3.4.22.B75: SENP7 peptidase

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For detailed information about SENP7 peptidase, go to the full flat file.

Reaction

Protease that deconjugates SUMO2 and SUMO3 from targeted proteins, but not SUMO1. Catalyzes the deconjugation of poly-SUMO2 and poly-SUMO3 chains. Has very low efficiency in processing full-length SUMO proteins to their mature forms. SENP67 prefers the LRGG-/- sequence versus the QTGG-/- sequence. =

Synonyms

SENP7, SENP7 SUMO-protease, sentrin-specific protease 7, sentrin/small ubiquitin-like modifier-specific protease 7, SUMO protease SENP7, SUMO-specific protease 7, SUMO-specific protease SENP7, SUMO/sentrin/Smt3-specific peptidase

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.22 Cysteine endopeptidases

                3.4.22.B75 SENP7 peptidase

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Results	in table
2	Activating Compound
2	AA Sequence
3	Application
5	Cloned(Commentary)
1	Crystallization (Commentary)
1	Expression
23	General Information
8	Localization
8	Natural Substrates/ Products (Substrates)
14	Organism
3	pH Optimum
10	Protein Variants
2	Purification (Commentary)
1	Reaction
14	Reference
19	Source Tissue
30	Substrates and Products (Substrate)
13	Synonyms
3	Temperature Optimum [°C]

Expression

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Expression on EC 3.4.22.B75 - SENP7 peptidase

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EXPRESSION

ORGANISM

UNIPROT

LITERATURE

SENP7S is the predominant SENP transcript in human mammary epithelia but is significantly reduced in precancerous ductal carcinoma in situ and all breast cancer subtypes. Like other SENP family members, SENP7S has SUMO isopeptidase activity but unlike full-length SENP7L, SENP7S is localized in the cytosol

Homo sapiens

Q9BQF6

755475