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3.4.22.B75: SENP7 peptidase

This is an abbreviated version!
For detailed information about SENP7 peptidase, go to the full flat file.

Word Map on EC 3.4.22.B75

Reaction

Protease that deconjugates SUMO2 and SUMO3 from targeted proteins, but not SUMO1. Catalyzes the deconjugation of poly-SUMO2 and poly-SUMO3 chains. Has very low efficiency in processing full-length SUMO proteins to their mature forms. SENP67 prefers the LRGG-/- sequence versus the QTGG-/- sequence. =

Synonyms

SENP7, SENP7 SUMO-protease, sentrin-specific protease 7, sentrin/small ubiquitin-like modifier-specific protease 7, SUMO protease SENP7, SUMO-specific protease 7, SUMO-specific protease SENP7, SUMO/sentrin/Smt3-specific peptidase

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.B75 SENP7 peptidase

Reference

topprint

Reference on EC 3.4.22.B75 - SENP7 peptidase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Drag, M.; Mikolajczyk, J.; Krishnakumar, I.M.; Huang, Z.; Salvesen, G.S.
Activity profiling of human deSUMOylating enzymes (SENPs) with synthetic substrates suggests an unexpected specificity of two newly characterized members of the family
Biochem. J.
409
461-469
2008
Homo sapiens
Manually annotated by BRENDA team
Shen, L.N.; Geoffroy, M.C.; Jaffray, E.G.; Hay, R.T.
Characterization of SENP7, a SUMO-2/3-specific isopeptidase
Biochem. J.
421
223-230
2009
Homo sapiens
Manually annotated by BRENDA team
Lima, C.D.; Reverter, D.
Structure of the human SENP7 catalytic domain and poly-SUMO deconjugation activities for SENP6 and SENP7
J. Biol. Chem.
283
32045-32055
2008
Homo sapiens (Q9BQF6)
Manually annotated by BRENDA team
Gonzalez-Prieto, R.; Cuijpers, S.A.; Kumar, R.; Hendriks, I.A.; Vertegaal, A.C.
c-Myc is targeted to the proteasome for degradation in a SUMOylation-dependent manner, regulated by PIAS1, SENP7 and RNF4
Cell Cycle
14
1859-1872
2015
Homo sapiens
Manually annotated by BRENDA team
Romeo, K.; Louault, Y.; Cantaloube, S.; Loiodice, I.; Almouzni, G.; Quivy, J.
The SENP7 SUMO-protease presents a module of two HP1 interaction motifs that locks HP1 protein at pericentric heterochromatin
Cell Rep.
10
771-782
2015
Mus musculus
Manually annotated by BRENDA team
Garvin, A.J.; Densham, R.M.; Blair-Reid, S.A.; Pratt, K.M.; Stone, H.R.; Weekes, D.; Lawrence, K.J.; Morris, J.R.
The deSUMOylase SENP7 promotes chromatin relaxation for homologous recombination DNA repair
EMBO Rep.
14
975-983
2013
Homo sapiens
Manually annotated by BRENDA team
Maison, C.; Romeo, K.; Bailly, D.; Dubarry, M.; Quivy, J.P.; Almouzni, G.
The SUMO protease SENP7 is a critical component to ensure HP1 enrichment at pericentric heterochromatin
Nat. Struct. Mol. Biol.
19
458-460
2012
Mus musculus
Manually annotated by BRENDA team
Bawa-Khalfe, T.; Lu, L.S.; Zuo, Y.; Huang, C.; Dere, R.; Lin, F.M.; Yeh, E.T.
Differential expression of SUMO-specific protease 7 variants regulates epithelial-mesenchymal transition
Proc. Natl. Acad. Sci. USA
109
17466-17471
2012
Homo sapiens
Manually annotated by BRENDA team
Alegre, K.O.; Reverter, D.
Structural insights into the SENP6 loop1 structure in complex with SUMO2
Protein Sci.
23
433-441
2014
Homo sapiens
Manually annotated by BRENDA team
Ji, P.; Liang, S.; Li, P.; Xie, C.; Li, J.; Zhang, K.; Zheng, X.; Feng, M.; Li, Q.; Jiao, H.; Chi, X.; Zhao, W.; Zhang, S.; Wang, X.
Speckle-type POZ protein suppresses hepatocellular carcinoma cell migration and invasion via ubiquitin-dependent proteolysis of SUMO1/sentrin specific peptidase 7
Biochem. Biophys. Res. Commun.
502
30-42
2018
Homo sapiens (Q9BQF6)
Manually annotated by BRENDA team
Juarez-Vicente, F.; Luna-Pelaez, N.; Garcia-Dominguez, M.
The Sumo protease Senp7 is required for proper neuronal differentiation
Biochim. Biophys. Acta
1863
1490-1498
2016
Mus musculus (Q8BUH8)
Manually annotated by BRENDA team
Huang, C.J.; Wu, D.; Jiao, X.F.; Khan, F.A.; Xiong, C.L.; Liu, X.M.; Yang, J.; Yin, T.L.; Huo, L.J.
Maternal SENP7 programs meiosis architecture and embryo survival in mouse
Biochim. Biophys. Acta
1864
1195-1206
2017
Mus musculus (Q8BUH8)
Manually annotated by BRENDA team
Cui, Y.; Yu, H.; Zheng, X.; Peng, R.; Wang, Q.; Zhou, Y.; Wang, R.; Wang, J.; Qu, B.; Shen, N.; Guo, Q.; Liu, X.; Wang, C.
SENP7 potentiates cGAS activation by relieving SUMO-mediated inhibition of cytosolic DNA sensing
PLoS Pathog.
13
e1006156
2017
Homo sapiens (Q9BQF6)
Manually annotated by BRENDA team
Karami, S.; Lin, F.M.; Kumar, S.; Bahnassy, S.; Thangavel, H.; Quttina, M.; Li, Y.; Ren, J.; Bawa-Khalfe, T.
Novel SUMO-protease SENP7S regulates beta-catenin signaling and mammary epithelial cell transformation
Sci. Rep.
7
46477
2017
Homo sapiens (Q9BQF6)
Manually annotated by BRENDA team