3.4.22.B75: SENP7 peptidase

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For detailed information about SENP7 peptidase, go to the full flat file.

Reaction

Protease that deconjugates SUMO2 and SUMO3 from targeted proteins, but not SUMO1. Catalyzes the deconjugation of poly-SUMO2 and poly-SUMO3 chains. Has very low efficiency in processing full-length SUMO proteins to their mature forms. SENP67 prefers the LRGG-/- sequence versus the QTGG-/- sequence. =

Synonyms

SENP7, SENP7 SUMO-protease, sentrin-specific protease 7, sentrin/small ubiquitin-like modifier-specific protease 7, SUMO protease SENP7, SUMO-specific protease 7, SUMO-specific protease SENP7, SUMO/sentrin/Smt3-specific peptidase

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.22 Cysteine endopeptidases

                3.4.22.B75 SENP7 peptidase

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Results	in table
2	Activating Compound
2	AA Sequence
3	Application
5	Cloned(Commentary)
1	Crystallization (Commentary)
1	Expression
23	General Information
8	Localization
8	Natural Substrates/ Products (Substrates)
14	Organism
3	pH Optimum
10	Protein Variants
2	Purification (Commentary)
1	Reaction
14	Reference
19	Source Tissue
30	Substrates and Products (Substrate)
13	Synonyms
3	Temperature Optimum [°C]

Natural Substrates Products

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Natural Substrates Products on EC 3.4.22.B75 - SENP7 peptidase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

poly-SUMO-2 + H2O

?

Homo sapiens

-

the C-terminal catalytic domain of SENP7 efficiently depolymerized poly-SUMO-2 chains but has undetectable activity against poly-SUMO-1 chains

714083

-

-

?

SUMO1-HP1 + H2O

HP1 + SUMO1

Mus musculus

-

deSUMOylation

731614

-

-

?

SUMO2/3ylated HP1alpha + H2O

HP1alpha + SUMO3 + SUMO2

Homo sapiens

-

HP1alpha localizes at the pericentric heterochromatin, importance of SUMOylation in directing HP1alpha’s subnuclear localization, SUMO deconjugation by enzyme SENP7

732812

-

-

?

SUMOylated c-Myc + H2O

deSUMOylated c-Myc + SUMO

Homo sapiens

-

-

731599

-

-

?

SUMOylated HP1alpha + H2O

HP1alpha + SUMO

Mus musculus

-

SUMO deconjugation by enzyme SENP7

732566

-

-

?

SUMOylated KRAB-associated protein 1 + H2O

KRAB-associated protein 1 + SUMO 2 + SUMO3

Homo sapiens

-

enzyme SENP7 promotes the removal of SUMO2/3 from KRAB-associated protein 1

731715

-

-

?

additional information

?

-

2 entries

additional information

?

-

Homo sapiens

-

the enzyme SENP7 interacts with the chromatin repressive KRAB-associated protein 1 through heterochromatin protein 1 alpha, HP1alapha. Enzyme SENP7 contains a conserved HP1-box, PxVxL, required for interaction with HP1

731715

-

-

?

additional information

?

-

Mus musculus

-

a module of two PxVxL HP1 interaction motifs on enzyme SENP7 mediates association with HP1, molecular basis for the interaction between SENP7 and HP1, the capacity for SENP7 to interact with HP1 in cells and its capacity to de-SUMOylate SUMO1-HP1 are independent

731614

-

-

?