3.4.22.B60: cathepsin L2

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For detailed information about cathepsin L2, go to the full flat file.

Reaction

preference for Arg in the P1 position, Pro is accepted in the P2 position =

Synonyms

cathepsin L2, cathepsin L2 protease, CatL2, CL2, FhCatL2, FhCL2, FhpCL2

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.22 Cysteine endopeptidases

                3.4.22.B60 cathepsin L2

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Results	in table
1	Activating Compound
4	AA Sequence
2	Application
5	Cloned(Commentary)
40	Disease/ Diagnostics
2	Expression
6	General Information
8	Inhibitors
8	kcat/KM [mM/s]
4	Ki Value [mM]
33	KM Value [mM]
4	Localization
4	Molecular Weight [Da]
14	Natural Substrates/ Products (Substrates)
1	Organic Solvent Stability
155	Organism
1	pH Optimum
3	Posttranslational Modification
1	Protein Variants
6	Purification (Commentary)
1	Reaction
16	Reference
1	Renatured (Commentary)
10	Source Tissue
2	Specific Activity [micromol/min/mg]
48	Substrates and Products (Substrate)
4	Subunits
17	Synonyms
1	Temperature Optimum [°C]
33	Turnover Number [1/s]

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Application on EC 3.4.22.B60 - cathepsin L2

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APPLICATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

agriculture

Fasciola hepatica

-

screening of cathepsin L1/cathepsin L2 mimotopes and use of an M13 phage random 12-mers peptide library to evaluate their immunogenicity in sheep. Immunization of sheep with clones showing positive reactivity to rabbit cathepsin L1/L2 antiserum results in decrease in worm burdens after challenge. A significant reduction in worm size and burden is observed for those sheep immunized with clone 1. Animals receiving clone 20, show a significant reduction in egg output. Immunization induces a reduction of egg viability ranging from 58% to 82%. Vaccinated animals produce clone-specific antibodies which are boosted after challenge with metacercariae of Fasciola hepatica

700565

diagnostics

Fasciola hepatica

A0A220T1Z2

analysis of the diagnostic values of the three different clades of cathepsin Ls, FhCL1, FhCL2, and FhCL5, from adult flukes in an ELISA, test of sera from sheep and cattle naturally infected with Fasciola hepatica, assessment of cross-reactive antibodies, overview. For sheep sera, the sensitivity is 100% for the three rFhpCLs, while for cattle sera, the highest sensitivity is obtained using rFhpCL2 (97%), being equal for both rFhpCL1 and rFhpCL5 (87.9%), after adjusting cut-offs for maximum specificity

754983