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3.4.23.16: HIV-1 retropepsin

This is an abbreviated version!
For detailed information about HIV-1 retropepsin, go to the full flat file.

Word Map on EC 3.4.23.16

Reaction

specific for a P1 residue that is hydrophobic, and P1' variable, but often Pro =

Synonyms

CRF01_AE protease, Gag protease, HIV aspartyl protease, HIV PR, HIV protease, HIV-1 aspartyl protease, HIV-1 PR, HIV-1 protease, HIV-1 proteinase, HIV-1PR, HIV-2 protease, HIVPR, human immunodeficiency virus 1 protease, human immunodeficiency virus 1 retropepsin, human immunodeficiency virus protease, human immunodeficiency virus type 1 protease, human immunodeficiency virus type I protease, More, PR, PR1, PR2, retropepsin, retroproteinase

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.23 Aspartic endopeptidases
                3.4.23.16 HIV-1 retropepsin

IC50 Value

IC50 Value on EC 3.4.23.16 - HIV-1 retropepsin

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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.025
(1S)-1-[1-[(1S)-1-[1-[(1S)-1-[1-[(1S)-1-(1-[(2S)-1-[(2-ammonioethyl)amino]-1-oxo-3-phenylpropan-2-yl]-1H-1,2,3-triazol-4-yl)-2-phenylethyl]-1H-1,2,3-triazol-4-yl]-2-phenylethyl]-1H-1,2,3-triazol-4-yl]-2-phenylethyl]-1H-1,2,3-triazol-4-yl]-2-phenylethanamine
Human immunodeficiency virus 1
-
-
0.072
(1S)-1-[1-[(1S)-1-[1-[(1S)-1-[1-[(1S)-1-[1-[(2S)-1-(methylamino)-1-oxo-3-phenylpropan-2-yl]-1H-1,2,3-triazol-4-yl]-2-phenylethyl]-1H-1,2,3-triazol-4-yl]-2-phenylethyl]-1H-1,2,3-triazol-4-yl]-2-phenylethyl]-1H-1,2,3-triazol-4-yl]-2-phenylethanaminium
Human immunodeficiency virus 1
-
-
0.06
(1S)-2-methyl-1-[1-[(1S)-1-[1-[(1S)-1-[1-[(1S)-2-methyl-1-[1-[(1R)-1-phenylethyl]-1H-1,2,3-triazol-4-yl]propyl]-1H-1,2,3-triazol-4-yl]-2-phenylethyl]-1H-1,2,3-triazol-4-yl]-2-phenylethyl]-1H-1,2,3-triazol-4-yl]propan-1-amine
Human immunodeficiency virus 1
-
-
0.131
(1S)-2-methyl-1-[1-[(1S)-2-methyl-1-[1-[(1S)-1-[1-[(1S)-2-methyl-1-[1-[(1R)-1-phenylethyl]-1H-1,2,3-triazol-4-yl]propyl]-1H-1,2,3-triazol-4-yl]-2-phenylethyl]-1H-1,2,3-triazol-4-yl]propyl]-1H-1,2,3-triazol-4-yl]propan-1-amine
Human immunodeficiency virus 1
-
-
0.129
(1S)-2-methyl-1-[1-[(1S)-2-phenyl-1-[1-[(1S)-2-phenyl-1-[1-[(1R)-1-phenylethyl]-1H-1,2,3-triazol-4-yl]ethyl]-1H-1,2,3-triazol-4-yl]ethyl]-1H-1,2,3-triazol-4-yl]propan-1-aminium
Human immunodeficiency virus 1
-
-
0.078
(1S)-2-phenyl-1-[1-[(1S)-2-phenyl-1-[1-[(1S)-2-phenyl-1-[1-[(1R)-1-phenylethyl]-1H-1,2,3-triazol-4-yl]ethyl]-1H-1,2,3-triazol-4-yl]ethyl]-1H-1,2,3-triazol-4-yl]ethanaminium
Human immunodeficiency virus 1
-
-
0.029
(1S)-2-phenyl-1-[1-[(1S)-2-phenyl-1-[1-[(1S)-2-phenyl-1-[1-[(1S)-2-phenyl-1-[1-[(1R)-1-phenylethyl]-1H-1,2,3-triazol-4-yl]ethyl]-1H-1,2,3-triazol-4-yl]ethyl]-1H-1,2,3-triazol-4-yl]ethyl]-1H-1,2,3-triazol-4-yl]ethanamine
Human immunodeficiency virus 1
-
-
0.00000079
(2S)-N-[(4S,7S,10S,11R,12R,13S)-10-benzyl-11,12-dihydroxy-4-(naphthalen-1-ylmethyl)-2,2-dioxido-5,8-dioxo-14-phenyl-7-(propan-2-yl)-2l6-thia-3,6,9-triazatetradecan-13-yl]-3-methyl-2-[[(2S)-2-[(methylsulfonyl)amino]-3-(naphthalen-1-yl)propanoyl]amino]butanamide)
Human immunodeficiency virus 1
-
-
0.0000022
(2S,2'S)-N,N'-[(2R,3R)-2,3-dihydroxybutane-1,4-diyl]bis(2-[[(2S)-3-(tert-butylsulfonyl)-2-(naphthalen-1-ylmethyl)propanoyl]amino]-3-methylbutanamide)
Human immunodeficiency virus 1
-
-
0.0000004
(2S,2'S)-N,N'-[(2S,3R,4R,5S)-1,6-bis(1,3-benzodioxol-5-yl)-3,4-dihydroxyhexane-2,5-diyl]bis(2-[[(2S)-3-(tert-butylsulfonyl)-2-(naphthalen-1-ylmethyl)propanoyl]amino]-3-methylbutanamide)
Human immunodeficiency virus 1
-
-
0.000018
(2S,2'S)-N,N'-[(2S,3R,4R,5S)-1,6-bis(2,4-dimethoxyphenyl)-3,4-dihydroxyhexane-2,5-diyl]bis(2-[[(2S)-3-(tert-butylsulfonyl)-2-(naphthalen-1-ylmethyl)propanoyl]amino]-3-methylbutanamide)
Human immunodeficiency virus 1
-
-
0.0000029
(2S,2'S)-N,N'-[(2S,3R,4R,5S)-3,4-dihydroxy-1,6-bis(4-hydroxyphenyl)hexane-2,5-diyl]bis(2-[[(2S)-3-(tert-butylsulfonyl)-2-(naphthalen-1-ylmethyl)propanoyl]amino]-3-methylbutanamide)
Human immunodeficiency virus 1
-
-
0.00000085
(2S,2'S)-N,N'-[(2S,3R,4R,5S)-3,4-dihydroxy-1,6-diphenylhexane-2,5-diyl]bis(2-[[(2S)-2-amino-3-phenylpropanoyl]amino]-3-methylbutanamide)
Human immunodeficiency virus 1
-
-
0.0000032
(2S,2'S)-N,N'-[(2S,3R,4R,5S)-3,4-dihydroxy-1,6-diphenylhexane-2,5-diyl]bis(2-[[(2S)-2-benzyl-3-(tert-butylsulfonyl)propanoyl]amino]-3-methylbutanamide)
Human immunodeficiency virus 1
-
-
0.000022
(2S,2'S)-N,N'-[(2S,3R,4R,5S)-3,4-dihydroxy-1,6-diphenylhexane-2,5-diyl]bis(2-[[(2S)-2-hydroxy-3-phenylpropanoyl]amino]-3-methylbutanamide)
Human immunodeficiency virus 1
-
-
0.00000034
(2S,2'S)-N,N'-[(2S,3R,4R,5S)-3,4-dihydroxy-1,6-diphenylhexane-2,5-diyl]bis(2-[[(2S)-3-(tert-butylsulfonyl)-2-(4-methoxybenzyl)propanoyl]amino]-3-methylbutanamide)
Human immunodeficiency virus 1
-
-
0.0000005
(2S,2'S)-N,N'-[(2S,3R,4R,5S)-3,4-dihydroxy-1,6-diphenylhexane-2,5-diyl]bis(2-[[(2S)-3-(tert-butylsulfonyl)-2-(naphthalen-1-ylmethyl)propanoyl]amino]-3,3-dimethylbutanamide)
Human immunodeficiency virus 1
-
-
0.0000003
(2S,2'S)-N,N'-[(2S,3R,4R,5S)-3,4-dihydroxy-1,6-diphenylhexane-2,5-diyl]bis(2-[[(2S)-3-(tert-butylsulfonyl)-2-(naphthalen-1-ylmethyl)propanoyl]amino]-3-methylbutanamide)
Human immunodeficiency virus 1
-
-
0.0000004
(2S,2'S)-N,N'-[(2S,3R,4R,5S)-3,4-dihydroxy-1,6-diphenylhexane-2,5-diyl]bis(2-[[(2S)-3-(tert-butylsulfonyl)-2-(naphthalen-1-ylmethyl)propanoyl]amino]pentanamide)
Human immunodeficiency virus 1
-
-
0.000004
(2S,2'S)-N,N'-[(2S,3R,4R,5S)-3,4-dihydroxy-1,6-diphenylhexane-2,5-diyl]bis(2-[[3-(tert-butylsulfonyl)propanoyl]amino]-3-methylbutanamide)
Human immunodeficiency virus 1
-
-
0.000038
(2S,2'S)-N,N'-[(2S,3R,4R,5S)-3,4-dihydroxy-1,6-diphenylhexane-2,5-diyl]bis(3-methyl-2-[[(naphthalen-1-yloxy)acetyl]amino]butanamide)
Human immunodeficiency virus 1
-
-
0.000004
(2S,2'S)-N,N'-[(2S,3R,4R,5S)-3,4-dihydroxy-1,6-diphenylhexane-2,5-diyl]bis(3-methyl-2-[[3-(pyridin-4-ylsulfonyl)propanoyl]amino]butanamide)
Human immunodeficiency virus 1
-
-
0.000015
(2S,2'S)-N,N'-[(2S,3R,4R,5S)-3,4-dihydroxy-1,6-diphenylhexane-2,5-diyl]bis(3-methyl-2-[[methyl(pyridin-2-ylmethyl)carbamoyl]amino]butanamide)
Human immunodeficiency virus 1
-
-
0.00034
(2S,2'S)-N,N'-[(2S,3R,4R,5S)-3,4-dihydroxy-1,6-diphenylhexane-2,5-diyl]bis[2-[[(2S)-3-(tert-butylsulfonyl)-2-(naphthalen-1-ylmethyl)propanoyl]amino]-3-(1H-imidazol-4-yl)propanamide]
Human immunodeficiency virus 1
-
-
0.00014
(2S,2'S)-N,N'-[(3S,4R,5R,6S)-4,5-dihydroxy-1,8-di(pyridin-4-yl)octane-3,6-diyl]bis(2-[[(2S)-3-(tert-butylsulfonyl)-2-(naphthalen-1-ylmethyl)propanoyl]amino]-3-methylbutanamide)
Human immunodeficiency virus 1
-
-
0.00036
(2S,2'S)-N,N'-[(3S,4R,5R,6S)-4,5-dihydroxy-1,8-diphenyloctane-3,6-diyl]bis(2-[[(2S)-3-(tert-butylsulfonyl)-2-(naphthalen-1-ylmethyl)propanoyl]amino]-3-methylbutanamide)
Human immunodeficiency virus 1
-
-
0.000001
(2S,2'S)-N,N'-[(6S,7R,8R,9S)-7,8-dihydroxytetradecane-6,9-diyl]bis(2-[[(2S)-3-(tert-butylsulfonyl)-2-(naphthalen-1-ylmethyl)propanoyl]amino]-3-methylbutanamide)
Human immunodeficiency virus 1
-
-
0.0001
(2S,2'S)-N1,N1'-[(2S,3R,4R,5S)-3,4-dihydroxy-1,6-diphenylhexane-2,5-diyl]bis(2-[[(2S)-3-(tert-butylsulfonyl)-2-(naphthalen-1-ylmethyl)propanoyl]amino]butanediamide)
Human immunodeficiency virus 1
-
-
0.000019
(3aR,4R,7aS)-hexahydro-4H-furo[2,3-b]pyran-4-yl [(2S,3R)-3-hydroxy-4-{[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino}-1-phenylbutan-2-yl]carbamate
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.000008
(3aR,7aR)-octahydro-1-benzofuran-4-yl [(2S,3R)-3-hydroxy-4-{[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino}-1-phenylbutan-2-yl]carbamate
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.001
(3aR,7aR)-octahydro-1H-inden-4-yl [(2S,3R)-3-hydroxy-4-{[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino}-1-phenylbutan-2-yl]carbamate
Human immunodeficiency virus 1
-
IC50 above 0.001 mM, pH and temperature not specified in the publication
0.0000005
(3aS,4S,7aR)-hexahydro-4H-furo[2,3-b]pyran-4-yl [(2S,3R)-3-hydroxy-4-{[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino}-1-phenylbutan-2-yl]carbamate
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.0000065
(3aS,4S,7aR)-hexahydro-4H-furo[2,3-b]pyran-4-yl [(2S,3R)-4-{[(4-aminophenyl)sulfonyl](2-methylpropyl)amino}-3-hydroxy-1-phenylbutan-2-yl]carbamate
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.0000045
(3aS,4S,7aR)-hexahydro-4H-furo[2,3-b]pyran-4-yl {(2S,3R)-3-hydroxy-4-[{[4-(hydroxymethyl)phenyl]sulfonyl}(2-methylpropyl)amino]-1-phenylbutan-2-yl}carbamate
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.05
(3R,4aR,8aR)-N-tert-butyl-2-[(R)-2-hydroxy-3-(N-(2-phenylethyl)-4-aminophenylsulfonamido)propyl]decahydroisoquinoline-3-carboxamide
Human immunodeficiency virus 1
-
-
0.38
(3R,4aR,8aR)-N-tert-butyl-2-[(R)-2-hydroxy-3-(N-isobutyl-3-aminophenylsulfonamido)propyl]decahydroisoquinoline-3-carboxamide
Human immunodeficiency virus 1
-
-
0.02
(3R,4aR,8aR)-N-tert-butyl-2-[(R)-2-hydroxy-3-(N-isobutyl-4-aminophenylsulfonamido)propyl]decahydroisoquinoline-3-carboxamide
Human immunodeficiency virus 1
-
-
0.47
(3R,4aR,8aR)-N-tert-butyl-2-[(R)-2-hydroxy-3-(N-propyl-4-aminophenylsulfonamido)propyl]decahydroisoquinoline-3-carboxamide
Human immunodeficiency virus 1
-
-
0.0000014
(3R,6S,9S,10R,11R,12S,15S,18R)-3,9,12,18-tetrabenzyl-10,11-dihydroxy-4,7,14,17-tetraoxo-6,15-di(propan-2-yl)-5,8,13,16-tetraazaicosane-1,20-dioic acid
Human immunodeficiency virus 1
-
-
0.000015
(3S,4aS,8aS)-2-((2R,3S)-4-(benzo[b]thiophen-2-yl)-2-hydroxy-3-(3-hydroxy-2-methylbenzamido)butyl)-N-tert-butyldecahydroisoquinoline-3-carboxamide
Human immunodeficiency virus 1
-
-
0.004
(3S,4aS,8aS)-N-tert-butyl-2-((2R,3R)-2-hydroxy-3-(3-hydroxy-2-methylbenzamido)-3-(4-phenylthiophen-2-yl)propyl)decahydroisoquinoline-3-carboxamide
Human immunodeficiency virus 1
-
-
0.000006
(3S,4aS,8aS)-N-tert-butyl-2-((2R,3S)-2-hydroxy-3-(3-hydroxy-2-methylbenzamido)-4-(4-phenylthiophen-2-yl)butyl)decahydroisoquinoline-3-carboxamide
Human immunodeficiency virus 1
-
-
0.0000029
(3S,4aS,8aS)-N-tert-butyl-2-((2R,3S)-2-hydroxy-3-(3-hydroxy-2-methylbenzamido)-4-(thiophen-2-yl)butyl)decahydroisoquinoline-3-carboxamide
Human immunodeficiency virus 1
-
wild-type protein, with 1 nM: 34% residual activity of wild-type protein, 97% residual activity of V32I mutant protein and 60% residual activity of V82A mutant protein, with 10 nM: 5% residual activity of wild-type protein and 32% residual activity of V32I mutant protein
0.03
(3S,4aS,8aS)-N-tert-butyl-2-[(2R,3S)-2-hydroxy-3-[(3-hydroxy-2-methylbenzoyl)amino]-4-(thiophen-2-yl)butyl]decahydroisoquinoline-3-carboxamide
Human immunodeficiency virus 1
-
-
0.0198
(3S,4S)-3-((benzyl[(2-bromo-4,5-dimethoxyphenyl)carbonyl]amino)methyl)-4-(([2-(2,4-dichlorophenyl)ethyl](4-phenylbutanoyl)amino)methyl)pyrrolidinium
Human immunodeficiency virus 1
-
IC50 is 0.0198 mM, binding structure analysis, modelling
0.0221
(3S,4S)-3-((benzyl[(2-bromo-4,5-dimethoxyphenyl)carbonyl]amino)methyl)-4-(([2-(2,4-dichlorophenyl)ethyl][3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propanoyl]amino)methyl)pyrrolidinium
Human immunodeficiency virus 1
-
IC50 is 0.0221 mM, binding structure analysis, modelling
0.00016
(4-[4-hydroxy-2-oxo-3-[(2-phenylethyl)sulfanyl]-2H-pyran-6-yl]phenoxy)acetic acid
Human immunodeficiency virus 1
-
-
0.001
(4aS,7aR)-hexahydro-2H-furo[3,4-b]pyran-4-yl [(2S,3R)-3-hydroxy-4-{[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino}-1-phenylbutan-2-yl]carbamate
Human immunodeficiency virus 1
-
IC50 above 0.001 mM, pH and temperature not specified in the publication
0.0166
(4R)-4-([[(2S,3R)-4-[[(4-aminophenyl)sulfonyl](2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]carbamoyl]oxy)-L-prolinamide
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.0118
(4R)-4-([[(2S,3R)-4-[[(4-aminophenyl)sulfonyl](2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]carbamoyl]oxy)-N-(2,5-dimethoxyphenyl)-L-prolinamide
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.013
(4R)-4-([[(2S,3R)-4-[[(4-aminophenyl)sulfonyl](2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]carbamoyl]oxy)-N-(2-methoxyphenyl)-L-prolinamide
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.0101
(4R)-4-([[(2S,3R)-4-[[(4-aminophenyl)sulfonyl](2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]carbamoyl]oxy)-N-(3,4,5-trimethoxyphenyl)-L-prolinamide
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.0152
(4R)-4-([[(2S,3R)-4-[[(4-aminophenyl)sulfonyl](2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]carbamoyl]oxy)-N-(3-methoxyphenyl)-L-prolinamide
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.0000154
(4R)-4-([[(2S,3R)-4-[[(4-aminophenyl)sulfonyl](2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]carbamoyl]oxy)-N-(4-methoxyphenyl)-L-prolinamide
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.000139
(4R)-4-([[(2S,3R)-4-[[(4-aminophenyl)sulfonyl](2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]carbamoyl]oxy)-N-(4-methylphenyl)-L-prolinamide
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.0148
(4R)-4-([[(2S,3R)-4-[[(4-aminophenyl)sulfonyl](2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]carbamoyl]oxy)-N-phenyl-L-prolinamide
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.0101
(4R)-4-([[(2S,3R)-4-[[(4-aminophenyl)sulfonyl](2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]carbamoyl]oxy)-N-tert-butyl-L-prolinamide
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.000000008 - 0.00000184
(5S)-3-(3-aminophenyl)-N-[(1S,2R)-3-[(6-benzothiazolylsulfonyl)-(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]-2-oxooxazolidine-5-carboxamide
0.000000006 - 0.00000283
(5S)-3-[3-(acetylamino)phenyl]-N-[(1S,2R)-3-[(6-benzothiazolylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)-propyl]-2-oxooxazolidine-5-carboxamide
0.000000026 - 0.00000187
(5S)-N-[(1S,2R)-3-[(6-benzothiazolylsulfonyl)(2-methylpropyl)-amino]-2-hydroxy-1-((phenylmethyl)propyl)aminocarbonyl]-2-oxo-((3-oxazolidinyl)phenyl)carbamic acid methyl ester
0.000000015 - 0.00000093
(5S)-N-[(1S,2R)-3-[(6-benzothiazolylsulfonyl)(2-methylpropyl)-amino]-2-hydroxy-1-(phenylmethyl)propyl]-3-(3-nitrophenyl)-2-oxooxazolidine-5-carboxamide
0.00000074
(5S,8S,11S,12R,13R,14S,17S)-11,14-dibenzyl-17-[[(2S)-3-(tert-butylsulfonyl)-2-(naphthalen-1-ylmethyl)propanoyl]amino]-8-(2-carboxyethyl)-12,13-dihydroxy-2,2-dimethyl-5-(naphthalen-1-ylmethyl)-6,9,16-trioxo-3l6-thia-7,10,15-triazaicosan-20-oic acid 3,3-dioxide
Human immunodeficiency virus 1
-
-
0.0000073 - 0.00013
(6R)-4-hydroxy-3-[[5-methyl-2-(propan-2-yl)phenyl]sulfanyl]-6-phenyl-6-(2-phenylethyl)-5,6-dihydro-2H-pyran-2-one
0.0000062
(6S)-4-hydroxy-3-[[5-methyl-2-(propan-2-yl)phenyl]sulfanyl]-6-phenyl-6-(2-phenylethyl)-5,6-dihydro-2H-pyran-2-one
Human immunodeficiency virus 1
-
-
0.543
(R)-1-benzyl-3-(1-benzyl-2-oxo-ethyl)-1-piperidin-1-yl-urea
Human immunodeficiency virus 1
-
-
0.0015
(R)-N1-((1R,2R)-3-((3S,4aS,8aS)-3-(tert-butylcarbamoyl)octahydroisoquinolin-2-(1H)-yl)-2-hydroxy-1-(4-phenylthiophen-2-yl)propyl)-2-(quinoline-2-carboxamido)succinamide
Human immunodeficiency virus 1
-
-
0.0000006
(R)-N1-((2S,3R)-1-(benzo[b]thiophen-2-yl)-4-((3S,4aS,8aS)-3-(tert-butylcarbamoyl)octahydroisoquinolin-2(1H)-yl)-3-hydroxybutan-2-yl)-2-(quinoline-2-carboxamido)succinamide
Human immunodeficiency virus 1
-
wild-type protein, with 1 nM: 53% residual activity of wild-type protein, 54% residual activity of V32I mutant protein and 37% residual activity of V82A mutant protein
0.005
(R)-N1-((2S,3R)-4-((3S,4aS,8aS)-3-(tert-butylcarbamoyl)octahydroisoquinolin-2(1H)-yl)-2-hydroxy-1-(thiophen-2-yl)propyl)-2-(quinoline-2-carboxamido)succinamide
Human immunodeficiency virus 1
-
-
0.0000012
(R)-N1-((2S,3R)-4-((3S,4aS,8aS)-3-(tert-butylcarbamoyl)octahydroisoquinolin-2(1H)-yl)-3-hydroxy-1-(4-phenylthiophen-2-yl)butan-2-yl)-2-(quinoline-2-carboxamido)succinamide
Human immunodeficiency virus 1
-
-
0.000021
(R)-N1-((2S,3R)-4-((3S,4aS,8aS)-3-(tert-butylcarbamoyl)octahydroisoquinolin-2(1H)-yl)-3-hydroxy-1-(thiophen-2-yl)butan-2-yl)-2-(quinoline-2-carboxamido)succinamide
Human immunodeficiency virus 1
-
-
0.0372
(S)-1-benzyl-3-(1-benzyl-2-oxo-ethyl)-1-piperidin-1-yl-urea
Human immunodeficiency virus 1
-
-
0.0000003
(S,2S,2'S,3R,3'R)-N,N'-((2S,3R,4R,5S)-3,4-dihydroxy-1,6-diphenylhexane-2,5-diyl)bis(2-((S)-3-(tert-butylsulfonyl)-2-(naphthalen-1-ylmethyl)propanamido)-3-hydroxybutanamide)
Human immunodeficiency virus 1
-
-
0.0000003
(S,2S,2'S,3R,3'R)-N,N'-((2S,3R,4R,5S)-3,4-dihydroxy-1,6-diphenylhexane-2,5-diyl)bis(2-((S)-3-(tert-butylsulfonyl)-2-(naphthalen-1-ylmethyl)propanamido)-3-methylpentanamide)
Human immunodeficiency virus 1
-
-
0.0445
(S,S)-1-[1-benzyl-3-(1-benzyl-2-oxo-ethyl)-ureido]-pyrrolidine-2-carboxylic acid tert-butylamide
Human immunodeficiency virus 1
-
-
0.169
(S,S,S,S)-1-[1-benzyl-3-(1-benzyl-2-oxo-ethyl)-ureido]-pyrrolidine-2-carboxylic acid [1-(1-tert-butylcarbamoyl-2-methyl-propylcarbamoyl)-2-methyl-butyl]-amide
Human immunodeficiency virus 1
-
-
0.341
1-(benzyl[[(2S)-1-oxo-3-phenylpropan-2-yl]carbamoyl]amino)-L-prolyl-N-tert-butyl-L-valinamide
Human immunodeficiency virus 1
-
-
0.101
1-[(1S)-2-methyl-1-[1-[(1S)-1-[1-[(1S)-1-[1-[(1S)-2-methyl-1-[1-[(1R)-1-phenylethyl]-1H-1,2,3-triazol-4-yl]propyl]-1H-1,2,3-triazol-4-yl]-2-phenylethyl]-1H-1,2,3-triazol-4-yl]-2-phenylethyl]-1H-1,2,3-triazol-4-yl]propyl]-4-(2-phenylethyl)-1H-1,2,3-triazole
Human immunodeficiency virus 1
-
-
0.204
1-[(3R)-3-benzyl-3-([N-[(benzyloxy)carbonyl]-L-valyl]amino)-4-oxobutyl]-L-prolyl-N-tert-butyl-L-valinamide
Human immunodeficiency virus 1
-
-
0.545
1-[(3R)-3-benzyl-3-([N-[(benzyloxy)carbonyl]-L-valyl]amino)-4-oxobutyl]-N-tert-butyl-L-prolinamide
Human immunodeficiency virus 1
-
-
0.00000013
1-[2-Hydroxy-4-(2-hydroxy-indan-1-ylcarbamoyl)-5-phenyl-pentyl]-4-(4-oxo-4H-chromene-2-carbonyl)-piperazine-2-carboxylic acid tert-butylamide
Human immunodeficiency virus 1
-
IC50: 0.13 nM
0.000018
1-[2-Hydroxy-4-(2-hydroxy-indan-1-ylcarbamoyl)-5-phenyl-pentyl]-4-(naphthalen-2-yloxy)-pyrrolidine-2-carboxylic acid tert-butylamide
Human immunodeficiency virus 1
-
IC50: 18 nM
0.00000003
1-[2-Hydroxy-4-(2-hydroxy-indan-1-ylcarbamoyl)-5-phenyl-pentyl]-4-(quinoline-8-sulfonyl)-piperazine-2-carboxylic acid tert-butylamide
Human immunodeficiency virus 1
-
IC50: 0.03 nM
0.00000041
1-[2-Hydroxy-4-(2-hydroxy-indan-1-ylcarbamoyl)-5-phenyl-pentyl]-4-pyridin-3-ylmethyl-piperazine-2-carboxylic acid tert-butylamide
Human immunodeficiency virus 1
-
IC50: 0.41 nM
0.000038
1-[2-Hydroxy-4-(2-hydroxy-indan-1-ylcarbamoyl)-5-phenyl-pentyl]-piperazine-2-carboxylic acid tert-butylamide
Human immunodeficiency virus 1
-
IC50: 38 nM
0.00008
1-[2-Hydroxy-4-(2-hydroxy-indan-1-ylcarbamoyl)-5-phenyl-pentyl]-piperidine-2-carboxylic acid tert-butylamide
Human immunodeficiency virus 1
-
IC50: 80 nM
0.00035
1-[2-Hydroxy-4-(2-hydroxy-indan-1-ylcarbamoyl)-5-phenyl-pentyl]-pyrrolidine-2-carboxylic acid tert-butylamide
Human immunodeficiency virus 1
-
IC50: 350 nM
0.019
2'-([4-[3-(4-bromophenyl)propanoyl]phenyl]acetyl)biphenyl-2-carboxylic acid
Human immunodeficiency virus 1
-
-
0.00000089
2,3,4,5,5-pentahydroxy-N-[(2S,5S,8S,9R,10R,11S,14S,17S)-8,11,17-tribenzyl-9,10,20,21,22,23,23-heptahydroxy-3,6,13,16,19-pentaoxo-1-phenyl-5,14-di(propan-2-yl)-4,7,12,15,18-pentaazatricosan-2-yl]pentanamide
Human immunodeficiency virus 1
-
-
0.0000017
2,5-bis[[(2S)-2-[[(2S)-3-(tert-butylsulfonyl)-2-(naphthalen-1-ylmethyl)propanoyl]amino]-2-cyclohexylacetyl]amino]-1,2,5,6-tetradeoxy-1,6-diphenyl-L-iditol
Human immunodeficiency virus 1
-
-
0.0000003
2,5-bis[[(2S)-2-[[(2S)-3-(tert-butylsulfonyl)-2-(naphthalen-1-ylmethyl)propanoyl]amino]-2-cyclopentylacetyl]amino]-1,2,5,6-tetradeoxy-1,6-diphenyl-L-iditol
Human immunodeficiency virus 1
-
-
0.000025
2,6-dimethylphenoxyacetyl-Phe-PSI(S,R,S)[OH]-Phe-2,6-dimethylphenoxyacetyl
Human immunodeficiency virus 1
-
IC50: 25 nM
0.000028
2,6-dimethylphenoxyacetyl-Phe-PSI(S,S,S)[OH]-Phe-2,6-dimethylphenoxyacetyl
Human immunodeficiency virus 1
-
IC50: 28 nM
0.0081
2-(2,5-dichlorobenzoyl)-4,5-dihydroxybenzoic acid
Human immunodeficiency virus 1
-
-
0.029
2-(3,4-dihydroxy-5-oxo-2,5-dihydrofuran-2-yl)-2-hydroxyethyl 5-cyclohexylpentanoate
Human immunodeficiency virus 1
-
-
0.0069
2-(4-chlorophenyl)-7-hydroxyquinoline-4-carboxylic acid
Human immunodeficiency virus 1
-
-
0.0102
2-hydroxy-6-pentadecylbenzoic acid
Human immunodeficiency virus 1
-
-
0.0249
2-hydroxy-6-[(8Z)-pentadec-8-en-1-yl]benzoic acid
Human immunodeficiency virus 1
-
-
0.009
2-hydroxyphenoxyacetyl-Phe-PSI(S,R,S)[OH]-Phe-2-hydroxyphenoxyacetyl
Human immunodeficiency virus 1
-
IC50: 0.009 mM
0.007
2-hydroxyphenoxyacetyl-Phe-PSI(S,S,S)[OH]-Phe-2-hydroxyphenoxyacetyl
Human immunodeficiency virus 1
-
IC50: 0.007 mM
0.017
2-O-acetyldryopteric acid A
Human immunodeficiency virus 1
-
-
0.0108
2-O-acetyldryopteric acid B
Human immunodeficiency virus 1
-
-
0.0178
2-[(10Z)-heptadec-10-en-1-yl]-6-hydroxybenzoic acid
Human immunodeficiency virus 1
-
-
0.0000035
3-(2,5-diethoxyphenylthio)-5,6-dihydro-4-hydroxy-6-((naphthalen-1-yloxy)methyl)-6-phenylpyran-2-one
Human immunodeficiency virus 1
-
in 0.1 M MES, 0.2 M NaCl, 5 mM EDTA, pH 5.5, temperature not specified in the publication
0.0000092
3-(2,5-diethoxyphenylthio)-5,6-dihydro-4-hydroxy-6-((naphthalen-2-yloxy)methyl)-6-phenylpyran-2-one
Human immunodeficiency virus 1
-
in 0.1 M MES, 0.2 M NaCl, 5 mM EDTA, pH 5.5, temperature not specified in the publication
0.000024
3-(2,5-diethoxyphenylthio)-5,6-dihydro-4-hydroxy-6-phenyl-6-((phenylthio)methyl)pyran-2-one
Human immunodeficiency virus 1
-
in 0.1 M MES, 0.2 M NaCl, 5 mM EDTA, pH 5.5, temperature not specified in the publication
0.000126
3-(2,5-dimethylphenylthio)-5,6-dihydro-4-hydroxy-6-((naphthalen-1-yloxy)methyl)-6-phenylpyran-2-one
Human immunodeficiency virus 1
-
in 0.1 M MES, 0.2 M NaCl, 5 mM EDTA, pH 5.5, temperature not specified in the publication
0.000065
3-(2,5-dimethylphenylthio)-5,6-dihydro-4-hydroxy-6-((naphthalen-2-yloxy)methyl)-6-phenylpyran-2-one
Human immunodeficiency virus 1
-
in 0.1 M MES, 0.2 M NaCl, 5 mM EDTA, pH 5.5, temperature not specified in the publication
0.000196
3-(2,5-dimethylphenylthio)-5,6-dihydro-4-hydroxy-6-phenyl-6-((phenylthio)methyl)pyran-2-one
Human immunodeficiency virus 1
-
in 0.1 M MES, 0.2 M NaCl, 5 mM EDTA, pH 5.5, temperature not specified in the publication
0.000059
3-(2-chlorophenylthio)-5,6-dihydro-4-hydroxy-6-((naphthalen-1-yloxy)methyl)-6-phenylpyran-2-one
Human immunodeficiency virus 1
-
in 0.1 M MES, 0.2 M NaCl, 5 mM EDTA, pH 5.5, temperature not specified in the publication
0.000089
3-(2-chlorophenylthio)-5,6-dihydro-4-hydroxy-6-((naphthalen-2-yloxy)methyl)-6-phenylpyran-2-one
Human immunodeficiency virus 1
-
in 0.1 M MES, 0.2 M NaCl, 5 mM EDTA, pH 5.5, temperature not specified in the publication
0.00007
3-(2-chlorophenylthio)-5,6-dihydro-4-hydroxy-6-phenyl-6-((phenylthio)methyl)pyran-2-one
Human immunodeficiency virus 1
-
in 0.1 M MES, 0.2 M NaCl, 5 mM EDTA, pH 5.5, temperature not specified in the publication
0.0001
3-(2-ethylphenylthio)-5,6-dihydro-4-hydroxy-6-((naphthalen-1-yloxy)methyl)-6-phenylpyran-2-one
Human immunodeficiency virus 1
-
in 0.1 M MES, 0.2 M NaCl, 5 mM EDTA, pH 5.5, temperature not specified in the publication
0.000022
3-(2-ethylphenylthio)-5,6-dihydro-4-hydroxy-6-((naphthalen-2-yloxy)methyl)-6-phenylpyran-2-one
Human immunodeficiency virus 1
-
in 0.1 M MES, 0.2 M NaCl, 5 mM EDTA, pH 5.5, temperature not specified in the publication
0.000238
3-(2-ethylphenylthio)-5,6-dihydro-4-hydroxy-6-phenyl-6-((phenylthio)methyl)pyran-2-one
Human immunodeficiency virus 1
-
in 0.1 M MES, 0.2 M NaCl, 5 mM EDTA, pH 5.5, temperature not specified in the publication
0.00026
3-(benzylsulfanyl)-4-hydroxy-6,6-diphenyl-5,6-dihydro-2H-pyran-2-one
Human immunodeficiency virus 1
-
-
0.0017
3-(benzylsulfanyl)-4-hydroxy-6-phenyl-2H-pyran-2-one
Human immunodeficiency virus 1
-
-
0.00006
3-(benzylsulfanyl)-4-hydroxy-6-phenyl-6-(2-phenylethyl)-5,6-dihydro-2H-pyran-2-one
Human immunodeficiency virus 1
-
-
0.000128
3-(benzylthio)-5,6-dihydro-4-hydroxy-6-((naphthalen-1-yloxy)methyl)-6-phenylpyran-2-one
Human immunodeficiency virus 1
-
in 0.1 M MES, 0.2 M NaCl, 5 mM EDTA, pH 5.5, temperature not specified in the publication
0.000073
3-(benzylthio)-5,6-dihydro-4-hydroxy-6-((naphthalen-2-yloxy)methyl)-6-phenylpyran-2-one
Human immunodeficiency virus 1
-
in 0.1 M MES, 0.2 M NaCl, 5 mM EDTA, pH 5.5, temperature not specified in the publication
0.000032
3-(benzylthio)-5,6-dihydro-4-hydroxy-6-phenyl-6-((phenylthio)methyl)pyran-2-one
Human immunodeficiency virus 1
-
in 0.1 M MES, 0.2 M NaCl, 5 mM EDTA, pH 5.5, temperature not specified in the publication
0.000064
3-(o-tolylthio)-5,6-dihydro-4-hydroxy-6-((naphthalen-1-yloxy)methyl)-6-phenylpyran-2-one
Human immunodeficiency virus 1
-
in 0.1 M MES, 0.2 M NaCl, 5 mM EDTA, pH 5.5, temperature not specified in the publication
0.000061
3-(o-tolylthio)-5,6-dihydro-4-hydroxy-6-((naphthalen-2-yloxy)methyl)-6-phenylpyran-2-one
Human immunodeficiency virus 1
-
in 0.1 M MES, 0.2 M NaCl, 5 mM EDTA, pH 5.5, temperature not specified in the publication
0.00024
3-(o-tolylthio)-5,6-dihydro-4-hydroxy-6-phenyl-6-((phenylthio)methyl)pyran-2-one
Human immunodeficiency virus 1
-
in 0.1 M MES, 0.2 M NaCl, 5 mM EDTA, pH 5.5, temperature not specified in the publication
0.12
3-benzyl-4-hydroxy-2H-chromen-2-one
Human immunodeficiency virus 1
-
-
0.0000098
3-[(2-tert-butyl-5-methylphenyl)sulfanyl]-4-hydroxy-6-phenyl-6-(2-phenylethyl)-5,6-dihydro-2H-pyran-2-one
Human immunodeficiency virus 1
-
-
0.000017
3-[(2-tert-butylphenyl)sulfanyl]-4-hydroxy-6-phenyl-2H-pyran-2-one
Human immunodeficiency virus 1
-
-
0.0000036
3-[(2-tert-butylphenyl)sulfanyl]-4-hydroxy-6-phenyl-6-(2-phenylethyl)-5,6-dihydro-2H-pyran-2-one
Human immunodeficiency virus 1
-
-
0.00048
3-[(benzylsulfanyl)(phenyl)methyl]-4-hydroxy-6-phenyl-2H-pyran-2-one
Human immunodeficiency virus 1
-
-
0.000084
3-[1-(benzylsulfanyl)-2-cyclopropylethyl]-4-hydroxy-6-phenyl-2H-pyran-2-one
Human immunodeficiency virus 1
-
-
0.00026
3-[1-(benzylsulfanyl)-3-methylbutyl]-4-hydroxy-6-phenyl-2H-pyran-2-one
Human immunodeficiency virus 1
-
-
0.00015
3-[1-(cyclohexylsulfanyl)-2-cyclopropylethyl]-4-hydroxy-6-phenyl-2H-pyran-2-one
Human immunodeficiency virus 1
-
-
0.000069
3-[1-(cyclopentylsulfanyl)-2-cyclopropylethyl]-4-hydroxy-6-phenyl-2H-pyran-2-one
Human immunodeficiency virus 1
-
-
0.000058
3-[1-(cyclopentylsulfanyl)-3-methylbutyl]-4-hydroxy-6-phenyl-2H-pyran-2-one
Human immunodeficiency virus 1
-
-
0.00023
3-[cyclopentyl(cyclopentylsulfanyl)methyl]-4-hydroxy-6-phenyl-2H-pyran-2-one
Human immunodeficiency virus 1
-
-
0.00052
4,7-dihydroxy-3-[4-(2-methoxyphenyl)butyl]-2H-chromen-2-one
Human immunodeficiency virus 1
-
-
0.023
4-acetylphenoxyacetyl-Phe-PSI(S,R,S)[OH]-Phe-4-acetylphenoxyacetyl
Human immunodeficiency virus 1
-
IC50: 0.023 mM
0.019
4-acetylphenoxyacetyl-Phe-PSI(S,S,S)[OH]-Phe-4-acetylphenoxyacetyl
Human immunodeficiency virus 1
-
IC50: 0.019 mM
2
4-Benzyl-1-[2-hydroxy-4-(2-hydroxy-indan-1-ylcarbamoyl)-5-phenyl-pentyl]-piperazine-2-carboxylic acid tert-butylamide
Human immunodeficiency virus 1
-
IC50: 2.0 mM
0.08
4-formylphenoxyacetyl-Phe-PSI(S,R,S)[OH]-Phe-4-acetylphenoxyacetyl
Human immunodeficiency virus 1
-
IC50: 0.08 mM
0.068
4-formylphenoxyacetyl-Phe-PSI(S,S,S)[OH]-Phe-4-acetylphenoxyacetyl
Human immunodeficiency virus 1
-
IC50: 0.068 mM
0.018
4-hydroxy-3-(3-oxo-1-phenylbutyl)-2H-chromen-2-one
Human immunodeficiency virus 1
-
-
0.0023
4-hydroxy-3-(3-phenoxypropyl)-2H-chromen-2-one
Human immunodeficiency virus 1
-
-
0.11
4-hydroxy-3-(4-phenylbutyl)-2H-chromen-2-one
Human immunodeficiency virus 1
-
-
0.00042
4-hydroxy-3-[(2-methylphenyl)sulfanyl]-6-phenyl-2H-pyran-2-one
Human immunodeficiency virus 1
-
-
0.000073
4-hydroxy-3-[(2-methylphenyl)sulfanyl]-6-phenyl-6-(2-phenylethyl)-5,6-dihydro-2H-pyran-2-one
Human immunodeficiency virus 1
-
-
0.026
4-hydroxy-3-[3-(phenylsulfanyl)propyl]-2H-chromen-2-one
Human immunodeficiency virus 1
-
-
0.00041
4-hydroxy-3-[3-methyl-1-(phenylsulfanyl)butyl]-6-phenyl-2H-pyran-2-one
Human immunodeficiency virus 1
-
-
0.0017
4-hydroxy-3-[4-(2-methoxyphenyl)butyl]-2H-chromen-2-one
Human immunodeficiency virus 1
-
-
0.000096
4-hydroxy-6-(3-methylbutyl)-6-phenyl-3-[(2-phenylethyl)sulfanyl]-5,6-dihydro-2H-pyran-2-one
Human immunodeficiency virus 1
-
-
0.000007
4-hydroxy-6-(3-methylphenyl)-3-[[2-(propan-2-yl)phenyl]sulfanyl]-2H-pyran-2-one
Human immunodeficiency virus 1
-
-
0.00052
4-hydroxy-6-(4-hydroxyphenyl)-3-[(2-phenylethyl)sulfanyl]-2H-pyran-2-one
Human immunodeficiency virus 1
-
-
0.000084
4-hydroxy-6-pentyl-6-phenyl-3-[(2-phenylethyl)sulfanyl]-5,6-dihydro-2H-pyran-2-one
Human immunodeficiency virus 1
-
-
0.003
4-hydroxy-6-phenyl-3-(phenylsulfanyl)-2H-pyran-2-one
Human immunodeficiency virus 1
-
-
0.0013
4-hydroxy-6-phenyl-3-[(2-phenylethyl)sulfanyl]-2H-pyran-2-one
Human immunodeficiency virus 1
-
-
0.0021
4-hydroxy-6-phenyl-3-[(2-phenylethyl)sulfanyl]-5,6-dihydro-2H-pyran-2-one
Human immunodeficiency virus 1
-
-
0.0051
4-hydroxy-6-phenyl-3-[(2-phenylethyl)sulfanyl]-6-propyl-5,6-dihydro-2H-pyran-2-one
Human immunodeficiency virus 1
-
-
0.00078
4-hydroxy-6-phenyl-3-[phenyl(phenylsulfanyl)methyl]-2H-pyran-2-one
Human immunodeficiency virus 1
-
-
0.000037
4-hydroxy-6-phenyl-3-[[2-(propan-2-yl)phenyl]sulfanyl]-2H-pyran-2-one
Human immunodeficiency virus 1
-
-
0.00013
4-hydroxy-6-phenyl-6-(2-phenylethyl)-3-(phenylsulfanyl)-5,6-dihydro-2H-pyran-2-one
Human immunodeficiency virus 1
-
-
0.000014
4-hydroxy-6-phenyl-6-(2-phenylethyl)-3-[[2-(propan-2-yl)phenyl]sulfanyl]-5,6-dihydro-2H-pyran-2-one
Human immunodeficiency virus 1
-
-
0.0019
4-hydroxy-7,8-dimethyl-3-(3-oxo-1-phenylbutyl)-2H-chromen-2-one
Human immunodeficiency virus 1
-
-
0.0000001
4-oxo-4H-chromene-2-carboxylic acid (1-{1-benzyl-3-[3-benzyl-1-(2-hydroxy-5-methyl-cyclopentyl)-2-oxo-pyrrolidin-3-yl]-2-hydroxy-propylcarbamoyl}-2-methyl-propyl)-amide
Human immunodeficiency virus 1
-
IC50: 0.1 nM
0.000159
5,6-dihydro-4-hydroxy-6-((naphthalen-1-yloxy)methyl)-6-phenyl-3-(phenylthio)pyran-2-one
Human immunodeficiency virus 1
-
in 0.1 M MES, 0.2 M NaCl, 5 mM EDTA, pH 5.5, temperature not specified in the publication
0.000126
5,6-dihydro-4-hydroxy-6-((naphthalen-2-yloxy)methyl)-6-phenyl-3-(phenylthio)pyran-2-one
Human immunodeficiency virus 1
-
in 0.1 M MES, 0.2 M NaCl, 5 mM EDTA, pH 5.5, temperature not specified in the publication
0.000258
5,6-dihydro-4-hydroxy-6-phenyl-3-(phenylthio)-6-((phenylthio)methyl)pyran-2-one
Human immunodeficiency virus 1
-
in 0.1 M MES, 0.2 M NaCl, 5 mM EDTA, pH 5.5, temperature not specified in the publication
0.029
5-(3-chlorobenzyl)-1,2-dihydro-3H-pyrazol-3-one
Human immunodeficiency virus 1
-
-
0.0058
5-tridecylbenzene-1,3-diol
Human immunodeficiency virus 1
-
-
0.0026
5-[(8Z)-pentadec-8-en-1-yl]benzene-1,3-diol
Human immunodeficiency virus 1
-
-
0.000005
5-[4-hydroxy-6-oxo-2-phenyl-5-[(2-phenylethyl)sulfanyl]-3,6-dihydro-2H-pyran-2-yl]pentanoic acid
Human immunodeficiency virus 1
-
-
0.19
Ac-HMSFNL
Human immunodeficiency virus 1
-
IC50: 0.19 mM
0.44
Ac-QIGMTLNF
Human immunodeficiency virus 1
-
IC50: 0.44 mM
1.5
Ac-TLNF
Human immunodeficiency virus 1
-
IC50: 1.5 mM
2
Ac-TLNF-NH2
Human immunodeficiency virus 1
-
IC50 is above 2 mM
0.08
Ac-TVSFNF
Human immunodeficiency virus 1
-
IC50: 0.08 mM
0.00009
acetyl-pepstatin
Human immunodeficiency virus 1
-
-
0.87
Arg-Leu-Asn-Phe
Human immunodeficiency virus 1
-
IC50: 0.87 mM
0.0000178 - 0.072
ATBI
0.000002
benzyl [(5S,8S,9R,10R,11S,14S)-8,11-dibenzyl-9,10-dihydroxy-15-methyl-3,6,13-trioxo-1-phenyl-5-(propan-2-yl)-2-oxa-4,7,12-triazahexadecan-14-yl]carbamate
Human immunodeficiency virus 1
-
-
0.000000008 - 0.000000025
darunavir
0.0265
dryopteric acid A
Human immunodeficiency virus 1
-
-
0.0445
dryopteric acid B
Human immunodeficiency virus 1
-
-
0.41
IGRNLLTQIGCTLNF
Human immunodeficiency virus 1
-
IC50: 0.41 mM
0.0000013 - 0.0015
indinavir
0.0000063
KVS-1
Human immunodeficiency virus 1
-
-
0.000003
Kyn-(D-alpha-(2-thienyl)glycine)-Phe-PSI(S,R,S)[OH]-Phe-2,6-dimethylphenoxyacetyl
Human immunodeficiency virus 1
-
IC50: 3 nM
0.000004
Kyn-Thr-Phe-PSI(S,R,S)[OH]-Phe-2,6-dimethylphenoxyacetyl
Human immunodeficiency virus 1
-
IC50: 4 nM
0.000003
Kyn-Val-Phe-PSI(S,R,S)[OH]-Phe-2,6-dimethylphenoxyacetyl
Human immunodeficiency virus 1
-
IC50: 3 nM
0.000004
Kyn-Val-Phe-PSI(S,R,S)[OH]-Phe-Val-Kyn
Human immunodeficiency virus 1
-
IC50: 4 nM
0.000003
Kyn-Val-Phe-PSI(S,S,S)[OH]-Phe-2,6-dimethylphenoxyacetyl
Human immunodeficiency virus 1
-
IC50: 3 nM
0.67
L-700,417
Human immunodeficiency virus 1
-
IC50: 0.67 mM
0.0000078
L-704,486
Human immunodeficiency virus 1
-
IC50: 7.8 nM
0.00000009 - 0.0000009
lopinavir
0.0389
manassantin A
Human immunodeficiency virus 1
-
-
0.0106 - 0.0172
methyl 4-[([6-[([4-[(tert-butoxycarbonyl)amino]thiophen-2-yl]carbonyl)amino]-1,3-benzoxazol-2-yl]carbonyl)amino]thiophene-2-carboxylate
0.0000024
morpholine-4-carboxylic acid (1-{1-benzyl-3-[3-benzyl-1-(2-hydroxy-5-methyl-cyclopentyl)-2-oxo-pyrrolidin-3-yl]-2-hydroxy-propylcarbamoyl}-2-methyl-propyl)-amide
Human immunodeficiency virus 1
-
IC50: 2.4 nM
0.00000079
N,N'-[(2S,3R,4R,5S)-3,4-dihydroxy-1,6-diphenylhexane-2,5-diyl]bis(2-[[(2S)-3-(tert-butylsulfonyl)-2-(pyridin-4-ylmethyl)propanoyl]amino]-3-methylbutanamide)
Human immunodeficiency virus 1
-
-
0.0000013
N-(1-{1-benzyl-3-[3-benzyl-1-(2-hydroxy-5-methyl-cyclopentyl)-2-oxo-pyrrolidin-3-yl]-2-hydroxy-propylcarbamoyl}-2-methyl-propyl)-isonicotinamide
Human immunodeficiency virus 1
-
IC50: 1.3 nM
0.0000008
N-(1-{1-benzyl-3-[3-benzyl-1-(2-hydroxy-5-methyl-cyclopentyl)-2-oxo-pyrrolidin-3-yl]-2-hydroxy-propylcarbamoyl}-2-methyl-propyl)-nicotinamide
Human immunodeficiency virus 1
-
IC50: 0.8 nM
0.0000004
N-[(2R,6S)-6-[[(4-aminophenyl)sulfonyl](3-methylbutyl)amino]-7-hydroxyheptan-2-yl]-Nalpha-(methoxycarbonyl)-beta-phenyl-L-phenylalaninamide
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.000000007
N-[(2S,6S)-6-[[(4-aminophenyl)sulfonyl](3-methylbutyl)amino]-7-hydroxyheptan-2-yl]-Nalpha-(methoxycarbonyl)-beta-phenyl-L-phenylalaninamide
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.000000013
N-[(3S,7S)-7-[[(4-aminophenyl)sulfonyl](3-methylbutyl)amino]-1,8-dihydroxyoctan-3-yl]-Nalpha-(methoxycarbonyl)-beta-phenyl-L-phenylalaninamide
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.0000001
N-[(3S,7S)-7-[[(4-aminophenyl)sulfonyl](3-methylbutyl)amino]-8-hydroxy-2-methyloctan-3-yl]-Nalpha-(methoxycarbonyl)-beta-phenyl-L-phenylalaninamide
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.000000016
N-[(3S,7S)-7-[[(4-aminophenyl)sulfonyl](3-methylbutyl)amino]-8-hydroxyoctan-3-yl]-Nalpha-(methoxycarbonyl)-beta-phenyl-L-phenylalaninamide
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.0000001
N-[(4S,8S)-8-[[(4-aminophenyl)sulfonyl](3-methylbutyl)amino]-9-hydroxynonan-4-yl]-Nalpha-(methoxycarbonyl)-beta-phenyl-L-phenylalaninamide
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.0000005
N-[(5S)-5-[[(4-aminophenyl)sulfonyl](2-methylpropyl)amino]-6-hydroxyhexyl]-Nalpha-(methoxycarbonyl)-beta-phenyl-L-phenylalaninamide
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.00000003
N-[(5S)-5-[[(4-aminophenyl)sulfonyl](3-methylbutyl)amino]-6-hydroxyhexyl]-Nalpha-(methoxycarbonyl)-beta-phenyl-L-phenylalaninamide
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.0000019 - 0.00024
nelfinavir
0.000041
pepstatin
Human immunodeficiency virus 1
-
-
0.017
phenoxyacetyl-Phe-PSI(S,R,S)[OH]-Phe-phenoxyacetyl
Human immunodeficiency virus 1
-
IC50: 0.017 mM
0.005
phenoxyacetyl-Phe-PSI(S,S,S)[OH]-Phe-phenoxyacetyl
Human immunodeficiency virus 1
-
IC50: 0.005 mM
0.0000013
pyridin-3-ylmethyl [(5S,8S,9R,10R,11S,14S)-8,11-dibenzyl-9,10-dihydroxy-15-methyl-3,6,13-trioxo-5-(propan-2-yl)-1-(pyridin-3-yl)-2-oxa-4,7,12-triazahexadecan-14-yl]carbamate
Human immunodeficiency virus 1
-
-
0.0000046
pyridine-2-carboxylic acid (1-{1-benzyl-3-[3-benzyl-1-(2-hydroxy-5-methyl-cyclopentyl)-2-oxo-pyrrolidin-3-yl]-2-hydroxy-propylcarbamoyl}-2-methyl-propyl)-amide
Human immunodeficiency virus 1
-
IC50: 4.6 nM
0.0121
rac-(3S,4S)-N-benzyl-2-(2,6-dimethyl-phenoxy)-N-4-[[(isobutyl-(toluene-4-sulfonyl)-amino)-methyl]-pyrrolidin-3-ylmethyl]-acetamide
Human immunodeficiency virus 1
-
IC50 is 0.0121 mM, binding structure analysis, modelling
0.0033
rac-(3S,4S)-N-[4-([4-amino-benzenesulfonyl-isobutyl-amino]-methyl)-pyrrolidin-3-ylmethyl]-N-benzyl-2-(2,6-dimethyl-phenoxy)-acetamide
Human immunodeficiency virus 1
-
IC50 is 0.0033 mM, binding structure analysis, modelling
0.0022
rac-(3S,4S)-N-[4-([benzenesulfonyl-isobutyl-amino]-methyl)-pyrrolidin-3-ylmethyl]-N-benzyl-2-(2,6-dimethyl-phenoxy)-acetamide
Human immunodeficiency virus 1
-
IC50 is 0.0022 mM, binding structure analysis, modelling
0.00000125 - 0.00025
ritonavir
0.8
RTLNLGL
Human immunodeficiency virus 1
-
IC50 is above 0.8 mM
0.00000012 - 0.000012
saquinavir
0.0056
saururin B
Human immunodeficiency virus 1
-
-
0.47
Ser-Leu-Asn-Phe
Human immunodeficiency virus 1
-
IC50: 0.47 mM
0.28
SFNL
Human immunodeficiency virus 1
-
IC50: 0.28 mM
0.31
SFNLE
Human immunodeficiency virus 1
-
IC50: 0.31 mM
0.38
Thr-Leu-Asn-Leu
Human immunodeficiency virus 1
-
IC50: 0.38 mM
2
Thr-Leu-Asn-Phe-NH2
Human immunodeficiency virus 1
-
IC50 is above 2 mM
1
Thr-Leu-Asn-Tyr
Human immunodeficiency virus 1
-
IC50 is about 1 mM
0.45
Thr-Phe-Asn-Phe
Human immunodeficiency virus 1
-
IC50: 0.45 mM
0.00003
tipranavir
Human immunodeficiency virus 1
-
IC50 is 30 nM, interacts with residues Asp25 and Asp25', and Ile50 and Ile50'
0.8
TLNLGF
Human immunodeficiency virus 1
-
IC50 is above 0.8 mM
0.0089
ursolic acid
Human immunodeficiency virus 1
-
-
0.00075
[1-(1-{1-benzyl-3-[2-(1-tert-butylcarbamoyl-2-methyl-butylcarbamoyl)-pyrrolidin-1-yl]-2-methoxy-propylcarbamoyl}-2-carbamoyl-ethylcarbamoyl)-3-methyl-butyl]-carbamic acid benzyl ester
Human immunodeficiency virus 1
-
IC50: 750 nM
0.00000055
[1-Benzyl-2-hydroxy-4-(3-hydroxy-indan-1-ylcarbamoyl)-7-phenyl-hept-6-enyl]-carbamic acid tert-butyl ester
Human immunodeficiency virus 1
-
IC50: 0.55 nM
0.000111
[1-Benzyl-3-(3-benzyl-1-isothiochroman-4-yl-2-oxo-pyrrolidin-3-yl)-2-hydroxy-propyl]-carbamic acid tert-butyl ester
Human immunodeficiency virus 1
-
IC50: 111 nM
0.000017
[1-Benzyl-3-[3-benzyl-1-(2-hydroxy-5-methyl-cyclopentyl)-2-oxo-pyrrolidin-3-yl]-2-hydroxy-propyl]-carbamic acid tert-butyl ester
Human immunodeficiency virus 1
-
IC50: 17 nM
0.0000023
[1-Benzyl-4-(2,2-dioxo-2lambda6-isothiochroman-4-ylcarbamoyl)-2-hydroxy-7-phenyl-hept-6-enyl]-carbamic acid tert-butyl ester
Human immunodeficiency virus 1
-
IC50: 2.3 nM
0.000014
{1-benzyl-3-[3-benzyl-1-(2,2-dioxo-2l6-isothiochroman-4-yl)-2-oxo-pyrrolidin-3-yl]-2-hydroxy-propyl}-carbamic acid tert-butyl ester
Human immunodeficiency virus 1
-
IC50: 14 nM
0.000018
{1-[1-benzyl-3-(2-tert-butylcarbamoyl-piperidin-1-yl)-2-methoxy-propylcarbamoyl]-2-carbamoyl-ethyl}-carbamic acid benzyl ester
Human immunodeficiency virus 1
-
IC50: 18 nM
0.00021
{1-[1-benzyl-3-(2-tert-butylcarbamoyl-pyrrolidin-1-yl)-2-methoxy-propylcarbamoyl]-2-carbamoyl-ethyl}-carbamic acid benzyl ester
Human immunodeficiency virus 1
-
IC50: 210 nM
additional information
3-(4,8-dimethyl-3,7-nonadienyl)-(5R)-(2,5-dihydroxyphenyl)-2(5H)-furanone