3.4.22.B60: cathepsin L2

This is an abbreviated version!
For detailed information about cathepsin L2, go to the full flat file.

Reaction

preference for Arg in the P1 position, Pro is accepted in the P2 position =

Synonyms

cathepsin L2, cathepsin L2 protease, CatL2, CL2, FhCatL2, FhCL2, FhpCL2

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.22 Cysteine endopeptidases

                3.4.22.B60 cathepsin L2

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Results	in table
1	Activating Compound
4	AA Sequence
2	Application
5	Cloned(Commentary)
40	Disease/ Diagnostics
2	Expression
6	General Information
8	Inhibitors
8	kcat/KM [mM/s]
4	Ki Value [mM]
33	KM Value [mM]
4	Localization
4	Molecular Weight [Da]
14	Natural Substrates/ Products (Substrates)
1	Organic Solvent Stability
155	Organism
1	pH Optimum
3	Posttranslational Modification
1	Protein Variants
6	Purification (Commentary)
1	Reaction
16	Reference
1	Renatured (Commentary)
10	Source Tissue
2	Specific Activity [micromol/min/mg]
48	Substrates and Products (Substrate)
4	Subunits
17	Synonyms
1	Temperature Optimum [°C]
33	Turnover Number [1/s]

Disease

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Disease on EC 3.4.22.B60 - cathepsin L2

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DISEASE

TITLE OF PUBLICATION

LINK TO PUBMED

Alopecia

Cell type-specific functions of the lysosomal protease cathepsin L in the heart.

17942402

Alopecia

Evaluation of the CTSL2 Gene as a Candidate Gene For Alopecia X in Pomeranians and Keeshonden.

17934903

Breast Neoplasms

Cathepsin L2, a novel human cysteine proteinase produced by breast and colorectal carcinomas.

9563472

Carcinoma, Renal Cell

Cathepsin L2, a novel human cysteine proteinase produced by breast and colorectal carcinomas.

9563472

Colorectal Neoplasms

Cathepsin L2, a novel human cysteine proteinase produced by breast and colorectal carcinomas.

9563472

Diabetes Mellitus, Type 1

Polymorphisms in the cathepsin L2 (CTSL2) gene show association with type 1 diabetes and early-onset myasthenia gravis.

17869649

Endometrial Neoplasms

Expression of cysteine protease cathepsin L is increased in endometrial cancer and correlates with expression of growth regulatory genes.

22452389

Infections

Fasciola hepatica serine protease inhibitor family (serpins): Purposely crafted for regulating host proteases.

32760059

Infections

Immune responses of cattle to experimental anti-Fasciola hepatica vaccines.

10425237

Myasthenia Gravis

Polymorphisms in the cathepsin L2 (CTSL2) gene show association with type 1 diabetes and early-onset myasthenia gravis.

17869649

Neoplasms

Cathepsin L2, a novel human cysteine proteinase produced by breast and colorectal carcinomas.

9563472

Neoplasms

Electrophoretic analysis of the cleaved form of serpin, squamous cell carcinoma antigen-1 in normal and malignant squamous epithelial tissues.

12874860

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