3.4.22.B60: cathepsin L2

This is an abbreviated version, for detailed information about cathepsin L2, go to the full flat file.

Reaction

preference for Arg in the P1 position, Pro is accepted in the P2 position =

Synonyms

cathepsin L2, cathepsin L2 protease, CatL2, CL2, FhCatL2, FhCL2

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.B60 cathepsin L2

Turnover Number

Turnover Number on EC 3.4.22.B60 - cathepsin L2

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TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.06
benzoyl-Phe-Val-Arg-4-methylcoumarinyl-7-amide
Fasciola hepatica
P80342
pH 7.0, 37C, cathepsin L2
0.09
benzyloxycarbonyl-Arg-4-methylcoumarinyl-7-amide
Fasciola hepatica
P80342
pH 7.0, 37C, cathepsin L2
0.02
benzyloxycarbonyl-Arg-Arg-4-methylcoumarinyl-7-amide
Fasciola hepatica
P80342
pH 7.0, 37C, cathepsin L2
1.62
benzyloxycarbonyl-L-Leu-L-Arg-4-methylcoumarinyl-7-amide
Fasciola hepatica
-
FheCL2
1.7
benzyloxycarbonyl-L-Phe-L-Arg-4-methylcoumarinyl-7-amide
Fasciola hepatica
-
FheCL2
2.64
benzyloxycarbonyl-L-Pro-L-Arg-4-methylcoumarinyl-7-amide
Fasciola hepatica
-
FheCL2
1.6 - 3.2
benzyloxycarbonyl-Leu-Arg-7-amido-4-methylcoumarin
0.56
benzyloxycarbonyl-Phe-Arg-4-methylcoumarinyl-7-amide
Fasciola hepatica
P80342
pH 7.0, 37C, cathepsin L2
0.4 - 50
benzyloxycarbonyl-Phe-Arg-7-amido-4-methylcoumarin
1.9 - 2.6
benzyloxycarbonyl-Pro-Arg-7-amido-4-methylcoumarin
0.55
Boc-AGPR-7-amido-4-methylcoumarin
Fasciola hepatica
-
in 100 mM sodium phosphate buffer (pH 6.0) containing 1 mM dithiothreitol and 1 mM EDTA, at 37C
0.07
Boc-VLK-7-amido-4-methylcoumarin
Fasciola hepatica
-
in 100 mM sodium phosphate buffer (pH 6.0) containing 1 mM dithiothreitol and 1 mM EDTA, at 37C
0.23
Boc-VPR-7-amido-4-methylcoumarin
Fasciola hepatica
-
in 100 mM sodium phosphate buffer (pH 6.0) containing 1 mM dithiothreitol and 1 mM EDTA, at 37C
0.21
Leu-Val-Tyr-4-methylcoumarinyl-7-amide
Fasciola hepatica
P80342
pH 7.0, 37C, cathepsin L2
0.14
succinyl-Ala-Phe-Lys-4-methylcoumarinyl-7-amide
Fasciola hepatica
P80342
pH 7.0, 37C, cathepsin L2
0.08
succinyl-Leu-Leu-Val-Tyr-4-methylcoumarinyl-7-amide
Fasciola hepatica
P80342
pH 7.0, 37C, cathepsin L2
2.48
tert-butoxycarbonyl-Gly-Pro-Arg-4-methylcoumarinyl-7-amide
Fasciola hepatica
-
FheCL2
3.75
tert-butyloxycarbonyl-Val-Leu-Lys-4-methylcoumarinyl-7-amide
Fasciola hepatica
P80342
pH 7.0, 37C, cathepsin L2
1.19
tert-butyloxycarbonyl-Val-Pro-Arg-4-methylcoumarinyl-7-amide
Fasciola hepatica
P80342
pH 7.0, 37C, cathepsin L2
26.3
tosyl-Gly-Phe-Arg-7-amido-4-methylcoumarin
Fasciola hepatica
-
FhCatL2
1.17 - 1.93
tosyl-Gly-Pro-Arg-4-methylcoumarinyl-7-amide
440
tosyl-Gly-Pro-Arg-7-amido-4-methylcoumarin
Fasciola hepatica
-
FhCatL2
1.37
tosyl-Gly-Pro-Lys-4-methylcoumarinyl-7-amide
Fasciola hepatica
P80342
pH 7.0, 37C, cathepsin L2
0.18
tosyl-GPK-7-amido-4-methylcoumarin
Fasciola hepatica
-
in 100 mM sodium phosphate buffer (pH 6.0) containing 1 mM dithiothreitol and 1 mM EDTA, at 37C
0.26
tosyl-GPR-7-amido-4-methylcoumarin
Fasciola hepatica
-
in 100 mM sodium phosphate buffer (pH 6.0) containing 1 mM dithiothreitol and 1 mM EDTA, at 37C
0.95
Z-Leu-Arg-NHMe
Fasciola hepatica
-
in 100 mM sodium phosphate buffer (pH 6.0) containing 1 mM dithiothreitol and 1 mM EDTA, at 37C
0.09
Z-Phe-Arg-NHMe
Fasciola hepatica
-
in 100 mM sodium phosphate buffer (pH 6.0) containing 1 mM dithiothreitol and 1 mM EDTA, at 37C
0.014
Z-VVR-7-amido-4-methylcoumarin
Fasciola hepatica
-
in 100 mM sodium phosphate buffer (pH 6.0) containing 1 mM dithiothreitol and 1 mM EDTA, at 37C