3.4.22.B75: SENP7 peptidase
This is an abbreviated version!
For detailed information about SENP7 peptidase, go to the full flat file.
Word Map on EC 3.4.22.B75
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3.4.22.B75
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senp7s
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hp1
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heterochromatin
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medicine
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deconjugation
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h3k9me3
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pericentric
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desumoylation
- 3.4.22.B75
- senp7s
- hp1
-
heterochromatin
- medicine
-
deconjugation
-
h3k9me3
-
pericentric
-
desumoylation
Reaction
Protease that deconjugates SUMO2 and SUMO3 from targeted proteins, but not SUMO1. Catalyzes the deconjugation of poly-SUMO2 and poly-SUMO3 chains. Has very low efficiency in processing full-length SUMO proteins to their mature forms. SENP67 prefers the LRGG-/- sequence versus the QTGG-/- sequence. =
Synonyms
SENP7, SENP7 SUMO-protease, sentrin-specific protease 7, sentrin/small ubiquitin-like modifier-specific protease 7, SUMO protease SENP7, SUMO-specific protease 7, SUMO-specific protease SENP7, SUMO/sentrin/Smt3-specific peptidase
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Application on EC 3.4.22.B75 - SENP7 peptidase
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medicine
increased degradation of SENP7 by overexpression of SPOP decreases vimentin levels, which in turn may attenuate hepatocellular carcinoma cell metastasis
medicine
SENP7 is significantly up-regulated in patients with systemic lupus erythematosus
medicine
SENP7S is the predominant SENP transcript in human mammary epithelia but is significantly reduced in precancerous ductal carcinoma in situ and all breast cancer subtypes