiency virus 1
Dunn, B.M.
Human immunodeficiency virus 2 retropepsin
Handbook of Proteolytic Enzymes (Barrett, A. J. ; Rowlings, N. D. ; Woessner, J. F. , eds. )
1
154-157
2004
Human immunodeficiency virus 1
-
Surleraux, D.L.; de Kock, H.A.; Verschueren, W.G.; Pille, G.M.; Maes, L.J.; Peeters, A.; Vendeville, S.; De Meyer, S.; Azijn, H.; Pauwels, R.; de Bethune, M.P.; King, N.M.; Prabu-Jeyabalan, M.; Schiffer, C.A.; Wigerinck, P.B.
Design of HIV-1 protease inhibitors active on multidrug-resistant virus
J. Med. Chem.
48
1965-1973
2005
Human immunodeficiency virus 1
Skalova, T.; Dohnalek, J.; Duskova, J.; Petrokova, H.; Hradilek, M.; Soucek, M.; Konvalinka, J.; Hasek, J.
HIV-1 protease mutations and inhibitor modifications monitored on a series of complexes. Structural basis for the effect of the A71V mutation on the active site
J. Med. Chem.
49
5777-5784
2006
Human immunodeficiency virus 1
Tie, Y.; Boross, P.I.; Wang, Y.F.; Gaddis, L.; Hussain, A.K.; Leshchenko, S.; Ghosh, A.K.; Louis, J.M.; Harrison, R.W.; Weber, I.T.
High resolution crystal structures of HIV-1 protease with a potent non-peptide inhibitor (UIC-94017) active against multi-drug-resistant clinical strains
J. Mol. Biol.
338
341-352
2004
Human immunodeficiency virus 1
Liu, F.; Boross, P.I.; Wang, Y.F.; Tozser, J.; Louis, J.M.; Harrison, R.W.; Weber, I.T.
Kinetic, stability, and structural changes in high-resolution crystal structures of HIV-1 protease with drug-resistant mutations L24I, I50V, and G73S
J. Mol. Biol.
354
789-800
2005
Human immunodeficiency virus 1
Liu, F.; Kovalevsky, A.Y.; Louis, J.M.; Boross, P.I.; Wang, Y.F.; Harrison, R.W.; Weber, I.T.
Mechanism of drug resistance revealed by the crystal structure of the unliganded HIV-1 protease with F53L mutation
J. Mol. Biol.
358
1191-1199
2006
Human immunodeficiency virus 1
Shuman, C.F.; Haemaelaeinen, M.D.; Danielson, U.H.
Kinetic and thermodynamic characterization of HIV-1 protease inhibitors
J. Mol. Recognit.
17
106-119
2004
Human immunodeficiency virus 1
Bagossi, P.; Sperka, T.; Feher, A.; Kadas, J.; Zahuczky, G.; Miklossy, G.; Boross, P.; Toezser, J.
Amino acid preferences for a critical substrate binding subsite of retroviral proteases in type 1 cleavage sites
J. Virol.
79
4213-4218
2005
Human immunodeficiency virus 1 (P04587)
Kovalskyy, D.; Dubyna, V.; Mark, A.E.; Kornelyuk, A.
A molecular dynamics study of the structural stability of HIV-1 protease under physiological conditions: the role of Na+ ions in stabilizing the active site
Proteins
58
450-458
2005
Human immunodeficiency virus 1
Ozer, N.; Haliloglu, T.; Schiffer, C.A.
Substrate specificity in HIV-1 protease by a biased sequence search method
Proteins
64
444-456
2006
Human immunodeficiency virus 1
Kovalevsky, A.Y.; Chumanevich, A.A.; Liu, F.; Louis, J.M.; Weber, I.T.
Caught in the act: the 1.5 A resolution crystal structures of the HIV-1 protease and the I54V mutant reveal a tetrahedral reaction intermediate
Biochemistry
46
14854-14864
2007
Human immunodeficiency virus 1
Tyndall, J.D.; Pattenden, L.K.; Reid, R.C.; Hu, S.H.; Alewood, D.; Alewood, P.F.; Walsh, T.; Fairlie, D.P.; Martin, J.L.
Crystal structures of highly constrained substrate and hydrolysis products bound to HIV-1 protease. Implications for the catalytic mechanism
Biochemistry
47
3736-3744
2008
Human immunodeficiency virus 1
Coman, R.M.; Robbins, A.H.; Fernandez, M.A.; Gilliland, C.T.; Sochet, A.A.; Goodenow, M.M.; McKenna, R.; Dunn, B.M.
The contribution of naturally occurring polymorphisms in altering the biochemical and structural characteristics of HIV-1 subtype C protease
Biochemistry
47
731-743
2008
Human immunodeficiency virus 1
Mimoto, T.; Nojima, S.; Terashima, K.; Takaku, H.; Shintani, M.; Hayashi, H.
Structure-activity relationships of novel HIV-1 protease inhibitors containing the 3-amino-2-chlorobenzoyl-allophenylnorstatine structure
Bioorg. Med. Chem.
16
1299-1308
2008
Human immunodeficiency virus 1
Narendra Babu, S.N.; Rangappa, K.S.
Design, synthesis and structure-activity study of shorter hexa peptide analogues as HIV-1 protease inhibitors
Bioorg. Med. Chem.
16
874-880
2008
Human immunodeficiency virus 1
Trylska, J.; Tozzini, V.; Chang, C.E.; McCammon, J.A.
HIV-1 protease substrate binding and product release pathways explored with coarse-grained molecular dynamics
Biophys. J.
92
4179-4187
2007
Human immunodeficiency virus 1
Layten, M.; Hornak, V.; Simmerling, C.
The open structure of a multi-drug-resistant HIV-1 protease is stabilized by crystal packing contacts
J. Am. Chem. Soc.
128
13360-13361
2006
Human immunodeficiency virus 1
Altman, M.D.; Ali, A.; Kumar Reddy, G.S.; Nalam, M.N.; Anjum, S.G.; Cao, H.; Chellappan, S.; Kairys, V.; Fernandes, M.X.; Gilson, M.K.; Schiffer, C.A.; Rana, T.M.; Tidor, B.
HIV-1 protease inhibitors from inverse design in the substrate envelope exhibit subnanomolar binding to drug-resistant variants
J. Am. Chem. Soc.
130
6099-6113
2008
Human immunodeficiency virus 1
Ishima, R.; Torchia, D.A.; Louis, J.M.
Mutational and structural studies aimed at characterizing the monomer of HIV-1 protease and its precursor
J. Biol. Chem.
282
17190-17199
2007
Human immunodeficiency virus 1
Sayer, J.M.; Liu, F.; Ishima, R.; Weber, I.T.; Louis, J.M.
Effect of the active-site D25N mutation on the structure, stability and ligand binding of the mature HIV-1 protease
J. Biol. Chem.
283
13459-13470
2008
Human immunodeficiency virus 1
Gohda, K.
A quantitative structure-activity relationship study for structurally diverse HIV-1 protease inhibitors: Contribution of conformational flexibility to inhibitory activity
J. Enzyme Inhib. Med. Chem.
21
609-615
2006
Human immunodeficiency virus 1
Clemente, J.C.; Robbins, A.; Grana, P.; Paleo, M.R.; Correa, J.F.; Villaverde, M.C.; Sardina, F.J.; Govindasamy, L.; Agbandje-McKenna, M.; McKenna, R.; Dunn, B.M.; Sussman, F.
Design, synthesis, evaluation, and crystallographic-based structural studies of HIV-1 protease inhibitors with reduced response to the V82A mutation
J. Med. Chem.
51
852-860
2008
Human immunodeficiency virus 1
Kozisek, M.; Bray, J.; Rezacova, P.; Saskova, K.; Brynda, J.; Pokorna, J.; Mammano, F.; Rulisek, L.; Konvalinka, J.
Molecular analysis of the HIV-1 resistance development: enzymatic activities, crystal structures, and thermodynamics of nelfinavir-resistant HIV protease mutants
J. Mol. Biol.
374
1005-1016
2007
Human immunodeficiency virus 1
Kozisek, M.; Saskova, K.G.; Rezacova, P.; Brynda, J.; van Maarseveen, N.M.; De Jong, D.; Boucher, C.A.; Kagan, R.M.; Nijhuis, M.; Konvalinka, J.
Ninety-nine is not enough: molecular characterization of inhibitor resistant HIV-1 protease mutants with insertions in the flap region
J. Virol.
82
5869-5878
2008
Human immunodeficiency virus 1 (P03367), Human immunodeficiency virus 1
Kona, J.
Theoretical study on the mechanism of a ring-opening reaction of oxirane by the active-site aspartic dyad of HIV-1 protease
Org. Biomol. Chem.
6
359-365
2008
Human immunodeficiency virus 1
Das, A.; Prashar, V.; Mahale, S.; Serre, L.; Ferrer, J.L.; Hosur, M.V.
Crystal structure of HIV-1 protease in situ product complex and observation of a low-barrier hydrogen bond between catalytic aspartates
Proc. Natl. Acad. Sci. USA
103
18464-18469
2006
Human immunodeficiency virus 1
Chellappan, S.; Kairys, V.; Fernandes, M.X.; Schiffer, C.; Gilson, M.K.
Evaluation of the substrate envelope hypothesis for inhibitors of HIV-1 protease
Proteins
68
561-567
2007
Human immunodeficiency virus 1
Altman, M.D.; Nalivaika, E.A.; Prabu-Jeyabalan, M.; Schiffer, C.A.; Tidor, B.
Computational design and experimental study of tighter binding peptides to an inactivated mutant of HIV-1 protease
Proteins
70
678-694
2008
Human immunodeficiency virus 1
Thomas, J.A.; Shulenin, S.; Coren, L.V.; Bosche, W.J.; Gagliardi, T.D.; Gorelick, R.J.; Oroszlan, S.
Characterization of human immunodeficiency virus type 1 (HIV-1) containing mutations in the nucleocapsid protein at a putative HIV-1 protease cleavage site
Virology
354
261-270
2006
Human immunodeficiency virus 1
Eizert, H.; Bander, P.; Bagossi, P.; Sperka, T.; Miklossy, G.; Boross, P.; Weber, I.T.; Toezser, J.
Amino acid preferences of retroviral proteases for amino-terminal positions in a type 1 cleavage site
J. Virol.
82
10111-10117
2008
Human immunodeficiency virus 1
Lee, J.S.; Hattori, M.; Kim, J.
Inhibition of HIV-1 protease and RNase H of HIV-1 reverse transcriptase activities by long chain phenols from the sarcotestas of Ginkgo biloba
Planta Med.
74
532-534
2008
Human immunodeficiency virus 1
Mahmoud, K.A.; Hrapovic, S.; Luong, J.H.
Picomolar detection of protease using peptide/single walled carbon nanotube/gold nanoparticle-modified electrode
ACS Nano
2
1051-1057
2008
Human immunodeficiency virus 1
Dekhtyar, T.; Ng, T.I.; Lu, L.; Masse, S.; DeGoey, D.A.; Flosi, W.J.; Grampovnik, D.J.; Klein, L.L.; Kempf, D.J.; Molla, A.
Characterization of a novel human immunodeficiency virus type 1 protease inhibitor, A-790742
Antimicrob. Agents Chemother.
52
1337-1344
2008
Human immunodeficiency virus 1
Davis, D.A.; Tebbs, I.R.; Daniels, S.I.; Stahl, S.J.; Kaufman, J.D.; Wingfield, P.; Bowman, M.J.; Chmielewski, J.; Yarchoan, R.
Analysis and characterization of dimerization inhibition of a multi-drug-resistant human immunodeficiency virus type 1 protease using a novel size-exclusion chromatographic approach
Biochem. J.
419
497-506
2009
Human immunodeficiency virus 1
Zhou, L.; Yang, Q.; Wang, Y.; Hu, Y.; Luo, X.; Bai, D.; Li, S.
Synthesis and biological evaluation of novel isopropanolamine derivatives as non-peptide human immunodeficiency virus protease inhibitors
Chem. Pharm. Bull.
56
1147-1152
2008
Human immunodeficiency virus 1
Lee, J.S.; Miyashiro, H.; Nakamura, N.; Hattori, M.
Two new triterpenes from the rhizome of Dryopteris crassirhizoma, and inhibitory activities of its constituents on human immunodeficiency virus-1 protease
Chem. Pharm. Bull.
56
711-714
2008
Human immunodeficiency virus 1
Dumans, A.T.; Barreto, C.C.; Santos, A.F.; Arruda, M.; Sousa, T.M.; Machado, E.S.; Sabino, E.C.; Brindeiro, R.M.; Tanuri, A.; Duarte, A.J.; Soares, M.A.
Distinct resistance mutation and polymorphism acquisition in HIV-1 protease of subtypes B and F1 from children and adult patients under virological failure
Infect. Genet. Evol.
9
62-70
2009
Human immunodeficiency virus 1
Gonzalez, L.M.; Santos, A.F.; Abecasis, A.B.; Van Laethem, K.; Soares, E.A.; Deforche, K.; Tanuri, A.; Camacho, R.; Vandamme, A.M.; Soares, M.A.
Impact of HIV-1 protease mutations A71V/T and T74S on M89I/V-mediated protease inhibitor resistance in subtype G isolates
J. Antimicrob. Chemother.
61
1201-1204
2008
Human immunodeficiency virus 1
Lambert-Niclot, S.; Flandre, P.; Malet, I.; Canestri, A.; Soulie, C.; Tubiana, R.; Brunet, C.; Wirden, M.; Katlama, C.; Calvez, V.; Marcelin, A.G.
Impact of gag mutations on selection of darunavir resistance mutations in HIV-1 protease
J. Antimicrob. Chemother.
62
905-908
2008
Human immunodeficiency virus 1
Fong, P.; McNamara, J.P.; Hillier, I.H.; Bryce, R.A.
Assessment of QM/MM scoring functions for molecular docking to HIV-1 protease
J. Chem. Inf. Model.
49
913-924
2009
Human immunodeficiency virus 1
Liu, X.; Xiu, Z.; Hao, C.
Drug-resistant molecular mechanism of CRF01_AE HIV-1 protease due to V82F mutation
J. Comput. Aided Mol. Des.
23
261-272
2009
Human immunodeficiency virus 1
Liu, F.; Kovalevsky, A.Y.; Tie, Y.; Ghosh, A.K.; Harrison, R.W.; Weber, I.T.
Effect of flap mutations on structure of HIV-1 protease and inhibition by saquinavir and darunavir
J. Mol. Biol.
381
102-115
2008
Human immunodeficiency virus 1
Boettcher, J.; Blum, A.; Heine, A.; Diederich, W.E.; Klebe, G.
Structural and kinetic analysis of pyrrolidine-based inhibitors of the drug-resistant Ile84Val mutant of HIV-1 protease
J. Mol. Biol.
383
347-357
2008
Human immunodeficiency virus 1
Noel, A.F.; Bilsel, O.; Kundu, A.; Wu, Y.; Zitzewitz, J.A.; Matthews, C.R.
The folding free-energy surface of HIV-1 protease: insights into the thermodynamic basis for resistance to inhibitors
J. Mol. Biol.
387
1002-1016
2009
Human immunodeficiency virus 1
Chen, J.; Yang, M.; Hu, G.; Shi, S.; Yi, C.; Zhang, Q.
Insights into the functional role of protonation states in the HIV-1 protease-BEA369 complex: molecular dynamics simulations and free energy calculations
J. Mol. Model.
15
1245-1252
2009
Human immunodeficiency virus 1
Mosebi, S.; Morris, L.; Dirr, H.W.; Sayed, Y.
Active-site mutations in the South african human immunodeficiency virus type 1 subtype C protease have a significant impact on clinical inhibitor binding: kinetic and thermodynamic study
J. Virol.
82
11476-11479
2008
Human immunodeficiency virus 1
Bandaranayake, R.M.; Prabu-Jeyabalan, M.; Kakizawa, J.; Sugiura, W.; Schiffer, C.A.
Structural analysis of human immunodeficiency virus type 1 CRF01_AE protease in complex with the substrate p1-p6
J. Virol.
82
6762-6766
2008
Human immunodeficiency virus 1 (Q90VT5), Human immunodeficiency virus 1
Miura, T.; Brockman, M.A.; Brumme, Z.L.; Brumme, C.J.; Pereyra, F.; Trocha, A.; Block, B.L.; Schneidewind, A.; Allen, T.M.; Heckerman, D.; Walker, B.D.
HLA-associated alterations in replication capacity of chimeric NL4-3 viruses carrying gag-protease from elite controllers of human immunodeficiency virus type 1
J. Virol.
83
140-149
2009
Human immunodeficiency virus 1
Emmons, T.L.; Shuck, M.E.; Babcock, M.S.; Holloway, J.S.; Leone, J.W.; Durbin, J.D.; Paddock, D.J.; Prince, D.B.; Heinrikson, R.L.; Fischer, H.D.; Bienkowski, M.J.; Benson, T.E.; Tomasselli, A.G.
Large-scale purification of human BACE expressed in mammalian cells and removal of the prosegment with HIV-1 protease to improve crystal diffraction
Protein Pept. Lett.
15
119-130
2008
Human immunodeficiency virus 1
Sayer, J.M.; Louis, J.M.
Interactions of different inhibitors with active-site aspartyl residues of HIV-1 protease and possible relevance to pepsin
Proteins
75
556-568
2008
Human immunodeficiency virus 1
Moore, M.D.; Fu, W.; Soheilian, F.; Nagashima, K.; Ptak, R.G.; Pathak, V.K.; Hu, W.S.
Suboptimal inhibition of protease activity in human immunodeficiency virus type 1: effects on virion morphogenesis and RNA maturation
Virology
379
152-160
2008
Human immunodeficiency virus 1
Tojo, Y.; Koh, Y.; Amano, M.; Aoki, M.; Das, D.; Ghosh, A.K.; Mitsuya, H.
Novel Protease Inhibitors (PIs) Containing Macrocyclic Components and 3(R),3a(S),6a(R)-bis-Tetrahydrofuranylurethane (bis-THF) That Are Potent Against Multi-PI-Resistant HIV-1 Variants In Vitro
Antimicrob. Agents Chemother.
54
3460-3470
2010
Human immunodeficiency virus 1
Clayton, R.; Ohagen, A.; Nicol, F.; Del Vecchio, A.M.; Jonckers, T.H.; Goethals, O.; Van Loock, M.; Michiels, L.; Grigsby, J.; Xu, Z.; Zhang, Y.P.; Gutshall, L.L.; Cunningham, M.; Jiang, H.; Bola, S.; Sarisky, R.T.; Hertogs, K.
Sustained and specific in vitro inhibition of HIV-1 replication by a protease inhibitor encapsulated in gp120-targeted liposomes
Antiviral Res.
84
142-149
2009
Human immunodeficiency virus 1
Lee, J.; Huh, M.S.; Kim, Y.C.; Hattori, M.; Otake, T.
Lignan, sesquilignans and dilignans, novel HIV-1 protease and cytopathic effect inhibitors purified from the rhizomes of Saururus chinensis
Antiviral Res.
85
425-428
2010
Human immunodeficiency virus 1
Bihani, S.C.; Das, A.; Prashar, V.; Ferrer, J.L.; Hosur, M.V.
Resistance mechanism revealed by crystal structures of unliganded nelfinavir-resistant HIV-1 protease non-active site mutants N88D and N88S
Biochem. Biophys. Res. Commun.
389
295-300
2009
Human immunodeficiency virus 1
Chang, M.W.; Giffin, M.J.; Muller, R.; Savage, J.; Lin, Y.C.; Hong, S.; Jin, W.; Whitby, L.R.; Elder, J.H.; Boger, D.L.; Torbett, B.E.
Identification of broad-based HIV-1 protease inhibitors from combinatorial libraries
Biochem. J.
429
527-532
2010
Human immunodeficiency virus 1
Blackburn, M.E.; Veloro, A.M.; Fanucci, G.E.
Monitoring inhibitor-induced conformational population shifts in HIV-1 protease by pulsed EPR spectroscopy
Biochemistry
48
8765-8767
2009
Human immunodeficiency virus 1
Genoni, A.; Morra, G.; Merz, K.M.; Colombo, G.
Computational study of the resistance shown by the subtype B/HIV-1 protease to currently known inhibitors
Biochemistry
49
4283-4295
2010
Human immunodeficiency virus 1
Jochim, A.L.; Miller, S.E.; Angelo, N.G.; Arora, P.S.
Evaluation of triazolamers as active site inhibitors of HIV-1 protease
Bioorg. Med. Chem. Lett.
19
6023-6026
2009
Human immunodeficiency virus 1
Ghosh, A.K.; Gemma, S.; Simoni, E.; Baldridge, A.; Walters, D.E.; Ide, K.; Tojo, Y.; Koh, Y.; Amano, M.; Mitsuya, H.
Synthesis and biological evaluation of novel allophenylnorstatine-based HIV-1 protease inhibitors incorporating high affinity P2-ligands
Bioorg. Med. Chem. Lett.
20
1241-1246
2010
Human immunodeficiency virus 1
Waibel, M.; Pitrat, D.; Hasserodt, J.
On the inhibition of HIV-1 protease by hydrazino-ureas displaying the N-->C=O interaction
Bioorg. Med. Chem.
17
3671-3679
2009
Human immunodeficiency virus 1
Lu, D.; Sham, Y.Y.; Vince, R.
Design, asymmetric synthesis, and evaluation of pseudosymmetric sulfoximine inhibitors against HIV-1 protease
Bioorg. Med. Chem.
18
2037-2048
2010
Human immunodeficiency virus 1
Deeb, O.; Goodarzi, M.
Exploring QSARs for inhibitory activity of non-peptide HIV-1 protease inhibitors by GA-PLS and GA-SVM
Chem. Biol. Drug Des.
75
506-514
2010
Human immunodeficiency virus 1
da Cunha, E.F.; Sippl, W.; de Castro Ramalho, T.; Ceva Antunes, O.A.; de Alencastro, R.B.; Albuquerque, M.G.
3D-QSAR CoMFA/CoMSIA models based on theoretical active conformers of HOE/BAY-793 analogs derived from HIV-1 protease inhibitor complexes
Eur. J. Med. Chem.
44
4344-4352
2009
Human immunodeficiency virus 1
Hu, G.D.; Zhu, T.; Zhang, S.L.; Wang, D.; Zhang, Q.G.
Some insights into mechanism for binding and drug resistance of wild type and I50V V82A and I84V mutations in HIV-1 protease with GRL-98065 inhibitor from molecular dynamic simulations
Eur. J. Med. Chem.
45
227-235
2010
Human immunodeficiency virus 1
Chandra, S.; Mondal, D.; Agrawal, K.C.
HIV-1 protease inhibitor induced oxidative stress suppresses glucose stimulated insulin release: protection with thymoquinone
Exp. Biol. Med. (Maywood)
234
442-453
2009
Human immunodeficiency virus 1
Torbeev, V.Y.; Raghuraman, H.; Mandal, K.; Senapati, S.; Perozo, E.; Kent, S.B.
Dynamics of "flap" structures in three HIV-1 protease/inhibitor complexes probed by total chemical synthesis and pulse-EPR spectroscopy
J. Am. Chem. Soc.
131
884-885
2009
Human immunodeficiency virus 1
Li, D.; Liu, M.S.; Ji, B.; Hwang, K.; Huang, Y.
Coarse-grained molecular dynamics of ligands binding into protein: The case of HIV-1 protease inhibitors
J. Chem. Phys.
130
215102
2009
Human immunodeficiency virus 1
Muratori, C.; Ruggiero, E.; Sistigu, A.; Bona, R.; Federico, M.
Human immunodeficiency virus type 1 (HIV-1) protease inhibitors block cell-to-cell HIV-1 endocytosis in dendritic cells
J. Gen. Virol.
90
2777-2787
2009
Human immunodeficiency virus 1
Ghosh, A.K.; Leshchenko-Yashchuk, S.; Anderson, D.D.; Baldridge, A.; Noetzel, M.; Miller, H.B.; Tie, Y.; Wang, Y.F.; Koh, Y.; Weber, I.T.; Mitsuya, H.
Design of HIV-1 protease inhibitors with pyrrolidinones and oxazolidinones as novel P1-ligands to enhance backbone-binding interactions with protease: synthesis, biological evaluation, and protein-ligand X-ray studies
J. Med. Chem.
52
3902-3914
2009
Human immunodeficiency virus 1
Bonini, C.; Chiummiento, L.; De Bonis, M.; Di Blasio, N.; Funicello, M.; Lupattelli, P.; Pandolfo, R.; Tramutola, F.; Berti, F.
Synthesis of new thienyl ring containing HIV-1 protease inhibitors: promising preliminary pharmacological evaluation against recombinant HIV-1 proteases
J. Med. Chem.
53
1451-1457
2010
Human immunodeficiency virus 1
Mahalingam, A.K.; Axelsson, L.; Ekegren, J.K.; Wannberg, J.; Kihlstroem, J.; Unge, T.; Wallberg, H.; Samuelsson, B.; Larhed, M.; Hallberg, A.
HIV-1 protease inhibitors with a transition-state mimic comprising a tertiary alcohol: improved antiviral activity in cells
J. Med. Chem.
53
607-615
2010
Human immunodeficiency virus 1
Khedkar, V.M.; Ambre, P.K.; Verma, J.; Shaikh, M.S.; Pissurlenkar, R.R.; Coutinho, E.C.
Molecular docking and 3D-QSAR studies of HIV-1 protease inhibitors
J. Mol. Model.
16
1251-1268
2010
Human immunodeficiency virus 1
Dirauf, P.; Meiselbach, H.; Sticht, H.
Effects of the V82A and I54V mutations on the dynamics and ligand binding properties of HIV-1 protease
J. Mol. Model.
16
1577-1583
2010
Human immunodeficiency virus 1
Chen, J.; Zhang, S.; Liu, X.; Zhang, Q.
Insights into drug resistance of mutations D30N and I50V to HIV-1 protease inhibitor TMC-114: free energy calculation and molecular dynamic simulation
J. Mol. Model.
16
459-468
2010
Human immunodeficiency virus 1
El Dine, R.S.; El Halawany, A.M.; Ma, C.M.; Hattori, M.
Inhibition of the dimerization and active site of HIV-1 protease by secondary metabolites from the Vietnamese mushroom Ganoderma colossum
J. Nat. Prod.
72
2019-2023
2009
Human immunodeficiency virus 1
Ramachary, D.B.; Vijayendar Reddy, Y.
A general approach to chiral building blocks via direct amino acid-catalyzed cascade three-component reductive alkylations: formal total synthesis of HIV-1 protease inhibitors, antibiotic agglomerins, brefeldin A, and (R)-gamma-hexanolide
J. Org. Chem.
75
74-85
2010
Human immunodeficiency virus 1
Nalam, M.N.; Ali, A.; Altman, M.D.; Reddy, G.S.; Chellappan, S.; Kairys, V.; Ozen, A.; Cao, H.; Gilson, M.K.; Tidor, B.; Rana, T.M.; Schiffer, C.A.
Evaluating the substrate-envelope hypothesis: structural analysis of novel HIV-1 protease inhibitors designed to be robust against drug resistance
J. Virol.
84
5368-5378
2010
Human immunodeficiency virus 1
Vathipadiekal, V.; Umasankar, P.K.; Patole, M.S.; Rao, M.
Molecular cloning, over expression, and activity studies of a peptidic HIV-1 protease inhibitor: designed synthetic gene to functional recombinant peptide
Peptides
31
16-21
2010
Human immunodeficiency virus 1
Kumar, P.; Lodge, R.; Trudel, N.; Ouellet, M.; Ouellette, M.; Tremblay, M.J.
Nelfinavir, an HIV-1 protease inhibitor, induces oxidative stress-mediated, caspase-independent apoptosis in Leishmania amastigotes
PLoS Negl. Trop. Dis.
4
e642
2010
Human immunodeficiency virus 1
Castello, A.; Franco, D.; Moral-Lopez, P.; Berlanga, J.J.; Alvarez, E.; Wimmer, E.; Carrasco, L.
HIV- 1 protease inhibits Cap- and poly(A)-dependent translation upon eIF4GI and PABP cleavage
PLoS ONE
4
e7997
2009
Human immunodeficiency virus 1
Hilton, B.J.; Wolkowicz, R.
An Assay to Monitor HIV-1 Protease Activity for the Identification of Novel Inhibitors in T-Cells
PLoS ONE
5
e10940
2010
Human immunodeficiency virus 1
Adachi, M.; Ohhara, T.; Kurihara, K.; Tamada, T.; Honjo, E.; Okazaki, N.; Arai, S.; Shoyama, Y.; Kimura, K.; Matsumura, H.; Sugiyama, S.; Adachi, H.; Takano, K.; Mori, Y.; Hidaka, K.; Kimura, T.; Hayashi, Y.; Kiso, Y.; Kuroki, R.
Structure of HIV-1 protease in complex with potent inhibitor KNI-272 determined by high-resolution X-ray and neutron crystallography
Proc. Natl. Acad. Sci. USA
106
4641-4646
2009
Human immunodeficiency virus 1
Rhee, S.Y.; Taylor, J.; Fessel, W.J.; Kaufman, D.; Towner, W.; Troia, P.; Ruane, P.; Hellinger, J.; Shirvani, V.; Zolopa, A.; Shafer, R.W.
HIV-1 protease mutations and protease inhibitor cross-resistance
Antimicrob. Agents Chemother.
54
4253-4261
2010
Human immunodeficiency virus 1
Lentini, A.; Tabolacci, C.; Melino, S.; Provenzano, B.; Beninati, S.
Post-translational modification of glutamine and lysine residues of HIV-1 aspartyl protease by transglutaminase increases its catalytic activity
Biochem. Biophys. Res. Commun.
393
546-550
2010
Human immunodeficiency virus 1
Newell, N.E.
Cascade detection for the extraction of localized sequence features; specificity results for HIV-1 protease and structure-function results for the Schellman loop
Bioinformatics
27
3415-3422
2011
Human immunodeficiency virus 1
Jones, K.L.; Holloway, M.K.; Su, H.P.; Carroll, S.S.; Burlein, C.; Touch, S.; DiStefano, D.J.; Sanchez, R.I.; Williams, T.M.; Vacca, J.P.; Coburn, C.A.
Epsilon substituted lysinol derivatives as HIV-1 protease inhibitors
Bioorg. Med. Chem. Lett.
20
4065-4068
2010
Human immunodeficiency virus 1, Human immunodeficiency virus 1 IIIb
Gao, B.L.; Zhang, C.M.; Yin, Y.Z.; Tang, L.Q.; Liu, Z.P.
Design and synthesis of potent HIV-1 protease inhibitors incorporating hydroxyprolinamides as novel P2 ligands
Bioorg. Med. Chem. Lett.
21
3730-3733
2011
Human immunodeficiency virus 1
Deng, N.J.; Zheng, W.; Gallicchio, E.; Levy, R.M.
Insights into the dynamics of HIV-1 protease: a kinetic network model constructed from atomistic simulations
J. Am. Chem. Soc.
133
9387-9394
2011
Human immunodeficiency virus 1
Ali, A.; Reddy, G.S.; Nalam, M.N.; Anjum, S.G.; Cao, H.; Schiffer, C.A.; Rana, T.M.
Structure-based design, synthesis, and structure-activity relationship studies of HIV-1 protease inhibitors incorporating phenyloxazolidinones
J. Med. Chem.
53
7699-7708
2010
Human immunodeficiency virus 1 (P03369), Human immunodeficiency virus 1
Ghosh, A.K.; Chapsal, B.D.; Baldridge, A.; Steffey, M.P.; Walters, D.E.; Koh, Y.; Amano, M.; Mitsuya, H.
Design and synthesis of potent HIV-1 protease inhibitors incorporating hexahydrofuropyranol-derived high affinity P2 ligands: structure-activity studies and biological evaluation
J. Med. Chem.
54
622-634
2011
Human immunodeficiency virus 1
Ganguly, A.K.; Alluri, S.S.; Caroccia, D.; Biswas, D.; Wang, C.H.; Kang, E.; Zhang, Y.; McPhail, A.T.; Carroll, S.S.; Burlein, C.; Munshi, V.; Orth, P.; Strickland, C.
Design, synthesis, and X-ray crystallographic analysis of a novel class of HIV-1 protease inhibitors
J. Med. Chem.
54
7176-7183
2011
Human immunodeficiency virus 1
Ozen, A.; Haliloglu, T.; Schiffer, C.A.
Dynamics of preferential substrate recognition in HIV-1 protease: redefining the substrate envelope
J. Mol. Biol.
410
726-744
2011
Human immunodeficiency virus 1
He, M.; Yang, N.; Sun, C.; Yao, X.; Yang, M.
Modification and biological evaluation of novel 4-hydroxy-pyrone derivatives as non-peptidic HIV-1 protease inhibitors
Med. Chem. Res.
20
200-209
2011
Human immunodeficiency virus 1
-
Tie, Y.; Wang, Y.F.; Boross, P.I.; Chiu, T.Y.; Ghosh, A.K.; Tozser, J.; Louis, J.M.; Harrison, R.W.; Weber, I.T.
Critical differences in HIV-1 and HIV-2 protease specificity for clinical inhibitors
Protein Sci.
21
339-350
2012
Human immunodeficiency virus 1 (Q7SSE3), Human immunodeficiency virus 1
Ishima, R.; Gong, Q.; Tie, Y.; Weber, I.; Louis, J.
Highly conserved glycine 86 and arginine 87 residues contribute differently to the structure and activity of the mature HIV-1 protease
Proteins
78
1015-1025
2010
Human immunodeficiency virus 1 (P03367), Human immunodeficiency virus 1
Hallengaerd, D.; Haller, B.K.; Petersson, S.; Boberg, A.; Maltais, A.K.; Isaguliants, M.; Wahren, B.; Brave, A.
Increased expression and immunogenicity of HIV-1 protease following inactivation of the enzymatic activity
Vaccine
29
839-848
2011
Human immunodeficiency virus 1
Agniswamy, J.; Kneller, D.W.; Brothers, R.; Wang, Y.F.; Harrison, R.W.; Weber, I.T.
Highly drug-resistant HIV-1 protease mutant PRS17 shows enhanced binding to substrate analogues
ACS Omega
4
8707-8719
2019
Human immunodeficiency virus 1 (Q5RZ08), Human immunodeficiency virus 1
Windsor, I.W.; Raines, R.T.
A substrate selected by phage display exhibits enhanced side-chain hydrogen bonding to HIV-1 protease
Acta Crystallogr. Sect. D
74
690-694
2018
Human immunodeficiency virus 1 (Q5RZ08), Human immunodeficiency virus 1
Palese, L.L.
Conformations of the HIV-1 protease A crystal structure data set analysis
Biochim. Biophys. Acta
1865
1416-1422
2017
Human immunodeficiency virus 1
Laco, G.S.
HIV-1 protease substrate-groove Role in substrate recognition and inhibitor resistance
Biochimie
118
90-103
2015
Human immunodeficiency virus 1 (Q5RZ08), Human immunodeficiency virus 1
Manning, T.; Walsh, P.
The importance of physicochemical characteristics and nonlinear classifiers in determining HIV-1 protease specificity
Bioengineered
7
65-78
2016
Human immunodeficiency virus 1
Cong, Y.; Li, Y.; Jin, K.; Zhong, S.; Zhang, J.Z.H.; Li, H.; Duan, L.
Exploring the reasons for decrease in binding affinity of HIV-2 against HIV-1 protease complex using interaction entropy under polarized force field
Front. Chem.
6
380
2018
Human immunodeficiency virus 1 (P04587), Human immunodeficiency virus 1
Hu, L.; Hu, P.; Yuan, X.; Luo, X.; You, Z.H.
Incorporating the coevolving information of substrates in predicting HIV-1 protease cleavage sites
IEEE/ACM Trans. Comput. Biol. Bioinform.
17
2017-2028
2020
Human immunodeficiency virus 1
Gerlits, O.; Keen, D.A.; Blakeley, M.P.; Louis, J.M.; Weber, I.T.; Kovalevsky, A.
Room temperature neutron crystallography of drug resistant HIV-1 protease uncovers limitations of X-ray structural analysis at 100 K
J. Med. Chem.
60
2018-2025
2017
Human immunodeficiency virus 1 (Q7SSI0), Human immunodeficiency virus 1
Potempa, M.; Lee, S.K.; Kurt Yilmaz, N.; Nalivaika, E.A.; Rogers, A.; Spielvogel, E.; Carter, C.W.; Schiffer, C.A.; Swanstrom, R.
HIV-1 protease uses bi-specific S2/S2 subsites to optimize cleavage of two classes of target sites
J. Mol. Biol.
430
5182-5195
2018
Human immunodeficiency virus 1
Lv, Y.; Li, J.; Fang, J.; Jiao, X.; Yan, L.; Shan, B.
Systematic profiling of substrate binding response to multidrug-resistant mutations in HIV-1 protease Implication for combating drug resistance
J. Mol. Graph. Model.
74
83-88
2017
Human immunodeficiency virus 1 (Q7SSI0), Human immunodeficiency virus 1
Olajuyigbe, F.M.; Demitri, N.; De Zorzi, R.; Geremia, S.
Developing HIV-1 protease inhibitors through stereospecific reactions in protein crystals
Molecules
21
1458
2016
Human immunodeficiency virus 1 (Q7SSI0), Human immunodeficiency virus 1
De Gassart, A.; Bujisic, B.; Zaffalon, L.; Decosterd, L.A.; Di Micco, A.; Frera, G.; Tallant, R.; Martinon, F.
An inhibitor of HIV-1 protease modulates constitutive eIF2alpha dephosphorylation to trigger a specific integrated stress response
Proc. Natl. Acad. Sci. USA
113
E117-E126
2016
Human immunodeficiency virus 1
Deshmukh, L.; Tugarinov, V.; Louis, J.M.; Clore, G.M.
Binding kinetics and substrate selectivity in HIV-1 protease-Gag interactions probed at atomic resolution by chemical exchange NMR
Proc. Natl. Acad. Sci. USA
114
E9855-E9862
2017
Human immunodeficiency virus 1
Yu, Y.; Wang, J.; Shao, Q.; Shi, J.; Zhu, W.
Effects of drug-resistant mutations on the dynamic properties of HIV-1 protease and inhibition by amprenavir and darunavir
Sci. Rep.
5
10517
2015
Human immunodeficiency virus 1 (Q7SSI0), Human immunodeficiency virus 1
Triki, D.; Billot, T.; Visseaux, B.; Descamps, D.; Flatters, D.; Camproux, A.C.; Regad, L.
Exploration of the effect of sequence variations located inside the binding pocket of HIV-1 and HIV-2 proteases
Sci. Rep.
8
5789
2018
Human immunodeficiency virus 1 (P04587), Human immunodeficiency virus 1
html completed
