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3.4.22.B75: SENP7 peptidase

This is an abbreviated version!
For detailed information about SENP7 peptidase, go to the full flat file.

Word Map on EC 3.4.22.B75

Reaction

Protease that deconjugates SUMO2 and SUMO3 from targeted proteins, but not SUMO1. Catalyzes the deconjugation of poly-SUMO2 and poly-SUMO3 chains. Has very low efficiency in processing full-length SUMO proteins to their mature forms. SENP67 prefers the LRGG-/- sequence versus the QTGG-/- sequence. =

Synonyms

SENP7, SENP7 SUMO-protease, sentrin-specific protease 7, sentrin/small ubiquitin-like modifier-specific protease 7, SUMO protease SENP7, SUMO-specific protease 7, SUMO-specific protease SENP7, SUMO/sentrin/Smt3-specific peptidase

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.B75 SENP7 peptidase

Engineering

Engineering on EC 3.4.22.B75 - SENP7 peptidase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
C745K
mutation does not alter deconjugation rates in comparison with wild-type SENP7
C992A
-
site-directed mutagenesis, inactive catalytic mutant
F709W
end point deconjugation reactions using di-SUMO2/3 or poly-SUMO2/3 reveales rates equivalent to or slightly greater than wild-type SENP7. Mutation results in a 2fold higher activity when di-SUMO2 deconjugation rates are measured
V713E
mutation elicits 65-fold reduction in deconjugation rate compared to wild-type activity
V713E/C745K
C745K substitution partially rescues defects observed for SENP7-V713E when present as a double point substitution (SENP7-V713E/C745K)
C979S
-
site-directed mutagenesis
additional information